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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 2 | Epigenetic pathways and glioblastoma treatment显示文摘 | Jennifer Clarke Clara Penas Chiara Pastori Ricardo J Komotar Amade Bregy Ashish H Shah Claes Wahlestedt Nagi G Ayad | 2013 | Epigenetics2013，，8： | 2 |
| 3 | Coping strategies and associated features of medically ill patients 显示文摘 | Feifel H Strack S Nagy VT | 1987 | Psychoso Med1987，49，6： | 1 |
| 4 | Elevated human epididymis protein 4 concentrations inchronic kidney disease显示文摘 | Béla Nagy Jr Krasznai ZT Balla H | 2012 | Ann Clin Biochem2012，49，4： | 1 |
| 5 | Coping strategies and associated features of medically ill patients显示文摘 | FEIFEL H STRACK S NAGY V T | 1987 | Psychosom Med1987，49，6： | 1 |
| 6 | Angiogenesis in pituitary adenomas and the normal pituitary gland显示文摘 | Turner H E Nagy Z Gatter K C | 2000 | J Clin Endocrinol Metab2000，85，3： | 1 |
| 7 | Are hepatomas a good target for suicide gene therapy ? An experimental study in rat using retroviral-mediated transfer of thymidine kinase gene 显示文摘 | Nagy H Panis Y Fabre M | 1998 | Surgery1998，123，1： | 1 |
| 8 | Effect of pitting corrosion on fatigue crack initiation and fatigue life显示文摘 | Rokhlin S I Kim J Y Nagy H | 1999 | Engineering Fracture Mechanics1999，62，4： | 1 |
| 9 | Are there any predictive factors for successful testicular sperm recovery in azoospermic patients 显示文摘 | Tournaye H Verheyen G Nagy P | 1997 | Hum Reprod1997，12，1： | 1 |
| 10 | Vascular permeability,vascular hyperpermeability and angiogenesis显示文摘 | NAGY JA BENJAMIN L ZENG H | 2008 | Angiogenesis2008，11，2： | 1 |
| 11 | Treatment of pituitary tumors显示文摘 | Gabriella Iván Nikoletta Szigeti-Csúcs Márk Oláh Cy?rgy M. Nagy Miklós I. Góth | 2005 | Endocrine2005，，1： | 1 |
| 12 | Effect of gamma- ray and microwave treatment on the shelf- life of beef-products stored at 5 :C显示文摘 | Nagy H A Suzan R M Bothaina M Y | 2002 | Food control2002，，13： | 1 |
| 13 | Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting显示文摘 | Nagy N Legendre H Engels O | 2003 | Cancer2003，97，8： | 1 |
| 14 | Effects of different hyaluronidase concentrations and mechanical procedures for cumulus cell removal on the outcome of intracytoplasmic sperm injection显示文摘 | Van H Nagy Z P Joris H | 1997 | Human Reproduction1997，12，10： | 1 |
| 15 | Relationship of sugar degradation to detrimental changes in citrus juice quality显示文摘 | Lee H S Nagy S | 1988 | Food Technol1988，42，： | 1 |
| 16 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 17 | Time-course of oocyte activation, pronucleus formation and cleavage in human oocytes fertilized by intracytoplasmic sperm injection 显示文摘 | NAGY ZP LIU J JORIS H | 1994 | Hum Reprod1994，9，9： | 1 |
| 18 | Coping strategies and associated features of medically ill patients 显示文摘 | FEFEIL H STRACK S NAGY V T | 1987 | Psychosom Med1987，49，： | 1 |
| 19 | Vascular permeability factor/ vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis显示文摘 | DVORAK H F NAGY J A FENG D | 1999 | Curr Top Microbiol Immunol1999，237，1： | 1 |
| 20 | Pisano synthesis and inhibitory activity of polyaspartic acid derivatives显示文摘 | Nagy H K Koves JM A | 1967 | Medical Chemistry1967，10，5： | 1 |
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