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| 1 | Recent advances in non-invasive magnetic resonance imaging assessment of hepatocellular carcinoma显示文摘Magnetic resonance(MR) imaging of the liver is an important tool for the detection and characterization of focal liver lesions and for assessment of diffuse liver disease,having several intrinsic characteristics,represented by high soft tissue contrast,avoidance of ionizing radiation or iodinated contrast media,and more recently,by application of several functional imaging techniques(i.e.,diffusion-weighted sequences,hepatobiliary contrast agents,perfusion imaging,magnetic resonance(MR)-elastography,and radiomics analysis). MR functional imaging techniques are extensively used both in routine practice and in the field of clinical and pre-clinical research because,through a qualitative rather than quantitative approach,they can offer valuable information about tumor tissue and tissue architecture,cellular biomarkers related to the hepatocellular functions,or tissue vascularization profiles related to tumor and tissue biology. This kind of approach offers in vivo physiological parameters,capable of evaluating physiological and pathological modifications of tissues,by the analysis of quantitative data that could be used in tumor detection,characterization,treatmentselection,and follow-up,in addition to those obtained from standard morphological imaging. In this review we provide an overview of recent advanced techniques in MR for the diagnosis and staging of hepatocellular carcinoma,and their role in the assessment of response treatment evaluation. | Davide Ippolito Riccardo Inchingolo Luigi Grazioli Silvia Girolama Drago Michele Nardella Marco Gatti Riccardo Faletti | 2018 | World Journal of Gastroenterology2018，24，23： | 13 |
| 2 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 3 | Gadoxetic acid magnetic-enhanced resonance imaging in the diagnosis of cholangiocarcinoma显示文摘The use of liver magnetic resonance imaging is increasing thanks to itsmultiparametric sequences that allow a better tissue characterization, and the useof hepatobiliary contrast agents. This review aims to evaluate gadoxetic acidenhanced magnetic resonance imaging in the diagnosis and staging ofcholangiocarcinoma and its different clinical and radiological classificationsproposed in the literature. We also analyze the epidemiology, risk factors incorrelation with clinical findings and laboratory data. | Riccardo Inchingolo Cesare Maino Marco Gatti Eleonora Tricarico Michele Nardella Luigi Grazioli SandroSironi Davide Ippolito Riccardo Faletti | 2020 | World Journal of Gastroenterology2020，26，29： | 4 |
| 4 | Yield Response to Deficit Irrigation and Partial Root-Zone Drying in Processing Tomato (Lycopersicon esculentum Mill,)显示文摘 | Eugenio Nardella Marcella Michela Giuliani Giuseppe Gatta Antonio De Caro | 2012 | Journal of Agricultural Science and Technology(A)2012，2，2： | 3 |
| 5 | Screening tests of disseminated intravascular coagulation: guidelines for rapid and specific laboratory diagnosis 显示文摘 | Yu M Nardella A Pechet L | 2000 | Crit Care Med2000，2，6： | 1 |
| 6 | MRI and CT in the evaluation of congenital heart diseases 显示文摘 | Secchi F Giardino A Nardella VG | 2010 | Pediatr Med Chit2010，32，6： | 1 |
| 7 | Endovascular treatment of inlracranial arterio-venous malformations with Onyx embolizarion: preliminary experience显示文摘 | Florio F Lauriola W Nardella M | 2003 | Radiol Med (Torino)2003，106，56： | 1 |
| 8 | Anticoagulant low molecular weight fucans produced by radiacal process and ion exchange chromatography of high molecular weight fucans extracted from the brown seaweed Ascophyllum nodosum 显示文摘 | Nardella A Chaubet F Boissson-Vidal C | 2007 | Carbohydr Res2007，289，： | 1 |
| 9 | Use of the valsalva graft and long-term follow-up显示文摘 | De Paulis R Scaffa R Nardella S | 2010 | J Thorac Cardiovasc Surg2010，140，6： | 1 |
| 10 | Reduction of allogeneic red blood cell usage during cardiacsurgery by an integrated intra-and postoperative bloodsalvage strategy: results of a randomized comparison 显示文摘 | WELTERT L NARDELLA S RONDINELLI M B | 2013 | Transfusion2013，53，4： | 1 |
| 11 | Pharmacokinetics and bioavailability of aerosolized tobramycin in cystic fibrosis显示文摘 | Geller DE Pitlick WH Nardella PA | 2002 | Chest2002，122，1： | 1 |
| 12 | 查看详情显示文摘 | Doghieri F Nardella A Sarti G L | | 0，，： | 1 |
| 13 | Use of the Valsalva graft and long-term follow-up显示文摘 | Ruggero De Paulis Raffaele Scaffa Saverio Nardella Daniele Maselli Luca Weltert Fabio Bertoldo Davide Pacini Fabrizio Settepani Giuseppe Tarelli Roberto Gallotti Roberto Di Bartolomeo Luigi Chiariello | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，6： | 1 |
| 14 | Anticoagulant low molecular weight fucans produced by radical process and ion exchange chromatography of high molecular weight fucans extracted from the brown seaweed Ascophyllum nodosum 显示文摘 | Nardella A Chaubet F Boisson V C | 1996 | Carbohydr Res1996，289，： | 1 |
| 15 | Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of nyc 显示文摘 | LEONI B D NATOLI M NARDELLA M | 2012 | Differentiation2012，83，3： | 1 |
| 16 | Screening tests of disseminated intravasoular coagulation guidelines for rapid and specific laboratory diagsosis显示文摘 | Yu M Nardella A Pechet L | 2000 | Crit Care Med2000，28，： | 1 |
| 17 | Anticoagulant low molecular weight fucans produced by radical process and ion exchange chromatography of high molecular weight fucans extracted from the brown seaweed As Cophyllum nodosum 显示文摘 | Nardella A Chaubet F Vidal CB Blondin C Durand P Jozefonvicz J | 1996 | Carbohydr Res1996，289，： | 1 |
| 18 | Endovascular treatment of intracranial arterio-venous malformations with Onyx embolization:preliminary experience显示文摘 | FLORIO F LAURIOLA W NARDELLA M | 2003 | Radiol Med2003，106，5： | 1 |
| 19 | Consumer willingness to pay for pesticide-free fresh fruit and vegetables in Italy显示文摘 | Boccaletti S Nardella M | 2000 | Interna- tional Food and Agribusiness Management Review2000，3，： | 1 |
| 20 | Differential expression of S6K2 dictates tissue-specific requirement for S6KI in mediating aberrant mTORCI signaling and tumorigenesis显示文摘 | Nardella C Lunardi A Fedele G | 2011 | Cancer Res2011，71，10： | 1 |
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