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| 1 | Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets显示文摘Although supplementing the diet with zinc oxide and arginine is known to improve growth in weanling piglets, the mechanism of action is not well understood. We measured the antioxidant status and inflammatory response in 48 weanling castrated male piglets fed diets supplemented with or without zinc oxide(2,500 mg Zn oxide per kg) and arginine(1%) starting at the age of 20 days. The animals were injected with lipopolysaccharide(100 μg/kg) on day 5. Half of them received another injection on day 12.Blood samples were taken just before and 6, 24 and 48 h after injection and the mucosa lining the ileum was recovered following euthanizing on days 7 and 14. Zinc supplementation increased reduced and total glutathione(GSH)(reduced and total) during days 5 to 7 and arginine decreased oxidized GSH measured on days 5 and 12 and the ratio of total antioxidant capacity to total oxidative status during days12 to 14. Zinc decreased plasma malondialdehyde measured on days 5 and 12 and serum haptoglobin measured on day 12 and increased both metallothionein-1 expression and total antioxidant capacity measured in the ileal mucosa on day 14. Tumour necrosis factor a concentration decreased from days 5 to12(all effects were significant at P < 0.05). This study shows that the zinc supplement reduced lipid oxidation and lipopolysaccharide-induced inflammation during the post-weaning period, while the arginine supplementation had only a limited effect. | Nadia Bergeron Claude Robert Frédéric Guay | 2017 | Animal Nutrition2017，，3： | 5 |
| 2 | HALOMETHYLATION OF POLYSTYRENE AND SUBSEQUENT PYRIDINATION VIA A HOMOLYTIC PATHWAY显示文摘Chloromethylation of polystyrene (PS) with two different chloromethylating systems methylal/thionyl chloride and paraformaldehyde/trimethylchlorosilane was studied. Soluble chloromethylated polystyrene with a degree of substitution of 89% was obtained. The Conant-Finkelstein reaction on the chloromethylated PS afforded soluble iodomethylated polystyrene with a degree of substitution as high as 96%. The reaction conditions of Minisci were employed to radically pyridinate PS via its iodomethylated derivative. Polyelectrolytes were formed which could be converted to normal polymers by treatment with a 20% aqueous solution of NaOH. | Sad Moulay Nadia Mehdi | 2006 | Chinese Journal of Polymer Science2006，24，6： | 3 |
| 3 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 4 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 5 | Laparoscopic left lateral hepatic lobectomy: a safer and faster technique显示文摘 | Giulio Belli Corrado Fantini Alberto D’Agostino Andrea Belli Luigi Cioffi Nadia Russolillo | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，2： | 1 |
| 6 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 7 | Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms显示文摘 | Ko JW Nadia S Thacker D | 1997 | Drug Metab Dispos1997，25，7： | 1 |
| 8 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 9 | Amyloid in bone marrow smears of patients affected by multiple myeloma显示文摘 | Fara Petruzziello Pio Zeppa Lucio Catalano Immacolata Cozzolino Giuseppe Gargiulo Pellegrino Musto Fiorella D’Auria Vincenzo Liso Rita Rizzi Nadia Caruso Catello Califano Eugenio Piro Maurizio Musso Vincenza Bonanno Antonietta Pia Falcone Salvatore Tafuto | 2010 | Annals of Hematology2010，，5： | 1 |
| 10 | Perceptionof complex sounds in autism:Abnormal auditory cortical pro-cessing in children显示文摘 | Nathalie B M D Nadia C M D Pascal B P D et a1 | 2004 | Am J Psychiatry2004，161，： | 1 |
| 11 | Perception of complex sounds in autism: Abnormal auditory cortical processing in children显示文摘 | Nathalie B M D Nadia C M D Pascal B P D | 2004 | Am J Psychiatry2004，161，： | 1 |
| 12 | The European Society of Breast Cancer Specialists recommendations for the management of young women with breast cancer显示文摘 | Fatima Cardoso Sibylle Loibl Olivia Pagani Alessandra Graziottin Pietro Panizza Laura Martincich Oreste Gentilini Fedro Peccatori Alain Fourquet Suzette Delaloge Lorenza Marotti Frédérique Penault-Llorca Anna Maria Kotti-Kitromilidou Alan Rodger Nadia Har | 2012 | European Journal of Cancer2012，，18： | 1 |
| 13 | Repurposing niclosamide for the treatment of neurological disorders显示文摘Neurological disorders are still one of the major causes of death,and the vast need to find efficacious therapy is nowadays an essential goal of the scientific community.For Parkinson's disease(PD),amyotrophic lateral sclerosis(ALS),spinal cord injury,and intracerebral hemorrhage. | Savina Apolloni Nadia D’Ambrosi | 2023 | Neural Regeneration Research2023，18，12： | 1 |
| 14 | Inhibition of photosystem Ⅱ photochemistry by Cr is caused by the alteration of both D1 protein and oxygen evolving complex显示文摘 | NADIA A A DEWEZ D DIDUR O | 2006 | Photosynthesis Research2006，89，： | 1 |
| 15 | Developmental outcomes of newborn enceohalopathy in the term infant显示文摘 | Nadia B John MK Glenys D | 2007 | Indian Journal of Pediatrics2007，68，6： | 1 |
| 16 | Spectrofluorometric properties of dissolved organic matter from central and southern Ontario streams and the influence of iron and irradiation显示文摘 | Lewis A M Peter J D | 2007 | Water Research2007，41，： | 1 |
| 17 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | 2007 (9555)2007，，9555： | 1 |
| 18 | Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer显示文摘 | Walter S Peter R Nadia D | 2006 | Virchows Arch2006，449，1： | 1 |
| 19 | Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children显示文摘 | Marco Sánchez-Guerra Nadia Pelallo-Martínez Fernando Díaz-Barriga Stephen J. Rothenberg Leticia Hernández-Cadena Sylvain Faugeron Luis F. Oropeza-Hernández Margarita Guaderrama-Díaz Betzabet Quintanilla-Vega | 2012 | Mut.Res.-Genetic Toxicology and Environmental Mutagenesis2012，，1： | 1 |
| 20 | MACS-annexin V cell sorting of semen samples with high TUNEL values decreases the concentration of cells with abnormal chromosomal content:a pilot study显示文摘We question whether,in men with an abnormal rate of sperm DNA fragmentation,the magnetic-activated cell sorting(MACS)could select spermatozoa with lower rates of DNA fragmentation as well as spermatozoa with unbalanced chromosome content.Cryopreserved spermatozoa from six males were separated into nonapoptotic and apoptotic populations.We determined the percentages of spermatozoa with(i)externalization of phosphatidylserine(EPS)by annexin V-Fluorescein isothiocyanate(FITC)labeling,(ii)DNA fragmentation by TdT-mediated-dUTP nick-end labeling(TUNEL),and(iii)numerical abnormalities for chromosomes X,Y,13,18,and 21 by fluorescence in situ hybridization(FISH),on the whole ejaculate and selected spermatozoa in the same patient.Compared to the nonapoptotic fraction,the apoptotic fraction statistically showed a higher number of spermatozoa with EPS,with DNA fragmentation,and with numerical chromosomal abnormalities.Compared to the whole ejaculate,we found a significant decrease in the percentage of spermatozoa with EPS and decrease tendencies of the DNA fragmentation rate and the sum of disomy levels in the nonapoptotic fraction.Conversely,we observed statistically significant higher rates of these three parameters in the apoptotic fraction.MACS may help to select spermatozoa with lower rates of DNA fragmentation and unbalanced chromosome content in men with abnormal rates of sperm DNA fragmentation. | Sahar El Fekih Nadia Gueganic Corinne Tous Habib Ben Ali Mounir Ajina Nathalie Douet-Guilbert Hortense Drapier Damien Beauvillard Frédéric Morel Aurore Perrin | 2022 | Asian Journal of Andrology2022，24，5： | 1 |
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