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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | the expanding universe of γδT lytuphocytes : subsets, generation and function 显示文摘 | Serena M Nadia C L M Girliana G | 2008 | Current Immuno Rev2008，4，4： | 1 |
| 3 | Selenium content of Belgian cultivated soils and its uptake by field crops and vegetables显示文摘 | Ludwig De Temmerman Nadia Waegeneers Céline Thiry Gijs Du Laing Filip Tack Ann Ruttens | 2014 | Science of the Total Environment2014，，： | 1 |
| 4 | An integrated tool for microarray data clustering and cluster validity assessment显示文摘 | Nadia B Francisco A Padraig C | 2005 | Bioinformaties2005，21，： | 1 |
| 5 | lnterstitial lung diseases in children显示文摘 | Annick C Nadia N Ralph E | 2010 | Orphanet J Rare Dis2010，5，： | 1 |
| 6 | Lipoprotein profile in subclinical hypothyroidism:Response to levothyroxine replacement,a randomized placebo-controlled study 显示文摘 | Nadia C Ele F Fabio M | 2002 | J Clin Endocrinol Metab2002，87，4： | 1 |
| 7 | Stability of organic carbon in deep soil layers controlled by fresh carbon supply 显示文摘 | Fontaine S Barot S Barr6 P Nadia B Mary B Rumpel C | 2007 | Nature2007，450，7167： | 1 |
| 8 | Physiological and retinoid induced proliferations of epidermis basal keratinocytes are differently controlled显示文摘 | Beboit C Manuel M Nadia M | 2002 | EMBO J2002，21，13： | 1 |
| 9 | Perceptionof complex sounds in autism:Abnormal auditory cortical pro-cessing in children显示文摘 | Nathalie B M D Nadia C M D Pascal B P D et a1 | 2004 | Am J Psychiatry2004，161，： | 1 |
| 10 | The effect of the polymerization route on the amount of interphase in structured latex particles and their cor-responding films 显示文摘 | Didier C Nadia L | 2005 | Polymer2005，46，4： | 1 |
| 11 | Perception of complex sounds in autism: Abnormal auditory cortical processing in children显示文摘 | Nathalie B M D Nadia C M D Pascal B P D | 2004 | Am J Psychiatry2004，161，： | 1 |
| 12 | Preoperative Education in Cholecystectomy in the Context of a Multimodal Protocol of Perioperative Care: A Randomized, Controlled Trial显示文摘 | de Aguilar-Nascimento Jos 6 E Leal Fernando S Dantas Daniela C S Anabuki Nadia T de Souza Amanda M C Silva E Lima Ver6nica P Tanajura Guilherme H Canevari Mariana | 2013 | World journal of surgery2013，34，23： | 1 |
| 13 | Pressure effects on viscosity and flow stability of polyethylene melts during extrusion 显示文摘 | Enric S C Nadia E K Piau J M | 2006 | Rheol Acta2006，，45： | 1 |
| 14 | Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled 显示文摘 | Benoit C Manuel M Nadia M | 2002 | EMBO J2002，21，13： | 1 |
| 15 | Comparison of bleeding complications and one-year survival of low molecular weight heparin versus unfractioned heparin for acute myocardial infarction in elderly patients显示文摘 | Etienne P Nadia A Jean-Philippe C | 2013 | International Journal of Cardiology2013，166，1： | 1 |
| 16 | HeLicobacter pyLori viruLence factors and the host immune response: implications for therapeutic vaccination显示文摘 | Prinz C Nadia H VoLand P | 2003 | Trends MicrobioL2003，11，： | 1 |
| 17 | Supervised segmentation of the cervical cell images by using the genetic algorithms显示文摘 | Nadia L Latifa H Fairouz C | 2003 | Lecture Notes in Computer Science2003，2687，： | 1 |
| 18 | nd function of ATP-dependent potassium channels in late post-infarction remodeling 显示文摘 | Nadia I T Pierre P C Irene P Expression a | 2007 | J Mol Cell Cardiol2007，42，6： | 1 |
| 19 | Physiological and retin-oid-induced proliferations of epidermis basal keratinocytes are differently controlled 显示文摘 | Benoit C Manuel M Nadia M | 2002 | EMBO J2002，21，13： | 1 |
| 20 | Epigenetic programming by maternal behavior 显示文摘 | Ian C G Nadia C Frances A C | 2004 | Nat Neurosci2004，7，8： | 1 |
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