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| 1 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 2 | Different natural courses of chronic hepatitis B with genotypes B and C after the fourth decade of life显示文摘AIM: To investigate the different impact of genotypes B and C on the development of liver cirrhosis (LC) among different age groups of patients with chronic hepatitis B (CH-B). METHODS: We examined the outcome of 121 patients with CH-B, divided by age and genotype. Univariate analyses were used to compare different groups. The Cox proportional hazard model was employed to evaluate factors affecting the development of LC. RESULTS: In patients < 30 years old, there were no significant predictors for development of LC. However, in patients ≥ 30 years old, genotype C was the only significant predictor. In the genotype C group, 8 of 12 patients who progressed to LC were 30-49 years old at initial diagnosis of chronic hepatitis (7 patients were positive for HBeAg). In the genotype B group, 4 of 8 patients who developed LC were ≥ 50 years old at initial diagnosis and were HBeAg-negative. CONCLUSION: The rate of development of LC was comparable in patients infected with genotypes B and C when CH-B occurred at < 30 years old. However, CH-B patients infected with genotype C showed poor prognosis if they were 30-49 years old and were positive for HBeAg. Age-specific natural course of CH-B should be considered when patients with CH-B are treated with antiviral drugs. | Tatsuji Maeshiro Shingo Arakaki Takako Watanabe Hajime Aoyama Joji Shiroma Tsuyoshi Yamashiro Tetsuo Hirata Akira Hokama Fukunori Kinjo Tomofumi Nakayoshi Tomokuni Nakayoshi Masashi Mizokami Jiro Fujita Hiroshi Sakugawa | 2007 | World Journal of Gastroenterology2007，13，34： | 7 |
| 3 | Magnifying Endoscopy Combined with Narrow Band Imaging System for Early Gastric Cancer: Correlation of Vascular Pattern with Histopathology (including video)显示文摘 | T. Nakayoshi H. Tajiri K. Matsuda M. Kaise M. Ikegami H. Sasaki | 2004 | Endoscopy2004，，12： | 2 |
| 4 | Magnifying endoscopy combined with narrow band im- aging system for early gastric cancern correlation of vascular pattern with histopathology(including video) 显示文摘 | NAKAYOSHI T TAJIRI H MATSUDA K | 2004 | Endoscopy2004，36，： | 1 |
| 5 | Early postoperative enteral nutrition is useful for recovering gastrointestinal motility and maintaining the nutritional status 显示文摘 | Kawasaki N Suzuki Y Nakayoshi T | 2009 | Surg Today2009，39，3： | 1 |
| 6 | Magnifyingendoscopy combined with narrow band imaging system forearly gastric cancer:correlation of vascular pattern withhistopathology(including video)显示文摘 | Nakayoshi T Tajiri H Matsuda K | 2004 | Endoscopy2004，36，12： | 1 |
| 7 | Magnifying endoscopy combined with narrow band imaging system for early gastric can- cer显示文摘 | Nakayoshi T Tajiri H Matsuda K | 2004 | Endscopy2004，36，12： | 1 |
| 8 | Difference in prognosis between patients infected with hepatitis B viras with genotype B and those with genotype C in the Okinawa Island:a prospective study显示文摘 | Nakayoshi J Maeshiro T Nakayoshi T | 2003 | Med Virol2003，70，3： | 1 |
| 9 | Early postoperativeenteral nutrition is useful for recovering gastrointestinal motility andmaintaining the nutritional status 显示文摘 | Kawasaki N Suzuki Y Nakayoshi T | 2009 | Surg Today2009，39，3： | 1 |
| 10 | Magnifying en- doscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video) 显示文摘 | Nakayoshi T Tajiri H Matsuda K | 2004 | Endoscopy2004，36，12： | 1 |
| 11 | Epidural analgesia and gastrointestinal motility after open abdominal surgery,a review显示文摘 | NAKAYOSHI T KAWASAKI N SUZUKI Y | 2008 | J Smooth Muscle Res2008，44，2： | 1 |
| 12 | Magnifying endoscopy combined with narrow band imaging system for early gastric cancer:correlation of vascular pattern with histopathology(including video)显示文摘 | Nakayoshi T Tajiri Hj Matsuda Kj | 2004 | Endoscopy2004，36，： | 1 |
| 13 | Magnifying endoscopycombined with narrow band imaging system for early gastric can-cer: correlation of vascular pattern with histopathology (includingvideo)显示文摘 | Nakayoshi T Tajirt H Matsuda K | 2004 | Endoscopy2004，36，12： | 1 |
| 14 | Early poatoperative enteral nurtrition is useful for recovering gasto-perative gastronintestional motility and maintaining the nutritional status 显示文摘 | Kawasaki N Suzuki Y Nakayoshi T | 2009 | Surg Today2009，39，3： | 1 |
| 15 | Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands:A prospective study显示文摘 | Nakayoshi T Maeshiro T Nakasone H | 2003 | J Med Viral2003，70，： | 1 |
| 16 | Magnifying endoscopy combined with narrow band imaging system for early gastric cancer:carrelation of vascular pattern with histopathology 显示文摘 | Nakayoshi T Tajiri H Matsuda K | 2004 | Endoscopy2004，36，： | 1 |
| 17 | Early postopera- tive enteral nutrition is useful for recovering gastrointesti- nal motility and maintaining the nutritional status显示文摘 | Kawasaki N Suzuki Y Nakayoshi T | 2009 | Surg Today2009，39，3： | 1 |
| 18 | Magnifying endoscopy combined with narrow band imaging system for early gastric cancer:correlation of vascular pattern with histopathology(including video)显示文摘 | Nakayoshi T Tajiri H Matsuda K | 2004 | Endoscopy2004，36，12： | 1 |
| 19 | Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology ( including video) 显示文摘 | Nakayoshi T Tajiri H Matsuda K | 2004 | Endoscopy2004，36，12： | 1 |
| 20 | High proportion of false positive reactions among donors with anti - HCV antibodies in a low prevalence area显示文摘 | Sakugawa H Nakasome H Nakayoshi T | 1995 | J Med Virol1995，46，4： | 1 |
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