|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Molecular dynamics study on growth of carbon dioxide and methane hydrate from a seed crystal显示文摘In the current work,molecular dynamics simulation is employed to understand the intrinsic growth of carbon dioxide and methane hydrate starting from a seed crystal of methane and carbon dioxide respectively.This comparison was carried out because it has relevance to the recovery of methane gas from natural gas hydrate reservoirs by simultaneously sequestering a greenhouse gas like CO2.The seed crystal of carbon dioxide and methane hydrate was allowed to grow from a super-saturated mixture of carbon dioxide or methane molecules in water respectively.Two different concentrations(1:6 and 1:8.5)of CO2/CH4 molecules per water molecule were chosen based on gas–water composition in hydrate phase.The molecular level growth as a function of time was investigated by all atomistic molecular dynamics simulation under suitable temperature and pressure range which was well above the hydrate stability zone to ensure significantly faster growth kinetics.The concentration of CO2 molecules in water played a significant role in growth kinetics,and it was observed that maximizing the CO2 concentration in the aqueous phase may not result in faster growth of CO2 hydrate.On the contrary,methane hydrate growth was independent of methane molecule concentration in the aqueous phase.We have validated our results by performing experimental work on carbon dioxide hydrate where it was seen that under conditions appropriate for liquid CO2,the growth for carbon dioxide hydrate was very slow in the beginning. | Prajakta Nakate Bappa Ghosh Subhadip Das Sudip Roy Rajnish Kumar | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 2 |
| 3 | Carotid hemodynamic parameters as risk factors for cerebral infarction in Type 2 diabetic patients显示文摘 | Nakatou T Nakata K Nakamura A | 2004 | Diabetic Medicine2004，21，： | 1 |
| 4 | High-temperature operating characteristics of mixed-potentia-type NO2 sensor based on stabilized-zirconia tube and NiO sensing electrode显示文摘 | Norio Miura Wang Jian Mitsunobu Nakatou | 2006 | Sensors and Actuators B2006，114，2： | 1 |
| 5 | Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome显示文摘 | Nakat S Koike Y | 2007 | Hypertens Res2007，30，： | 1 |
| 6 | Evaluation of a new human immunodeficiency virus (HIV) antibody detection method based on time-resolved fluoroimmunoassay显示文摘 | Ushijima H Nakate H Kohno H | 1991 | Immunol Mehods1991，144，1： | 1 |
| 7 | NOx sensing char- acteristics of mixed-potential-type zirconia sensor using NiO sensing electrode at high temperatures显示文摘 | Miura N Wang J Nakatou M | 2005 | Electro- chemical and Solid-State Letters2005，8，2： | 1 |
| 8 | Drinking water Treatment by Using Uhrafihration Hollow Fiber Membranes 显示文摘 | Shuji Nakatsuka Ichiro Nakate Tadaaki Miyano | 1996 | Desalination1996，，106： | 1 |
| 9 | Clinical utility of thefunctional independence mea Sure for a SSe SSment of patient S with Alzheimer’s di Sea Se and va Scular dementia显示文摘 | Tanaka N Nakat Suka M IShii H | 2013 | PSychogeriatric S2013，13，4： | 1 |
| 10 | Drinking water treatment by using ultrafiltration hollow fiber membranes显示文摘 | Nakatsuka S J Nakate I Miyano T 1996 | 1996 | Desalination1996，106，： | 1 |
| 11 | Establishment of new preparation method for solid dispersion formulation of ta- crolinms显示文摘 | Yamashita K Nakate T Okimoto K | 2003 | Int J Pharm2003，267，12： | 1 |
| 12 | Comparison of detoxication activi- ty in midgut and fat body during fifth instar development of the to- bacco homworm, Manduca sexta 显示文摘 | Tare L G Nakat S S Hodgson E | 1982 | Comparative Biochemistry and Physiology PartC : Comparative Pharmacology1982，72，1： | 1 |
| 13 | Stellate Ganglion Block Modifies the Distribution of Lymphocyte Subset sand Natural-killer Cell Activity显示文摘 | Yokoyama M Masataka H Nakat suka Y | 2000 | Anesthesiology2000，92，1： | 1 |
| 14 | Drinking water treatment by using ultrafiltration hollow fiber membranes显示文摘 | SHUJI NAKATSUKA ICHIRO NAKATE | 1996 | Desalination1996，106，： | 1 |
| 15 | Drinking water treatment by using ultrafiltration hollow fiber membranes显示文摘 | Shuji Nakatsuka Ichiro Nakate Tadaaki Miyano | 1996 | Desalination1996，，106： | 1 |
| 16 | Drinking water treatment by using ultrafiltration hollow fiber membranes显示文摘 | Shuji Nakatsuka Ichiro Nakate and Tadaaki Miyano | 1996 | Desalination1996，106，13： | 1 |
| 17 | Establishment of new preparation method for solid dispersion formulation of tacrolimus 显示文摘 | Yamashita K Nakate T Okimoto K | 2003 | Int J Pharm2003，267，12： | 1 |
| 18 | Development of NOx Sensing Devices Based on YSZ and Oxide Electrode Aiming for Monitoring Car Exhausts显示文摘 | Norio M Nakatou M Serge Z | 2004 | J Ceram Int2004，，30： | 1 |
| 19 | Development of NOx sensing devices based on YSZ and oxide electrode aiming for monitoring car exhausts显示文摘 | Miura N Nakatou M Zhuiykov S | 2004 | Ceramics International2004，30，7： | 1 |
| 20 | Tumor vaccine thera- py against recrudescent tumor using dendritic cells simultaneously transfected with tumor RNA and granulocyte macro- phage colony stimulating factor RNA显示文摘 | NakaT Iwahashi M Nakamura M | 2008 | Cancer Sci2008，99，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员