| 2 | Anti-C4d chimeric antigen receptor regulatory T cells suppressed allograft rejection in ABO-incompatible heart transplantation显示文摘ABO blood group-incompatible(ABOi)transplantation has been developed to overcome the serious problem of donor organ shortage.However,antibody-mediated rejection(ABMR)remains as the main limitation to successful ABOi transplantation.Introduction of desensitization treatment improved the outcomes of ABOi transplantation by suppressing ABMR;however,this strong,nonspecific immunosuppression also increases infectious complications.Recently,chimeric antigen receptor regulatory T cells(CAR Tregs)were developed to improve the antigen specificity,viability,and suppressive activity of Tregs.C4d deposition is a marker of ABMR and is also found in most ABOi allograft tissues.Based on these findings,we developed anti-C4d CAR Tregs to suppress ABMR in ABOi allografts. | Sun-Kyung Lee Jerome Han Honglin Piao Nara Shin Joon Young Jang Ji-Jing Yan Hyori Kim Junho Chung Jaeseok Yang | 2022 | Genes & Diseases2022，9，1： | 0 |
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