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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Effect of Helicobacter pylori infection and its eradication on cell proliferation,DNA status,and oncogene expression in patients with chronic gastritis显示文摘 | Nardone G Staibano S Rocco A | 1999 | Gut1999，44，6： | 1 |
| 3 | Subdural hematoma in a pa- tient with spontaneous intracranial hypotension and cerebral venous thrombosis显示文摘 | Nardone R Caleri F Golaszewski S | 2010 | Neurol Sci2010，31，5： | 1 |
| 4 | Fundamental properties and performance of conventional bearings-only target motion analysis显示文摘 | Nardone S C Lindgren A Gong K | 1984 | IEEE Trans on Automatic Control1984，29，9： | 1 |
| 5 | Amplification of padlock probes for DNA diagnostics by cascade rolling circle amplification or the polymerase chain reaction 显示文摘 | THOMAS D C NARDONE G A RANDALL S K | 1999 | Archives of Pathology & Laboratory Medicine1999，123，12： | 1 |
| 6 | Observability criteria for bearing-only target motion analysis显示文摘 | NARDONE S C AIDALA V J | 1981 | IEEE Taransaction on Aerospace and Electronic System1981，17，2： | 1 |
| 7 | Observability Criteria for Bearing- sonly Target Motion Analysis 显示文摘 | Nardone S C Aidala V J | 1981 | IEEE Transactions on Aerospace and Electronic Systems1981，17，2： | 1 |
| 8 | Observability Criteria for Bearings-Only Target Motion Analysis 显示文摘 | NARDONE S C AIDALA V J | 1981 | IEEE Transactions on Aerospace and Electronic Systems1981，17，2： | 1 |
| 9 | Biased estimation properties of the pseudolinear tracking filter 显示文摘 | AIDALA V J NARDONE S C | 1982 | IEEE Transactions on Aerospace and Electronic Systems(S0018-9251)1982，18，4： | 1 |
| 10 | Observabillty criteria for bearings-only target motion analysis 显示文摘 | NARDONE S C AIDALA V J | 1981 | IEEE Transactions on Aerospace and Electronic Systems1981，17，2： | 1 |
| 11 | Observability criteria for bearings-only target motion analysis 显示文摘 | NARDONE S C MDALA V J | 1981 | IEEE Trans on Aerospace and Electronic Systems1981，17，3： | 1 |
| 12 | A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT 显示文摘 | Gwack Y Sharma S Nardone J | 2006 | Nature2006，441，7093： | 1 |
| 13 | Cytometric and biochem- ical characterization of human breast cancer cells reveals heteroge- neous myoepithelial phenotypes 显示文摘 | Leccia F Nardone A Corvigno S | 2012 | Cytometry A2012，81，11： | 1 |
| 14 | Amplification of padlock probes for DNA diagnostics by cascade rolling circle amplification or thepolymerase chain reaction显示文摘 | Thomas D Nardone G Randall S | 1999 | Arch Pathol Lab Med1999，123，： | 1 |
| 15 | Biased estimation properties of the pseudolinear tracking filter显示文摘 | A idala V J Nardone S C | 1982 | IEEE Trans on AES1982，18，4： | 1 |
| 16 | Fundamental Properties and Performance of Conventional Bearings-only Target Motion Analysis 显示文摘 | Nardone S C Lindgren A G Gong K F | 1984 | IEEE Trans on Automatic Control1984，29，9： | 1 |
| 17 | Fundamental properties and performance of conventional bearings-only target motion analysis 显示文摘 | Nardone S C Lingren A G | 1984 | IEEE Transactions on Automatic Control1984，29，9： | 1 |
| 18 | Assessment of the safety of long- term bazedoxifene treatment on the reproductive tract in postmenopausal women with osteoporosis: results of a 7-year, randomized, placebo-controlled, phase 3 study显示文摘 | Palacios S de Villiers TJ Nardone Fde C | 2013 | Maturitas2013，76，1： | 1 |
| 19 | In-situ-reinforced titanium matrix composites显示文摘 | M S Thompson V C Nardone | 1991 | Material Science and Engineering A1991，144，12： | 1 |
| 20 | Observability criteria for bearing-only target motion analysis 显示文摘 | Nardone S C Aidala V J | 1981 | IEEE Trans on AES1981，17，2： | 1 |
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