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| 1 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 2 | Adverse life events among community-dwelling persons ased 65-70 years: gender differences in occurrence and perceived peyeholosical conse- quences显示文摘 | Seematter-Bagnoud L Karmanioh A Santos-Ef nann B | 2010 | Soc Psychiatry Psychiar Epidemiol2010，45，1： | 1 |
| 3 | Nobel metal abundances in Komatiite suites from Alexo, Ontario and Gorgona Island, Colombia显示文摘 | Briigmann G E Arndt N T Hofi'nann A W | 1987 | Geochimica et Cosmochimica Acta1987，51，： | 1 |
| 4 | Fiber-optic sensors for concrete strain/stress measurement显示文摘 | Nann A Yang C C Pan K | 1991 | ACI materials Journal1991，88，3： | 1 |
| 5 | A new' ag- ing male symptoms' rating scale 显示文摘 | Heinemann LAJ Zimme~nann T Vermeulen A | 1999 | AgingMale1999，2，： | 1 |
| 6 | General practitioners and depression-first use of the Depression Attitude Questionnaire显示文摘 | Botega NJ Nann A Blizard R | 1992 | International Journal of Methods in Psychiatric Research1992，2，： | 1 |
| 7 | Chromium treatment has no effect in patients with poorly controlled, insulin treated type 2 diabetes in an obese western population显示文摘 | NANNE K SEBASTIAAN T H FRANK G A | 2006 | Diabetes Care2006，29，3： | 1 |
| 8 | High Quality ZnS Shells for CdSe Nanoparticles:Rapid Microwave Synthesis显示文摘 | ZIEGLER J MERKULOV A NANN T | 2007 | Langrnuir2007，23，14： | 1 |
| 9 | The ecology of Ebola virus 显示文摘 | Groseth A Fel&nann H Strong J E | 2007 | Trends Microbiol2007，15，9： | 1 |
| 10 | How I treat my inflammatory bowel disease-patients with thiopurines?显示文摘Thiopurines are essential drugs to maintain remission in patients with inflammatory bowel disease(IBD).Thiopurines used in IBD are azathioprine(2.0-2.5 mg/kg),mercaptopurine(1.0-1.5 mg/kg) and thioguanine(0.2-0.3 mg/kg).However,mainly due to numerous adverse events associated with thiopurine use,almost 50% of the patients have to discontinue conventional thiopurine treatment.Extensive monitoring and the application of several treatment strategies,such as split-dose administration,co-administration with allopurinol or dose reduction/increase,may increase the chance of successful therapy.With this review,we provide practical information on how thiopurines are initiated and maintained in two thiopurine research centers in The Netherlands.We provide clinical information concerning safety issues,indications and management of therapy that may serve as a guide for the administration of thiopurines in IBD patients in daily practice. | Berrie Meijer Chris JJ Mulder Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 0 |
| 11 | Diarrhoea in a patient with metastatic melanoma:Ipilimumab ileocolitis treated with infliximab显示文摘Administration of ipilimumab,a cytotoxic T-lymphocyte associated antigen-4-blocking monoclonal antibody,leads to enhancement of the anti-tumor T-cell respons and as a result shows a significant survival benefit in metastatic melanoma patients.Therefore patients are currently receiving this promising therapy as a secondline strategy.Unfortunately,by activation of the T-cell immune reponse,ipilimumab therapy may lead to an unwanted induction of different autoimmune phenomena.Diarrhoea and colitis occur in up to one third of patients.Here we present a case of ipilimumab induced ileocolitis which was successfully treated with infliximab,an anti-tumor necrosis factor monoclonal antibody,after corticosteroid therapy failure.Although formal trials are lacking,recently publicated series suggest that infusional therapy of infliximab is effective in ipilimumab induced ileocolitis. | Rob ME Slangen Alfonsus JM van den Eertwegh Adriaan A van Bodegraven Nanne KH de Boer | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3： | 0 |
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