|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Improving medication adherence in chronic cardiovascu- lar disease显示文摘 | Nancy MA | 2008 | Critical Care nurse2008，28，5： | 1 |
| 3 | Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry 显示文摘 | Mihai G William TA Nancy MA | 2007 | Eur Heart J2007，28，8： | 1 |
| 4 | Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo显示文摘 | Shinya N Ma LJ | 2000 | Kidney Int2000，58，： | 1 |
| 5 | Lmproving medication adherence in chroniccardioves- cular disease 显示文摘 | Nancy MA | 2008 | Criticnl Care Nurse2008，28，5： | 1 |
| 6 | Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure:An analysis from the OPTIMIZE-HF registry显示文摘 | Mihai G William TA Nancy MA | 2007 | Eur Heart J2007，28，： | 1 |
| 7 | Improving evidence-based care for heart failure in outpatient cardiology practices:primary results of the registry to improve the use of evidencebased heart failure therapies in the outpatient setting显示文摘 | Gregg CF Nancy MA Anne B | 2010 | Circulation2010，122，： | 1 |
| 8 | Lmproving medication adherence in chronic car- diovescular disease 显示文摘 | Nancy MA | 2008 | Critical Care Nurse2008，28，5： | 1 |
| 9 | Nurses' Uniform Color and Feelings/Emotions in School-Aged Children Receiving Health Care显示文摘 | Nancy MA Jane B James FB | | 0，，02： | 1 |
| 10 | Improving medication adherence in chronic cardiovas-cu- lar disease显示文摘 | Nancy MA | 2008 | Critical Care nurse2008，28，5： | 1 |
| 11 | Improving medication adherence in chronic cardiovascular disease显示文摘 | Nancy MA | 2008 | Critical Care nurse2008，28，5： | 1 |
| 12 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2显示文摘Dear Editor,Sphingosine 1-phosphate(S1P)plays crucial roles in various physiological processes,including immune response,vascular development,and neural system homeostasis1 through activating S1P receptors(S1PRs).Notably,a desirable concentration gradient of S1P which is achieved by S1P transporters,including spinster homolog 2 protein(SPNS2)and MFSD2B that transport S1P from the intracellular side to the extracellular side of cells,2,3 is essential for proper S1P signaling.SPNS2 and MFSD2B belong to the major facilitator superfamily(MFS),and specifically. | Yaning Duan Nancy C.P.Leong Jing Zhao Yu Zhang Dat T.Nguyen Hoa T.T.Ha Na Wang Ruixue Xia Zhenmei Xu Zhengxiong Ma Yu Qian Han Yin Xinyan Zhu Anqi Zhang Changyou Guo Yu Xia Long N.Nguyen Yuanzheng He | 2024 | Cell Research2024，34，2： | 0 |
| 13 | Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products显示文摘Characterization of filamentous fungal regulatory elements remains challenging because of time-consuming transformation technologies and limited quantitative methods.Here we established a method for quantitative assessment of filamentous fungal promoters based on flow cytometry detection of the superfolder green fluorescent protein at single-cell resolution.Using this quantitative method,we acquired a library of 93 native promoter elements from Aspergillus nidulans in a high-throughput format.The strengths of identified promoters covered a 37-fold range by flow cytometry.P_(zipA) and P_(sltA)were identified as the strongest promoters,which were 2.9-and 1.5-fold higher than that of the commonly used constitutive promoter P_(gpdA).Thus,we applied P_(zipA)and P_(sltA)to activate the silent nonribosomal peptide synthetase gene Afpes1 from Aspergillus fumigatus in its native host and the heterologous host A.nidulans.The metabolic products of Afpes1 were identified as new cyclic tetrapeptide derivatives,namely,fumiganins A and B.Our method provides an innovative strategy for natural product discovery in fungi. | Peng-Lin Wei Jie Fan Jingwen Yu Zihui Ma Xian Guo Nancy PKeller Erwei Li Chunbo Lou Wen-Bing Yin | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 14 | Annual sea level variations off Atlantic Canada from satellite altimetry显示文摘Annual cycle of sea level off Atlantic Canada has been investigated based on a merged satellite altimetry dataset and a monthly temperature and salinity dataset.The altimetric results were compared with coastal tide-gauge data and steric height calculated from the temperature and salinity dataset.There was a general north-south variation in the amplitude of the altimetric annual cycle,increasing from 4 cm in the Labrador Sea to 15 cm in the Gulf Stream and the North Atlantic Current Region.The annual cycle in the deep ocean can approximately be accounted for by the steric height variability relative to 700 m,in which the thermosteric effect was the dominant contributor.The halosteric effect over the continental slope,especially over the northern Labrador Slope was also important.While the thermosteric effect occurred dominantly at the top 100 m water column,there was substantial halosteric variation in the 100–300 m water column.The annual sea level cycle along the Canadian Atlantic coast showed a complicated pattern in amplitude,but the phase was highly coherent with the highest sea level in fall.The steric height accounts for a substantial portion of the coastal annual cycle,but other factors such as wind forcing may be equally important. | Guoqi Han Nancy Chen Zhimin Ma | 2016 | Satellite Oceanography and Meteorology2016，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员