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| 1 | Anti-inflammatory pathways and alcoholic liver disease: Role of an adiponectin/interleukin-10/heme oxygenase-1 pathway显示文摘The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. Enhanced inflammation in the liver during ethanol exposure is an important contributor to injury. Kupffer cells, the resident macrophages in liver, are particularly critical to the onset of ethanol-induced liver injury. Chronic ethanol exposure sensitizes Kupffer cells to activation by lipopolysaccharide via Toll-like receptor 4. This sensitization enhances production of inflammatory mediators, such as tumor necrosis factor-α and reactive oxygen species, that contribute to hepatocyte dysfunction, necrosis, apoptosis, and fibrosis. Impaired resolution of the inflammatory process probably also contributes to ALD. The resolution of inflammation is an active, highly coordinated response that can potentially be manipulated via therapeutic interventions to treat chronic inflammatory diseases. Recent studies have identif ied an adiponectin/interleukin-10/heme oxygenase-1 (HO-1) pathway that is profoundly effective in dampening the enhanced activation of innate immune responses in primary cultures of Kupffer cells, as well as in an in vivo mouse model of chronic ethanol feeding. Importantly, induction of HO-1 also reduces ethanol-induced hepatocellular apoptosis in this in vivo model. Based on these data, we hypothesize that the development of therapeutic agents to regulate HO-1 and its downstream targets could be useful in enhancing the resolution of inflammation during ALD and preventing progression of early stages of liver injury. | Palash Mandal Michele T Pritchard Laura E Nagy | 2010 | World Journal of Gastroenterology2010，16，11： | 11 |
| 2 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 3 | Activation of the lipoxygen- ase pathway in the methionine enkephalin induced respiratory burst in human polymorphonuclear leukocytesl显示文摘 | Nagy J T Foris G Fulop T | 1988 | Life Sci1988，42，22： | 1 |
| 4 | Coping strategies and associated features of medically ill patients显示文摘 | FEIFEL H STRACK S NAGY V T | 1987 | Psychosom Med1987，49，6： | 1 |
| 5 | Construction and characterization of recombinant porcine adenovirus serotype 5 expressing the transmissiblegastroenteritis virus spike gene 显示文摘 | Tuboly T Nagy E | 2001 | J Gen Virol2001，82，1： | 1 |
| 6 | Construction and characterization of recombinant porcine adenovirus serotype 5 expressing the transmissible gastroenteritis virus spike gene显示文摘 | Tuboly T Nagy G | 2001 | Gen Virol2001，82，： | 1 |
| 7 | Initial clinical evaluation of an intraocular femtosecond laser in cataract surgery显示文摘 | Nagy Z Takacs A Fikorn T | 2009 | J Refract Surg2009，25，12： | 1 |
| 8 | Degeneration of the injured cervical cord is associated with remote changes in eorticospinal tract integrity and upper limb impairment显示文摘 | Patrick F Schneider T Nagy Z | 2012 | PLoS One2012，7，12： | 1 |
| 9 | Delineation of a carcinogenic Helicobacter pylori proteome 显示文摘 | Franco A T Friedman D B Nagy T A | 2009 | Mol Cell Proteomics2009，8，8： | 1 |
| 10 | Coping strategies and associated features of medically ill patients 显示文摘 | FEFEIL H STRACK S NAGY V T | 1987 | Psychosom Med1987，49，： | 1 |
| 11 | An atomic force microscopy study on the effect of bleaching agents on enamel surface显示文摘 | Hegedus C Bistey T Flora Nagy E | 1999 | J Dent1999，27，7： | 1 |
| 12 | Support and pretreatment effects on the hydrotreating activity of SBA - 15 and CMK - 5 supported nickel phosphide catalysts显示文摘 | Korenyi T I Vlt Z Nagy J B | 2008 | Catalysis Today2008，130，1： | 1 |
| 13 | Novel paradigms in vaccine development: from small pox eradication to therapeutic vaccines 显示文摘 | von Gabain A Nagy E Decker T | 2008 | Biol Chem2008，389，5： | 1 |
| 14 | Distribution of aluminum and boron in the periodical building units of boron-containing 13 zeolites 显示文摘 | Koraanyi T I Nagy J B | 2006 | J Phys Chem B2006，110，14： | 1 |
| 15 | Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus显示文摘 | Nagy G Koncz A Telarico T Fernandez D Ersek B Buzás E Perl A | | 0，，03： | 1 |
| 16 | Specific association of megalin and the Na ^+/H ^+ exchanger isofonn NHE3 in the proximal tubule显示文摘 | Biemesderfer D Nagy T DeGray B | 1999 | J Biol Chem1999，274，17： | 1 |
| 17 | Immunogenicity of the S protein of transmissible gastroenteritis virus expressed in baculovirus显示文摘 | Tuboly T Nagy E Dennis JR | 1994 | Arch Virol1994，137，12： | 1 |
| 18 | An atomic force microscopy study on the effect of bleaching agents on enamel surface 显示文摘 | HEGEDUS C BISTEY T FLORA - NAGY E | 1999 | Journal of Dentistey1999，27，： | 1 |
| 19 | A Mizuno-Todd-Ye type predictorcorrector algorithm for suffcient linear complementarity problems 显示文摘 | Illes T Nagy M | 2007 | European Journal of Operational Research2007，181，： | 1 |
| 20 | Single-shot TG FROG for the characterization of ultrashort DU~ pulses显示文摘 | Nagy T Simon P | 2009 | Opt Express2009，17，10： | 1 |
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