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| 1 | Role of autophagy in the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system.Recently, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response that plays key roles in physiological processes, such as innate and adaptive immunity, adaptation to starvation, degradation of aberrant proteins or organelles, antimicrobial defense, and protein secretion. Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including IBD. Autophagy plays multiple roles in IBD pathogenesis by altering processes that include intracellular bacterial killing, antimicrobial peptide secretion by Paneth cells, goblet cell function, proinflammatory cytokine production by macrophages, antigen presentation by dendritic cells, and the endoplasmic reticulum stress response in enterocytes. Recent studies have identified susceptibility genes involved in autophagy, such as NOD2, ATG16L1, and IRGM, and active research is ongoing all over the world. The aim of this review is a systematic appraisal of the current literature to provide a better understanding of the role of autophagy in the pathogenesis of IBD. Understanding these mechanisms will bring about new strategies for the treatment and prevention of IBD. | Tomoya Iida Kei Onodera Hiroshi Nakase | 2017 | World Journal of Gastroenterology2017，23，11： | 27 |
| 2 | Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy显示文摘工具包受体酷氨酸激酶的组成的激活是在胃肠的基质肿瘤(大意) 的致病的一个关键因素。但是几乎没有 imatinib mesylate (IM ) 和外科疗法的联合是否能与 unresectable 在情况中延长幸存的很少信息多重肝转移。我们报导酷氨酸激酶禁止者 IM 和外科疗法对待的大意的手术后的复发的一个案例。对处理的起始的完全的反应(CR ) 为 18 瞬间继续,但是单个肝转移在 IM 处理期间在左肝的脑叶显示出生长。在再发性瘤的部分切除术以后,手术后的路线是平静的,没有复发,病人为 24 瞬间幸存。当前, imatinib 是为 non-resectable 大意的首要的治疗,但是单个代理人治疗经常导致肿瘤抵抗。就算到 imatinib 的忍耐发生, imatinib 和外科疗法的联合能在这里报导了的一些情况中延长幸存。然而,周期性的大意的很多案例上的进一步的研究是必要的评估治疗与外科相结合的 IM 的有效性。 | Chouhei Sakakura Akeo Hagiwara Koji Soga Koji Miyagawa Susumu Nakashima Tetsuji Yoshikawa Shuichi Kin Yuenn Nakase Nobuki Yamaoka Yoshihiko Sagara Hisakazu Yamagishi | 2006 | World Journal of Gastroenterology2006，12，17： | 5 |
| 3 | Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study显示文摘AIM To assess the relationship between serum levels of insulin-like growth factor-1(IGF1)/IGF-binding protein-3(IGFBP3)and the risk of esophageal carcinoma.METHODS We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective,nested case-control study of participants from the Japan Collaborative Cohort Study.A baseline survey was conducted from 1988 to 1990.Of the 110585 enrolled participants,35%donated blood samples.Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies.A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.RESULTS Thirty-one cases and 86 controls were eligible for the present assessment.The molar ratio of IGF1/IGFBP3,which represents the free and active form of IGF1,was not correlated with the risk of esophageal carcinoma.A higher molar difference between IGFBP3and IGF1,which estimates the free form of IGFBP3,was associated with a decreased risk of esophageal carcinoma(P=0.0146),and people in the highest tertile had the lowest risk(OR=0.107,95%CI:0.017-0.669).After adjustment for body mass index,tobacco use,and alcohol intake,the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma(P=0.0150).CONCLUSION The free form of IGFBP3,which is estimated by this molar difference,may be inversely associated with esophageal cancer incidence. | Yasushi Adachi Masanori Nojima Mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi | 2017 | World Journal of Gastroenterology2017，23，19： | 4 |
| 4 | Heparin bridge therapy and post-polypectomy bleeding显示文摘AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants. | Toshiyuki Kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura Masanori Nojima Hiroshi Nakase | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 5 | Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice显示文摘 | Kimura H Yoshikawa M Matsuda R Toriumi H Nishimura F Hirabayashi H Nakase H Kawaguchi S Ishizaka S Sakaki T | 2005 | Neurol Res2005，27，8： | 1 |
| 6 | Report of five cases显示文摘 | Sakaki T Morimoto T Nakase H Dural arteriovenous fistula of the posterior fossa developing after surgical occlusion of the sigmoid sinus | 1996 | J Neurofurg1996，84，1： | 1 |
| 7 | Mechanical stess-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs:an ex vivo study显示文摘 | Ariga K Yonerobu K Nakase T | 2003 | Spine2003，28，14： | 1 |
| 8 | Is elevation of the serum β-d-glucan level a paradoxical sign for trichosporon fungemia in patients with hematologic disorders? 显示文摘 | Nakase K Suzuki K Kyo T | 2012 | Int J Infect Dis2012，16，1： | 1 |
| 9 | Effects of anti-intercellular adhesion molecule-1 antibody on reperfusion injury included by late reperfusion in the rat middle cerebral artery occlusion model显示文摘 | Konemoto Y Nakase H Akita N | 2002 | Neurosurgery2002，51，4： | 1 |
| 10 | Chemical preconditioning with 3-nitropropionic acid in gerbil hippocampal slices: therapeutic window and the participation of adenosine receptor显示文摘 | AKETA S NAKASE H KAMADA Y | 2000 | Exp Neurol2000，166，： | 1 |
| 11 | Development of an oral drug delivery systemtargeting immune-regulating cells in experimentalinflammatory bowel disease: a new therapeutic strategy显示文摘 | Nakase H Okazaki K Tabata Y Uose S Ohana M Uchida K Matsushima Y Kawanami C Oshima C IkadaY Chiba T | 2000 | Journal of Pharmacology and ExperimentalTherapeutics2000，292，1： | 1 |
| 12 | Relationship between protective and antigen structure of Haemophilus parallinarum serotypes 1 and 2 显示文摘 | Kume K Sawata A Nakase Y | 1980 | American Journal of Vet erinary Research1980，41，1： | 1 |
| 13 | Heparin versus danaproid fo prevention of venous thromboembolism after hip surgery显示文摘 | Nakase J Toribatake Y Mouri Y | 2009 | J Orthop Surl (nongKong)2009，17，1： | 1 |
| 14 | Purification andcharacterization of new aldehyde reductases from Sporobolomycessalmonicolor AKU4429显示文摘 | KITA K NAKASE K YANASE H | 1999 | J Mol Catal B:Enzymatic1999，6，： | 1 |
| 15 | Localization of bone morphogenetic protein-2 in human osteoarthritis cartilage and osteophyte显示文摘 | Nakase T Miyaji T Tomita T | 2006 | Osteoarthritis Cartilage2006，11，： | 1 |
| 16 | Spinal cord blood flow and pathophysiological changes after transient spinal cord ischemia in cats显示文摘 | Morimoto T Nakase H | 1998 | Neurosurgery1998，42，： | 1 |
| 17 | Comparative study of 2,3,5-triphenyltetrazolium chloride( TTC )and hematoxylin-eosin staining for quantification of early brain ischemic injury in cats 显示文摘 | Okuno S Nakase H Sakaki T | 2001 | Neurol Res2001，23，6： | 1 |
| 18 | Catechins are not major components responsible for anti-genotoxic effects of tea extracts against nitroarenes显示文摘 | Takeshi Ohe Kumiko Marutani Shiho Nakase | 2001 | Mutation Research2001，496，： | 1 |
| 19 | Open label trial of clarithro-mycin therapy in japanese patients with crohns disease显示文摘 | Inoue S Nakase H Matsuura M | 2007 | J Gastro-enterol Hepatol2007，22，7： | 1 |
| 20 | Relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in Japan显示文摘 | Nakase K Nakaminami H Takenaka Y | 2014 | J Med Microbiol2014，63，5： | 1 |
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