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| 1 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 2 | Cerebrovascular changes in chronic hypertension:Protective effects of enalapril in rats显示文摘 | Nag S Kilty D W | 1997 | Stroke1997，28，： | 1 |
| 3 | On the eddy characteristics of laminar axisymmetric flows through confined annular geometries with inward expansion显示文摘 | Nag D Datta A | 2007 | J Mechanical Engineering Science2007，221，2： | 1 |
| 4 | Plasmon-enhaneed low-intensity laser switching of gold : Vanadium dioxide nanoeomposites 显示文摘 | Ferrara D W MacQuarrie E R Nag J | 2011 | Applied Physics Letters2011，98，24： | 1 |
| 5 | The intersection of organizational identity,knowledge,and practice:Attempting strategic change via knowledge grafting显示文摘 | R NAG K G CORLEY D A GIOIA | | 0，，04： | 1 |
| 6 | Characteristics of the initial rising portion of near and far lightning return stroke electric field waveforms显示文摘 | Nag A Rakov V A Tsalikis D | 2012 | Atmospheric Research2012，117，12： | 1 |
| 7 | American Brachytherapy Society recommendations for transperineal permanent brachytherapy of prostate cancer显示文摘 | Nag S Beyer D Friedland J | 1999 | Int J Radiat Oncol Bios Phys1999，44，： | 1 |
| 8 | A Vacuolar Arsanite Transporter Necessary for ArsenicTolerance in the Arsenic Hyperaccumulating Fern Pteris vittata Is Missing in Flowering Plants显示文摘 | INDRIOLO E NAG N ELLIS D | 2010 | The Plant Cell2010，22，： | 1 |
| 9 | Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity显示文摘 | Banerjee D Rodriguez M Nag M | 2000 | Kidney Int2000，57，5： | 1 |
| 10 | Coumarin derived chromophores in the donor-acceptor-donor format that gives fluorescence enhancement and large two-photon activity in presence of specific metal ions显示文摘 | Ray D Nag A Jana A Goswami D Bharadwaj P K | 2010 | Inorganica Chimica Acta2010，363，12： | 1 |
| 11 | Negative adsorption of inorganic salts, sucrose and urea at solid-iiquid interfaces 显示文摘 | Nag A Sadhukhan B Chattoraj D K | 1987 | Colloids and Surfaces1987，23，12： | 1 |
| 12 | American Brachytherapy Society (ABS) recommendations for transperincal permanent brachytherapy of prostate cancer显示文摘 | Nag S Beyer D Friedland J | 1999 | Int J Radiat Oncol Biol Phys1999，44，4： | 1 |
| 13 | American Brachytherapy Society recommendations for transperineal permanent brachytherapy of pros- tate cancer显示文摘 | Nag S Beyer D Friedland J | 1999 | Int J Radiat Oncol Bios Phys1999，44，： | 1 |
| 14 | The intersection of organizational identity,knowledge,and practice:Attempting strategic change via knowledge grafting显示文摘 | Nag R K Corley K G Gioia D A | 2007 | Academy of Management Journal2007，50，4： | 1 |
| 15 | From common to uncommon knowledge: Foundations of firm-specific use of knowledge as a resource 显示文摘 | Nag R Gioia D A | 2012 | The Academy of Man- agement Journal2012，55，2： | 1 |
| 16 | Both CAG repeats and inverted DNA repeats stimulate spontaneous unequal sister-chromatid exchange in saccharomyces cerevisiae 显示文摘 | Suri M Stenson E K | 2004 | Nucleic Acids Res2004，32，18： | 1 |
| 17 | Review: molecular patho- genesis of blood brain barrier breakdown in acute brain injury 显示文摘 | Nag S Kapadia A Stewart D J | 2011 | Neuropathol Appl Neurobiol2011，37，1： | 1 |
| 18 | A randomized double-blind controlled study of nimedipine in acute cerebral i~hemic stroke显示文摘 | Nag D Garg RK Varma M | 1998 | Indian J Physiol Pharmacol1998，42，4： | 1 |
| 19 | Ocular surface disorder in pterygium; role of conjunctival impression cytology 显示文摘 | Bandyopadhyay R Nag D Mondal SK | 2010 | Indian J Pathol Mierobiol2010，53，4： | 1 |
| 20 | Regional landscape change as a consequence of plantation forestry expansion:an example in the Nelson region,New Zealand显示文摘 | Nag ashim a K Sands R W hyte A G D | 2002 | Forest Ecology and Management2002，163，： | 1 |
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