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| 1 | MicroRNA-6744-5p promotes anoikis in breast cancer and directly targets NAT1 enzyme显示文摘Objective:Anoikis is apoptosis that is induced when cells detach from the extracellular matrix and neighboring cells.As anoikis serves as a regulatory barrier,cancer cells often acquire resistance towards anoikis during tumorigenesis to become metastatic.MicroRNAs(miRNAs)are short strand RNA molecules that regulate genes post-transcriptionally by binding to mRNAs and reducing the expression of its target genes.This study aimed to elucidate the role of a novel miRNA,miR-6744-5 p,in regulating anoikis in breast cancer and identify its target gene.Methods:An anoikis resistant variant of the luminal A type breast cancer MCF-7 cell line(MCF-7-AR)was generated by selecting and amplifying surviving cells after repeated exposure to growth in suspension.Mi RNA microarray analysis identified a list of dysregulated miRNAs from which miR-6744-5 p was chosen for overexpression and knockdown studies in MCF-7.Additionally,the miRNA was also overexpressed in a triple-negative breast cancer cell line,MDA-MB-231,to evaluate its ability to impair the metastatic potential of breast cancer cells.Results:This study showed that overexpression and knockdown of miR-6744-5 p in MCF-7 increased and decreased anoikis sensitivity,respectively.Similarly,overexpression of miR-6744-5 p in MDA-MB-231 increased anoikis and also decreased tumor cell invasion in vitro and in vivo.Furthermore,NAT1 enzyme was identified and validated as the direct target of miR-6744-5 p.Conclusions:This study has proven the ability of miR-6744-5 p to increase anoikis sensitivity in both luminal A and triple negative breast cancer cell lines,highlighting its therapeutic potential in treating breast cancer. | Sharan Malagobadan Chai San Ho Noor Hasima Nagoor | 2020 | Cancer Biology & Medicine2020，17，1： | 2 |
| 2 | On regular fuzzy graphs显示文摘 | Nagoor Gani A Kadha K | 2008 | J Physical Sciences2008，12，： | 1 |
| 3 | Protective effects of N-acetyl cysteine on membrane-bound adeno- sine triphosphatases and minerals in isoproterenol-in- duced myocardial-infarcted rats :an in vivo and in vitro study 显示文摘 | Nagoor Meeran MF Stanely Mainzen Prince P | 2012 | J Biochem Mol Toxicol2012，26，7： | 1 |
| 4 | Regulation of Apoptotic Effects by Erythrocarpine E, a Cytotox- ic Limonoid from Chisocheton erythrocarpus in HSC -4 Human Oral Cancer Cells显示文摘 | Noor Hasima Nagoor Norliza Shah Jehan Muttiah Chong Soon Lim | 2011 | PLoS ONE2011，6，23： | 1 |
| 5 | Protective effects of N-aeetyl eysteine on lipid peroxide metabolism on isoproterenol-induced myocardial infracted rats 显示文摘 | Nagoor Meeran Stanely M F Mainzen Prince | 2011 | J Biochem Mol Toxicol2011，25，3： | 1 |
| 6 | Cloning,expression and protective capacity of 37 KDa outer membrane protein gene (ompH) of Pasteurella multocida serotype B: 2显示文摘 | Tan H Y Nagoor N H Sekaran S D | 2010 | TropicalBiomedicine2010，27，3： | 1 |
| 7 | Two stage fuzzy transportation problem显示文摘 | Nagoor A Abdul Razak K | 2006 | Journal of Physical Sciences2006，10，： | 1 |
| 8 | Cloning,expression and protective capacity of 37 kDa outer membrane protein gene (OmpH) of Pasteurella multocida serotype B:2显示文摘 | Tan H Y Nagoor N H Sekaran S D | | 0，，03： | 1 |
| 9 | The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment显示文摘 | Norahayu Othman Noor Hasima Nagoor Dong Wang | 2014 | BioMed Research International2014，，： | 1 |
| 10 | The role of microRNAs in the regula- tion of apoptosis in lung cancer and its application in cancer treat- ment显示文摘 | Othman N Nagoor NH | 2014 | Biomed Res Int2014，2014，31： | 1 |
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