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| 1 | Benefits of early postoperative jejunal feeding in patients undergoing duodenohemipancreatectomy显示文摘瞄准:学习早手术后的肠内的营养是否减少复杂并发症的发生或改进营养的地位追随者 duodenohemipancreatectomy (DHP ) 。方法:我们学习了为一个 peri-ampullary 团经历了 DHP 的 39 个病人。23 个病人收到了全部的父母营养然后开始有在手术后的白天(邮政部门) 之间的营养的口头的吸入 7 和 14 [晚手术后的肠内的营养(LPEN ) 组] 。十六个病人开始有肠内的在手术以后整个空肠造口术导管日子喂[早手术后的肠内的营养(EPEN ) 组] 。在早手术后的阶段的复杂并发症和实验室数据的发生在在 LPEN 和 EPEN 组之间的比较被学习。结果:在 EPEN 组的白朊和全部的蛋白质的浆液层次比在 LPEN 组的那些显著地高。身体团索引的损失显著地作为与 LPEN 组相比在 EPEN 组被压制。在操作比在 LPEN 组在 EPEN 组更快显著地被恢复以后,淋巴细胞计数立即减少了。EPEN 组显著地比 LPEN 组显示出手术后的胰腺的管,以及住院的显著地更短的长度的更少发生。在在二个组之间的另外的手术后的复杂并发症的发生没有有效差量,例如推迟的胃的倒空,外科的地点感染,胆管炎,和小肠阻塞。结论:EPEN 是为为一个 peri-ampullary 团经历了 DHP 的病人的一个安全、有益的机会。 | Takehiro Okabayashi Michiya Kobayashi Isao Nishimori Tekeki Sugimoto Toyokazu Akimori Tsutomu Namikawa Ken Okamoto Saburo Onishi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，1： | 23 |
| 2 | Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients显示文摘瞄准:由于源于先进胃的癌症的腹膜炎 carcinomatosa 与腹水在病人在它的静脉内的管理以后在血浆和腹水检验 paclitaxel 集中。方法:有腹水的二个病人在这研究由于源于胃的癌症的腹膜炎 carcinomatosa 被包括。在血浆和腹水的 paclitaxel 集中为 72 h 被调查以防 1 和 168 h 以防 2 在静脉内的管理以后。结果:在血浆的 paclitaxel 集中在管理以后立即达到顶点,在 24 h 以内在 0.1 微摩尔(85 ng/mL ) 的阀值价值下面由快速的减少列在后面。相反,在腹水的 paclitaxel 集中在管理以后为 24 h 逐渐地增加了到与在血浆发现的水平一致的水平。在 24 h 以后,在腹水和血浆的 paclitaxel 的水平变得类似,与被维持直到 72 h 追随者管理的最佳的水平。结论:在腹水的 paclitaxel 的集中在静脉内的管理以后为多达 72 h 为癌症房间的治疗在最佳的水平以内被维持。Paclitaxel 是为胃的癌症的恶意的腹水的治疗的有希望的药。 | Michiya Kobayashi Junichi Sakamoto Tsutomu Namikawa Ken Okamoto Takehiro Okabayashi Kengo Ichikawa Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，9： | 14 |
| 3 | Laparoscopic endoscopic cooperative surgery as a minimally invasive treatment for gastric submucosal tumor显示文摘Laparoscopic wedge resection is a useful procedure fortreating patients with submucosal tumor(SMT) including gastrointestinal stromal tumor(GIST) of the stomach. However, resection of intragastric-type SMTs can be problematic due to the difficulty in accurately judging the location of endoluminal tumor growth, and often excessive amounts of healthy mucosa are removed; thus, full-thickness local excision using laparoscopic and endoscopic cooperative surgery(LECS) is a promising procedure for these cases. Our experience with LECS has confirmed this procedure to be a safe, feasible, and minimally invasive treatment method for gastric GISTs less than 5 cm in diameter, with outcomes similar to conventional laparoscopic wedge resection. The important advantage of LECS is the reduction in the resected area of the gastric wall compared to that in conventional laparoscopic wedge resection using a linear stapler. Early gastric cancer fits the criteria for endoscopic resection; however, if performing endoscopic submucosal dissection is difficult, the LECS procedure might be a good alternative. In the future, LECS is also likely to be indicated for duodenal tumors, as well as gastric tumors. Furthermore, developments in endoscopic and laparoscopic technology have generated various modified LECS techniques, leading to even less invasive surgery. | Tsutomu Namikawa Kazuhiro Hanazaki | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，14： | 7 |
| 4 | Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer显示文摘5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically accumulates in cancer cells owing to the impaired metabolism of ALA to Pp IX in mitochondria, which results in a red fluorescence following irradiation with blue light and the formation of singlet oxygen. Fluorescence navigation by photodynamic diagnosis(PDD) using ALA provides good visualization and detection of gastric cancer lesions and is a potentially valuable diagnostic tool for gastric cancer for evaluating both the surgical resection margins and extension of the lesion. Furthermore, PDD using ALA might be used to detect peritoneal metastases during preoperative staging laparoscopy, where it could provide useful information for the selection of a therapeutic approach. Another promising application for this modality is in the evaluation of lymph node metastases. Photodynamic therapy(PDT) using ALA to cause selective damage based on the accumulation of a photosensitizer in malignant tissue is expected to be a non-invasive endoscopic treatment for superficial early gastric cancer. ALA has the potential to be used not only as a diagnostic agent but also as a therapeutic drug, resulting in a new strategy for cancer diagnosis and therapy. Here, we review the current use of PDD and PDT in gastric cancer and evaluate its future potential beyond conventional modalities combined with a light energy upconverter, a light-emitting diode and nearinfrared rays as light sources. | Tsutomu Namikawa Tomoaki Yatabe Keiji Inoue Taro Shuin Kazuhiro Hanazaki | 2015 | World Journal of Gastroenterology2015，21，29： | 6 |
| 5 | Clinicopathological features of early gastric cancer with duodenal invasion显示文摘The incidence of early gastric cancer(EGC) with duodenal invasion is extremely low,although advanced gastric cancer that arises in the antrum occasionally invades the duodenum.We investigated the clinicopathological features of EGC with duodenal invasion and provided strategies for clinical management.A Medline search was performed using the keyword 'early gastric cancer' and 'duodenal invasion'.Additional articles were obtained from references within the papers identif ied by the Medline search.We revealed that EGC with duodenal invasion was of the superf icial spreading type of tumor.Tumors > 60 mm in size invaded the duodenum more extensively,and the distance of duodenal invasion from the pyloric ring was further in the elevated type than in the depressed type of tumor.There was no signif icant difference between the length of duodenal invasion and the histological type of the tumor.Gastric cancer located adjacent to the pyloric ring,even if cancer invasion was conf ined to the mucosa or submucosa,was more likely to invade the duodenum.The present study reveals that the elevated type of EGC is associated with more extensive duodenal invasion when the tumor size is > 60 mm,thus highlighting the importance of identif ication of duodenal invasion in these cases.We also reveal that suff icient duodenal resection with a cancer-free distal surgical margin should be performed in cases of duodenal invasion. | Tsutomu Namikawa Kazuhiro Hanazaki | 2009 | World Journal of Gastroenterology2009，15，19： | 4 |
| 6 | Laparoscopic splenectomy for splenic hamartoma:Case management and clinical consequences显示文摘Splenic hamartoma is a rare benign tumor,and although minimally invasive surgery may be suitable for this condition,there have only been 2 previous reports of laparoscopic surgery.Here we report the third case of splenic hamartoma managed by laparoscopic splenectomy.A 37-year-old male was incidentally diagnosed by abdominal ultrasonography with a hypoechoic mass measuring 2.5 cm × 2.4 cm in the spleen.Color Doppler sonography showed multiple flow signals within the mass and contrast-enhanced computed tomography revealed strong enhancement of the lesion.On T1-and T2-weighted magnetic resonance images,the splenic mass was demonstrated as isointense and hyperintense respectively.Although a malignant tumor could not be ruled out,a hand-assisted laparoscopic splenectomy was performed because the splenic mass was limited in size and had not invaded adjacent organs.The pathological diagnosis was splenic hamartoma.The postoperative course was uneventful and the patient was discharged by the seventh postoperative day.Although splenic hamartomas have some specific imaging features,more reports and analyses of these cases are required to increase the reliability of the diagnosis and management.Hand-assisted laparoscopic splenectomy may play a pivotal role in the postoperative diagnosis and management of this condition. | Tsutomu Namikawa Hiroyuki Kitagawa Jun Iwabu Michiya Kobayashi Manabu Matsumoto Kazuhiro Hanazaki | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 4 |
| 7 | Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis显示文摘 | Chikako Namikawa Zhang Shu-Ping John Raynor Vyselaar Yasuko Nozaki Yoshihisa Nemoto Masafumi Ono Naoaki Akisawa Toshiji Saibara Makoto Hiroi Hideaki Enzan Saburo Onishi | 2004 | Journal of Hepatology2004，，5： | 3 |
| 8 | Clinical analysis of primary anaplastic carcinoma of the small intestine显示文摘Primary anaplastic carcinoma is a rare variant of small intestinal cancer. Most reports of primary anaplastic carcinoma of the small intestine are isolated case reports, therefore the clinicopathological features, therapeutic management, and surgical outcome of this tumor type remain unclear. This review analyzes the available clinical characteristics of primary anaplastic carcinoma of the small intestine and investigates key differences from differentiated adenocarcinoma of the small intestine. A Medline search was performed using | Tsutomu Namikawa Kazuhiro Hanazaki | 2009 | World Journal of Gastroenterology2009，15，5： | 3 |
| 9 | Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study显示文摘 | Kengo Ichikawa Takehiro Okabayashi Hiromichi Maeda Tsutomu Namikawa Tatsuo Iiyama Takeki Sugimoto Michiya Kobayashi Toshiki Mimura Kazuhiro Hanazaki | 2013 | Surgery Today2013，，7： | 2 |
| 10 | Mucin phenotype of gastric cancer and clinicopathology of gastric-type differentiated adenocarcinoma显示文摘Differentiated adenocarcinoma of the stomach is classified into gastric or intestinal phenotypes based on mucus expression. Recent advances in mucin histochemistry and immunohistochemistry have highlighted the importance of such a distinction, and it is important clinically to distinguish between gastricand intestinal-type differentiated adenocarcinoma. However, a clinical and pathological diagnosis of this type is often difficult in early gastric cancer because of histological similarities between a hyperplastic epithelium and lowgrade atypia. Furthermore, determining tumor margins is often difficult, even with extensive preoperative examination. It is therefore critical to consider these diagnostic difficulties and different biological behaviors with high malignant potential when treating patients with gastric-type differentiated adenocarcinoma. | Tsutomu Namikawa Kazuhiro Hanazaki | 2010 | World Journal of Gastroenterology2010，16，37： | 2 |
| 11 | Clinicopathological study of cardiac tamponade due to pericardial metastasis originating from gastric cancer显示文摘AIM: To review the cases reported in the literature,examined their clinicopathological features, and evaluated the efficacy of different therapeutic modalities for this rare condition.METHODS: A search of the MEDLINE database revealed 16 cases of pericarditis carcinomatosa (PC)originating from GC reported in the literature between1982 and 2005. Additional detailed data were obtained from the authors of these studies for subsequent clinicopathological investigation. We have also described about a case study from our own clinic.RESULTS: The mean age of cases with pericarditis carcinomatosa originating from GC was 54 years.Females were diagnosed at a younger age (46.3 years)compared to males (58 years). The mean survival period after diagnosis was 4.5 mo. No statistical differences in the length of survival time were found between different therapeutic modalities, such as drainage, and local and/or systemic chemotherapy after drainage. However,three cases who underwent systemic chemotherapy survived for more than 10 mo. Cases that developed metachronous cardiac tamponade for more than 2years after the diagnosis of GC generally survived for a longer period of time, although this was not statistically significant. Multivariate analysis revealed that low levels of carcinoembryonic antigen (CEA), and CEA and/or cancer antigen 19-9 (CA 19-9) were associated with longer survival.CONCLUSION: Cases with low levels of CEA, and CEA and/or CA 19-9 should undergo systemic chemotherapy with or without local chemotherapy after drainage. | Michiya Kobayashi Takehiro Okabayashi Ken Okamoto Tsutomu Namikawa Keijiro Araki | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 12 | Impact of jejunal pouch interposition reconstruction after proximal gastrectomy for early gastric cancer on quality of life: short- and long-term consequences显示文摘 | Tsutomu Namikawa Toyokazu Oki Hiroyuki Kitagawa Takehiro Okabayashi Michiya Kobayashi Kazuhiro Hanazaki | 2012 | The American Journal of Surgery2012，，2： | 2 |
| 13 | Magnetic Properties and Workability of 6.5% Si Steel Sheet Manufactured by Siliconizing Process显示文摘siliconning process to manufacture 6.5% Si steel sheet has been developed. Electric components, such as transformers and reactors are made easily from 6.5% Si steel sheet. However, improved workability is desirable to increase the applications. Therefore the improvement of workability of 6.5% Si steel sheet was investigated, and the results were obtained as followst: (a) workability of 6.5% Si steel sheet is deteriorated by grain boundary oxidization. (b) grain boundary oxidization can be restrained by the addition of C. Workability and magnetic properties of 6.5% Si steel sheet with C addition are discussed. Furthermore, it was found that the workability of high Si steel sheet was improved remarkably by varging the Si content gradient along the thickness without deterioration of high frequency magnetic properties. This newly developed magnetic gradient high Si steel sheet is also discussed. | Koichiro Fujita, Misao Namikawa and Yoshikazu Takada (Materials and Processing Research Center NKK Corp., 1-1 Minamiwatarida-cho, Kawasaki-ku Kawasaki-shi, 210-0855 Japan) | 2000 | Journal of Materials Science & Technology2000，16，2： | 2 |
| 14 | 显示文摘 | OishiU N Namikawa T Yamazaki Y | 2000 | Surface and Coatings Technology2000，132，： | 1 |
| 15 | Lapa- roscopic lymph node dissection around the inferior mesenteric artery for cancer in the lower sigmoid colon and rectum:is 193 lymph node dissection with preservation of the left colic artery feasible 显示文摘 | KOBAYASH I M OKAMOTO K NAMIKAWA T | 2006 | Surg Endosc2006，，20： | 1 |
| 16 | 显示文摘 | Munakata M Namikawa M Motogama M | 2002 | Trans Magn Soc Japan2002，2，5： | 1 |
| 17 | The SCID-hu mouse;murine model for the analysis of human hematolymphoid differentiation and function显示文摘 | Tchemia JA Namikawa R Kaneshima H | 2000 | Clin Orthop2000，24，7： | 1 |
| 18 | 显示文摘 | Namikawa Y Fujiwara S Kotani T | 2001 | Journal of Crystal Growth2001，229，14： | 1 |
| 19 | Gingival overgrowth in a dog that received long-term cyclosporine for immune-mediated hemolytic anemia显示文摘 | Namikawa K Maruo T Honda M Hirata H Lynch J Madarame H | 2012 | Can Vet J2012，53，： | 1 |
| 20 | Development of watermelon harvesting gripper显示文摘 | Iida M Furube K Namikawa K | 1996 | Japan Soc Agric Mach1996，58，3： | 1 |
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