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146篇 您的检索式：作者名="Nariai"

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	题名	作者	年代	出处	被引量
1	Early apoptosis and cell death induced by ATX-S10Na(Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells显示文摘AIM: To investigate the roles of Bax and p53 proteins in photosensitivity of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na (Ⅱ).METHODS: HCT116 human colon cancer cells and Bax-null or p53-null isogenic derivatives were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin V assays, transmission electron microscopy assays, caspase assays and western blotting.RESULTS: Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The levels of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-xL, were decreased in Bax- and p53-independent manner.CONCLUSION: Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (Ⅱ) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-xL proteins. Our results might help in formulating new therapeutic approaches in photodynamic therapy.	Makoto Mitsunaga Akihito Tsubota Kohichi Nariai Yoshihisa Namiki Makoto Sumi Tetsuya Yoshikawa Kiyotaka Fujise	2007	World Journal of Gastroenterology2007，13，5：	3
2	FAP-1 and NF-κB expressions in oral squamous cell carcinoma as potential markers for chemo-radio sensitivity and prognosis显示文摘	Y. Nariai K. Mishima Y. Yoshimura J. Sekine	2010	International Journal of Oral & Maxillofacial Surgery2010，，4：	2
3	Severe haemodynamic stress in selected subtypes of patients with moyamoya disease:a positron emission tomography study显示文摘	Nariai T Matsushima Y Imae S	2005	Neurol Neurosurg Psychiat2005，76，5：	1
4	Meningioangiomatosis in a patient with focal epilepsy:value of PET in diagnoses and preoperative planning of surgery显示文摘	Ohta Y Nariai T Ishii K		0，，：	1
5	Preoperative evaluation of neurovascular compression in patients with trigeminal neuralgia by use of three-dimensional reconstruction from two types of high resolution magnetic resonance imaging显示文摘	Akimoto H Nagaoka T Nariai T	2002	Neuresurgery2002，51，：	1
6	Quantitative evalua- tion of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic reso- nance imaging-comparison with positron emission tomo- graphy显示文摘	Tanaka Y Nariai T Nagaoka T	2006	J Cereb Blood Flow Metab2006，26，2：	1
7	Titania-supported cobalt and nickel bimetallic catalysts for carbon dioxide reforming of methane 显示文摘	TAKANABE K NAGAOKA K NARIAI K AIKA K-I	2005	J Catal2005，232，2：	1
8	Prediction of critical heat flux for subcooled flow boiling显示文摘	Liu W Nariai H Inasaka F	2000	International Journal of Heat and Mass Transfer2000，43，18：	1
9	Preoperative evaluation of neurovascular compression in patients with trigeminal neuralgia by use of three - dimensional reconstruction from two types of high-resolution magnetic resonance imaging 显示文摘	Akimoto H Nagaoka T Nariai T	2002	Neurosurgery2002，51，4：	1
10	Preoperative evalu- ation of neurovaseular compression in patients with trigeminal neuralgia by use of three-dimensional reconstruction from two types of high-resolution magnetic resonance imaging 显示文摘	Akimoto H Nagaoka T Nariai T	2002	Neurosurgery2002，51，：	1
11	Enhanced motor cortical excitability in the unaffected hemisphere after hemispherectomy 显示文摘	Shimizu T Nariai T Maehara T	2000	Neuroreport2000，11，：	1
12	Taurine suppresses platelet - derived growth factor (PDGF) BB - induced PDGF - beta receptor phosphorylation by protein tyrosine phosphatase - mediated dephosphorylation in vascular smooth muscle cells 显示文摘	Yoshimura H Nariai Y Terashima M	2005	Biochim Biophys Acta2005，1745，3：	1
13	Mycoplasma pneumonia in{ection in hospitalized chil dren with acute pneumonia under the mycoplasma epidemic显示文摘	Nariai A	2004	Kansenshogaku Zasshi2004，78，6：	1
14	Mycoplasma pneumonia infection in hospitalized children with acute pneumonia under the Mycoplasma epidemic显示文摘	Nariai A	2004	Kansenshogaku Zasshi2004，78，6：	1
15	Preoperative evaluation of neurovascular compression in patients with trigem-nal neuralgia by use of three-dimensional reconstruction from two types of high-resolution magnetic resonance imaging显示文摘	Akimoto H Nagaoka T Nariai T	2002	Neurosurgery2002，51，4：	1
16	MycopIasma pneumoniae infection in hospitalized chiIdren with acute pneumonia under the myeoplasma epidemic 显示文摘	Nariai A	2004	Kansenshogaku Zasshi2004，78，6：	1
17	Evaluation of subcooled critical heat flux correlations for tubes with and without internal twisted tapes 显示文摘	INASAKA F NARIAI H	1996	Nuclear Engineering and Design1996，163，：	1
18	Analysis of cases of severe respiratory failure in children with influenza (H1N1) 2009 infection in Japan显示文摘	Uchimura T Mori M Nariai A		0，，01：	1
19	Voxel-and ROl-based statidtical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy 显示文摘	Ohta Y Nariai T Ishii K	2008	Ann Nucl Med2008，22，6：	1
20	Vascular reserve in chronic cerebral ischemia measured by the acetazolamide challenge test:comparison with positron emission tomography显示文摘	Nariai T Suzuki R Hirakawa K	1995	AJNR1995，16，：	1

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