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| 1 | Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury显示文摘Spinal cord injury(SCI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no U.S.Food and Drug Administration-approved cure.Enolase,a multifunctional glycolytic enzyme upregulated after SCI,promotes pro-and anti-inflammatory events and regulates functional recovery in SCI.Enolase is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway activation.SCI-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in SCI.Enolase surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated kinase.Studies here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following SCI.Also,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase activity.The combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following SCI.The role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neurodegenerative diseases.Hence,this review discusses the importance of enolase activation and inhibition as a potential therapeutic target following SCI to promote neuronal survival and regeneration. | Hannah MMcCoy Rachel Polcyn Naren LBanik Azizul Haque | 2023 | Neural Regeneration Research2023，18，7： | 3 |
| 2 | Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury显示文摘Spinal Cord Injury(SCI)is a debilitating condition characterized by damage to the spinal cord,resulting in loss of function,mobility,and sensation.Although increasingly prevalent in the US,no FDA-approved therapy exists due to the unfortunate complexity of the condition,and the difficulties of SCI may be furthered by the development of SCI-related complications,such as osteoporosis.SCI demonstrates two crucial stages for consideration:the primary stage and the secondary stage.While the primary stage is suggested to be immediate and irreversible,the secondary stage is proposed as a promising window of opportunity for therapeutic intervention.Enolase,a metabolic enzyme upregulated after SCI,performs non-glycolytic functions,promoting inflammatory events via extracellular degradative actions and increased production of inflammatory cytokines and chemokines.Neuron-specific enolase(NSE)serves as a biomarker of functional damage to neurons following SCI,and the inhibition of NSE has been demonstrated to reduce signs of secondary injury of SCI and to ameliorate dysfunction.This Viewpoint article involves enolase activation in the regulation of RANK-RANKL pathway and summarizes succinctly the mechanisms influencing osteoclast-mediated resorption of bone in SCI.Our laboratory proposes that inhibition of enolase activation may reduce SCI-induced inflammatory response and decrease osteoclast activity,limiting the chances of skeletal tissue loss in SCI. | RAMSHA SHAMS NAREN LBANIK AZIZUL HAQUE | 2021 | BIOCELL2021，45，6： | 3 |
| 3 | Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury显示文摘Spinal cord injuries affect nearly five to ten individuals per million every year. Spinal cord injury causes damage to the nerves, muscles, and the tissue surrounding the spinal cord. Depending on the severity, spinal injuries are linked to degeneration of axons and myelin, resulting in neuronal impairment and skeletal muscle weakness and atrophy. The protection of neurons and promotion of myelin regeneration during spinal cord injury is important for recovery of function following spinal cord injury. Current treatments have little to no effect on spinal cord injury and neurogenic muscle loss. Clemastine, an Food and Drug Administration-approved antihistamine drug, reduces inflammation, protects cells, promotes remyelination, and preserves myelin integrity. Recent clinical evidence suggests that clemastine can decrease the loss of axons after spinal cord injury, stimulating the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes that are capable of myelination. While clemastine can aid not only in the remyelination and preservation of myelin sheath integrity, it also protects neurons. However, its role in neurogenic muscle loss remains unclear. This review discusses the pathophysiology of spinal cord injury, and the role of clemastine in the protection of neurons, myelin, and axons as well as attenuation of skeletal muscle loss following spinal cord injury. | Ali Myatich Azizul Haque Christopher Sole Naren L.Banik | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 4 | Salmonella typhimurium strain SL7207 induces apoptosis and inhibits the growth of HepG2 hepatoma cells in vitro and in vivo显示文摘Salmonella typhimurium is probably most extensively studied tumor-targeting bacteria and SL7207 is one of its attenuated strains.SL7207 was first made for bacterial vaccine development and its therapeutic efficacy and safety for hepatoellular carcinoma has not been characterized.In this study,the inhibitory ability of SL 7207-lux on human hepatoma HepG2 cells was tested in vitro and in vivo.A bacterial luminescent gene cluster(lux CDA BE)was transfected into SL7207 to better monitor the invasion of the bacteria.The results show that SL7207-lux can rapidly enter HepG2 cells and localize in the cytoplasm.This invasion represses ell proliferation and induces apoptosis.In vivo real-time invasion studies showed that the bacteria gradually accumulate in the tumor.This enrichment was confirmed by anatomic observation at 5 days after inoculation.About 40%of tumor growth was inhibited by SL7207-lxx at 34 days post-treatment without significant loss of body weight.The area of necrosis of tumor tissue was clearly increased in the treated group.Bacterial quantification showed that the number of colony-forming units per gram of bacteria within tumor tissue was approximately 1000-fold higher than that of liver and spleen.These data suggest that attenuated S.typhimurium strain SL7207 has potential for the treatment of cancers. | Baowei Li Hongwei He Shenghua Zhang Wuli Zhao Naren Li Rongguang Shao | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 2 |
| 5 | Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes显示文摘 | ArabindaDas Naren L.Banik Swapan K.Ray | 2010 | Cancer2010，，1： | 2 |
| 6 | Characterization of CFTR expression and chloride channel activity in human endothelia显示文摘 | Tousson A Van Tina BA Naren AP | 1998 | Am J Physiol Cell Physiol1998，275，： | 1 |
| 7 | MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes显示文摘 | Sellers ZM Naren AP Xiang Y | | 0，，： | 1 |
| 8 | Evaluating EMMS model for simulating high solid flux risers显示文摘 | Naren P R Lali A M Ranade V V | | 0，，8： | 1 |
| 9 | Metamemory :a theoretical framework and new findings显示文摘 | Nelson T D Narens L | 1990 | The psychology of Learning and Motivation1990，26，： | 1 |
| 10 | Nonlinear Optical Properties of Water-Soluble Polymeric Dyes with Biological Applications 显示文摘 | Varnavski O Ispasoiu R G Narenal M | 2000 | Macromolecules2000，，33： | 1 |
| 11 | Calpain in the pathophysiology of spinal cord injury:neuroprotection with Calpain inhibitors显示文摘 | Ray SK Hogan EL Naren L | 2003 | Brain Research Reviews2003，42，： | 1 |
| 12 | Laryngopharyngeal Reflux Disease in Children显示文摘 | Naren Venkatesan Harold Pine Michael Underbrink | 2013 | The Pediatric Clinics of North America2013，，： | 1 |
| 13 | Two New Quaternary Selenostannates Synthesized Under Solvothermal Conditions:Crystal Structure and Reflectance Spectra of(1,4-dab H)2Mn Sn Se4and(1,4-dab H2)Cu2Sn Se4显示文摘 | Baiyin M H Naren J Gang G | 2013 | Inorganic Chemistry Communications2013，35，： | 1 |
| 14 | B cell- surface density of complement restriction factors (CD46, CD55, and CD59) : o- ral squamous cell carcinoma versus other solid tumors 显示文摘 | Naren MH Shuler Charles DDS | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol & Endodontics2007，103，2： | 1 |
| 15 | MULTIGRID TECHNIQUE APPLIED TO LINEAR TIME-DEPENDENT HYPERBOLIC SYSTEMS显示文摘A system of linear time-dependent hyperbolic partial differential equations in the form of the time-domain Maxwell′s equations is numerically solved using ageometric multigrid method.The multilevel method is an adaptation of Ni′s cell-vertex based multigrid technique,originally proposed for accelerating steady state convergence of nonlinear time-dependent Euler equations of gas dynamics.We discuss issues pertaining to the application of the geometric multigrid method to a system of equations where the major issue is of accurately propagating linear waves over large distances leading to major constraints on the required grid resolution in terms of points-perwavelength. | Naren Deore Avijit Chatterjee | 2013 | Transactions of Nanjing University of Aeronautics and Astronautics2013，30，3： | 1 |
| 16 | Accuracy of feeling-of-knowing judgments for predicting perceptual identification and relearning显示文摘 | Nelson TO Gerler D Narens L | 1984 | J Exp Psychol Gen1984，113，2： | 1 |
| 17 | Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves显示文摘 | Amy E. Munnelly Leonard Cochrane Joshua Leong Naren R. Vyavahare | 2011 | Biomaterials2011，，1： | 1 |
| 18 | Metamemory: A theoretical framework and new findings 显示文摘 | Nelson T O & Narens L | 1990 | The Psychology of Learning and Motivation1990，，26： | 1 |
| 19 | Formation of Stable Molecular Glasses of Yttrium (III) Acyl - DL - alaninate Complexes显示文摘 | Iida M Masuda R Naren G | 2004 | Chem Lett2004，33，11： | 1 |
| 20 | Formation of stable molecular glasses of yttrium(Ⅲ)acyl-DL-alaninate complexes显示文摘 | Iida M Masuda R Naren G | 2004 | Chem Lett2004，33，11： | 1 |
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