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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 3 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 4 | 酮症倾向糖尿病综合征显示文摘众所周知糖尿病是由不同病因与发病机制引起的以糖脂代谢异常为主要表现的临床综合征,随着对其病因与发病机制的研究,对糖尿病的诊断分类在不断进行修订。现行分型基本是ADA于1997年提出,1999年为WHO糖尿病专家委员会确认。这次分型除保留妊娠糖尿病外基本按病因将以往病因明确的继发性糖尿病归为特殊型,而将大多数病因未明的临床糖尿病按其基本发病机制归为T1DM和了2DM。事实上仍有一些病无法明确诊断为T1DM或T2DM,因而近年来一直在探索这类糖尿病的发病机制、临床特点和分型的研究。下面这篇文献对此作了较全面的复习。本期摘译介绍给感兴趣的读者、作者参考。 | Balasubramanyam A Nalini R Hample CS 钱荣立 | 2009 | 中国糖尿病杂志2009，17，3： | 5 |
| 5 | Effect of dietary incorporation of n-3 polyunsaturated fatty acids rich oil sources on fatty acid profile, keeping quality and sensory attributes of broiler chicken meat显示文摘The present study was undertaken to investigate the effect of dietary replacement of commonly used vegetable oil(sunflower oil, SFO) with n-3 polyunsaturated fatty acids(PUFA) rich oil sources on broiler chicken performance, carcass yield, meat fatty acid composition, keeping quality and sensory attributes of meat. In the current experiment, 300 day-old Krishibro broiler chicks were randomly distributed to 5 dietary groups(50 replicates with 6 chicks in each) prepared by replacing SFO(2% and 3% of diet during starter and finisher periods, respectively) with n-3 PUFA rich soybean oil(SO), mustard oil(MO), linseed oil(LO) or fish oil(FO) on weight basis. Variation in oil sources had no influence(P > 0.05) on performance and carcass yield. Supplementation of MO, LO or FO significantly(P < 0.01) increased the n-3 PUFA, lowered the n-6 PUFA deposition and n-6:n-3 ratio in breast and thigh without affecting the organoleptic characters(appearance, flavour, juiciness, tenderness and overall acceptability) of meat.However, thiobarbituric acid reacting substances concentration in meat was increased(P < 0.01) with LO and FO supplementation compared with SFO. It is concluded that, dietary incorporation of MO, LO or FO at 2% and 3% levels during starter and finisher phase can enrich broiler chicken meat with n-3 PUFA without affecting the bird's performance and sensory characters of meat. | Sridhar Kalakuntla Nalini K.Nagireddy Arun K.Panda Narasimha Jatoth Raghunandan Thirunahari Ravinder R.Vangoor | 2017 | Animal Nutrition2017，，4： | 5 |
| 6 | Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan显示文摘The aim of this study was to improve the dissolution rate of the poorly soluble drug valsartan by delivering the drug as a liquisolid compact.Liquisolid compacts were prepared using propylene glycol as solvent,Avicel PH102 as carrier,and Aerosil 200 as the coating material.The crystallinity of the newly formulated drug and the interaction between excipients was examined by X-ray powder diffraction and Fourier-transform infrared spectroscopy,respectively.The dissolution studies for the liquisolid formula-tion and the marketed product were carried out at different pH values.The results showed no change in the crystallinity of the drug and no interaction between excipients.The dissolution efficiency of valsartan at 15 min was increased from 4.02% for plain drug and 13.58% for marketed product to 29.47% for the liquisolid formulation.The increase in the dissolution rate was also found to be significant compared to the marketed product at lower pH values,simulating the gastric environment where valsartan is largely absorbed.The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like valsartan. | Chella Naveen Nalini Shastri Rama Rao Tadikonda | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 4 |
| 7 | Diversification of primary gene pool through introgression of resistance to foliar diseases from synthetic amphidiploids to cultivated groundnut(Arachis hypogaea L.)显示文摘Groundnut(Arachis hypogaea L.)is widely grown and consumed around the world and is considered to have originated from a single hybridization event between two wild diploids.The utilization of wild germplasm in breeding programs has been restricted by reproductive barriers between wild and cultivated species and technical difficulties in making large numbers of crosses.Efforts to overcome these hurdles have resulted in the development of synthetic amphidiploids,namely ISATGR 278-18(Arachis duranesis×Arachis batizocoi)and ISATGR 5B(Arachis magna×A.batizocoi),which possess several desirable traits,including resistance to foliar diseases that generally cause huge yield losses annually in groundnut growing areas of Asia,America,and Africa.With an objective to improve foliar disease resistance,the primary gene pool was diversified by introgressing foliar disease resistance in five cultivated genotypes(ICGV 91114,ICGS 76,ICGV 91278,JL 24,and DH 86)from synthetic amphidiploids using a backcross breeding approach.Several introgression lines with resistance to two foliar diseases(rust and late leaf spot)were identified with levels of resistance equal to the donors.These backcross derived lines have shown a wide range of variation for several morphological and agronomic traits.These lines,after further evaluation and selection,can serve as donors in future breeding programs aimed atdeveloping improved cultivars with desirable agronomic traits,high resilience to biotic/abiotic stresses and a broadened genetic base. | Varsha Kumari M.V.C.Gowda Vinod Tasiwal Manish K.Pandey Ramesh S.Bhat Nalini Mallikarjuna Hari D.Upadhyaya Rajeev K.Varshney | 2014 | The Crop Journal2014，2，Z1： | 3 |
| 8 | Androgen insensitivity syndrome: do trinucleotide repeats in androgen receptor gene have any role?显示文摘瞄准:为了调查 CAG 和 GGN 的角色,作为在敏感症候群(AIS ) 影响雄激素的基因背景重复显型。方法:我们分析了一些 -CAG 和 GGN 在 69 个 AIS 案例中重复的雄激素受体(AR ) ,与 136 个无关的正常男个人一起。重复的长度用扩大由突变而产生之遗传的 genotyping 跟随了决定等位基因长度的聚合酶链反应(PCR ) 被分析。结果:我们揭示的学习更突然显著地在病人意味着一些 CAG 重复(平均数 18.25 重复,范围 14-26 重复) 与控制相比(平均数 22.57 重复,范围 12-39 重复)( 二尾巴的 P <
0.0001 ) 。然而, GGN 重复没在病人(平均数 21.48 重复) 和控制(平均数 21.21 重复) 之间显著地不同(二尾巴的 P = 0.474 ) 。在病人的组之中, CAG 的吝啬的数字在敏感情况(平均数 15.83 重复) 中在部分雄激素重复显著地不到在里面在敏感情况(平均数 19.46 重复) 中的完全的雄激素(二尾巴的 P <
0.0001 ) 。结论:调查结果建议在 AR 基因的重复的更短的长度可能充当低外显率在在敏感改变雄激素的表明的基因背景。 | Singh Rajender Nalini J. Gupta Baidyanath Chakravarty Lalji Singh Kumarasamy Thangaraj | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 9 | Prevention of post-ERCP pancreatitis: a comprehensive review显示文摘 | Martin L Freeman Nalini M Guda | 2004 | Gastrointestinal Endoscopy2004，，7： | 2 |
| 10 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 11 | Paddy Leaf Disease Detection Using an Optimized Deep Neural Network显示文摘Precision Agriculture is a concept of farm management which makes use of IoT and networking concepts to improve the crop.Plant diseases are one of the underlying causes in the decrease in the number of quantity and quality of the farming crops.Recognition of diseases from the plant images is an active research topic which makes use of machine learning(ML)approaches.A novel deep neural network(DNN)classification model is proposed for the identification of paddy leaf disease using plant image data.Classification errors were minimized by optimizing weights and biases in the DNN model using a crow search algorithm(CSA)during both the standard pre-training and fine-tuning processes.This DNN-CSA architecture enables the use of simplistic statistical learning techniques with a decreased computational workload,ensuring high classification accuracy.Paddy leaf images were first preprocessed,and the areas indicative of disease were initially extracted using a k-means clustering method.Thresholding was then applied to eliminate regions not indicative of disease.Next,a set of features were extracted from the previously isolated diseased regions.Finally,the classification accuracy and efficiency of the proposed DNN-CSA model were verified experimentally and shown to be superior to a support vector machine with multiple cross-fold validations. | Shankaranarayanan Nalini Nagappan Krishnaraj Thangaiyan Jayasankar Kalimuthu Vinothkumar Antony Sagai Francis Britto Kamalraj Subramaniam Chokkaligam Bharatiraja | 2021 | Computers, Materials & Continua2021，，7： | 2 |
| 12 | Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors显示文摘 | Wan Zhihong Zhi Ning Wong Susan Keyvanfar Keyvan Liu Delong Raghavachari Nalini Munson Peter J Su Su Malide Daniela Kajigaya Sachiko Young Neal S | 2010 | Journal of Clinical Investigation2010，，10： | 2 |
| 13 | Effect of heavy metals CO^2+ , Ni^2+ and Cd^2+ on growth and metabolism of eabbage显示文摘 | NALINI P CHANDRA P S | 2002 | Plant Science2002，163，： | 1 |
| 14 | Exogenous leptin improves insulin sensitivity in ethanol fed insulin resistant mice显示文摘 | Balasubramaniyan V Nalini N | 2006 | Clin Chim Acta2006，367，12： | 1 |
| 15 | Marchiafava-Bignami disease:Two cases with magnetic resonance imaging and positron e- mission tomography scan findings 显示文摘 | NALINI A KOVOOR J M DAWN R | 2009 | Neurol India2009，57，5： | 1 |
| 16 | OsPRP3, a flower specific proline-rich protein of rice, determines extracellular matrix structure of floral organs and its overexpression confers cold-tolerance显示文摘 | Gothandam K M Nalini E Karthikeyan S | 2010 | Plant Molecular Biology2010，72，： | 1 |
| 17 | Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells显示文摘 | Nalinie S W Tissa T M Susan M D | 2009 | Nucleic Acids Res2009，37，8： | 1 |
| 18 | New drug delivery systems of captopril显示文摘 | Rajinder S M Nalini M S | 1992 | Drug Dev Ind Pharm1992，18，14： | 1 |
| 19 | Chemopreventive ef- fect of trans-resveratrol-a phytoalexin against colonic aber- rant crypt loci and cell proliferation in 1,2-dimethylhy- drazine induced colon carcinogenesis 显示文摘 | Sengottuvelan M Viswanathan P Nalini N | 2006 | Carcinogenesis2006，27，5： | 1 |
| 20 | Sympathetic skin response in monomelic amyotrophy显示文摘 | GOURIE-DEVI M NALINI A | | 0，，03： | 1 |
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