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| 1 | 中日两国慢性病防控策略比较及政策启示显示文摘目的比较中日两国慢性病的防控策略,以期为快速老龄化的中国提供慢性病防控政策启示。方法全面检索中英文文献库,访问组织、机构或政府网站,查阅调查报告和会议汇编资料等,建立文献库,提取关键信息进行分析和比较。结果中日两国的慢性病防控体系差别很大。在老龄化程度极其严重的情况下,日本将癌症、心脏病、脑卒中、糖尿病等慢性病称为'生活习惯病',由此将慢性病预防对策转向更加重视个人生活习惯改善及健康促进的一级预防。通过采取'特定健康检查和特定保健指导'的'生活习惯病'防控模式,日本的慢性病防控取得了良好的效果。中国自'新医改'以来,在慢性病防控立法、多部门合作、慢性病分级管理等方面取得了一些进展,但相比日本尚有较大的差距。结论日本以预防为主的慢性病防控体系、策略和经验对我国慢性病防控具有很高的借鉴价值。 | 徐望红 张勇 王继伟 吴菲 Hiroto Narimatsu 赵根明 | 2016 | 中国慢性病预防与控制2016，24，8： | 34 |
| 2 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 3 | Determination of aflatoxins in food samples by automated on-line in-tube solid-phase microextraction coupled with liquid chromatography–mass spectrometry显示文摘 | Y. Nonaka K. Saito N. Hanioka S. Narimatsu H. Kataoka | 2009 | Journal of Chromatography A2009，，20： | 2 |
| 4 | Biological effects of blocking blue and other visible light on the mouse retina显示文摘 | Narimatsu T Ozawa Y Miyake S | 2014 | Clin Experiment Ophthalmol2014，42，6： | 1 |
| 5 | Angiomyolipoma:imaging findings in lesions with minimal fat显示文摘 | Tanimoto A Narimatsu Y | 1997 | Radiology1997，205，2： | 1 |
| 6 | The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2显示文摘 | Narimatsu S Imoto K Isobe T | 2004 | Biochem Biophys Res Commun2004，324，2： | 1 |
| 7 | Difficulty of peripheral blood stem cell collection after multiple consolidation therapy in acute myeloid leukaemia显示文摘 | Narimatsu H Yamamoto F Kurahashi S etal | 2008 | J Clin Exp Hematol2008，48，： | 1 |
| 8 | Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans显示文摘 | Harada N Okajima K Narimatsu N | 2008 | Growth Horm & IGF Res2008，18，： | 1 |
| 9 | p16 promoter hyperme-thylation in human hepatocellular carcinoma with or withouthepatitis virus infection显示文摘 | Narimatsu T Tamori A Koh N | 2004 | Intervirology2004，47，1： | 1 |
| 10 | Sumoylation differen- tially regulates Goosecoid-mediated transcriptional re- pression显示文摘 | Izzi L Narimatsu M Attisano L | 2008 | Exp Cell Res2008，314，7： | 1 |
| 11 | Effect of topical application of raspberry ketone on dermal production of insulin - like growth factor - I in mice and on hair growth and skin elasticity in humans 显示文摘 | Harada Naoaki Okajima Kenji Narimatsu Noriko | 2008 | Growth Hormone & IGF Research2008，18，： | 1 |
| 12 | Bioinformatics for comprehensive finding and analysis of glycosyltransferases显示文摘 | Kikuchi N Narimatsu H | 2006 | Biochimicaet Biophysica Acta2006，1760，： | 1 |
| 13 | Determination of daidzein and genistein in soybean foods by automated on - line in - tube solidphase microextraction coupled to high performance liquid chromatography显示文摘 | Mitani K Narimatsu S Kataoka H | 2003 | J Chromatogr A2003，986，1： | 1 |
| 14 | 显示文摘 | KATAOKA H ISEM NARIMATSUS | 2002 | JSepSci2002，25，： | 1 |
| 15 | Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24 553 patients with Hashimoto’s disease显示文摘 | Watanabe N Noh JY Narimatsu H | 2011 | Br J Haematol2011，153，2： | 1 |
| 16 | Lysine-deficient lymphotoxinalpha mutant for site-specific PEGylation 显示文摘 | Narimatsu S Yoshioka Y Watanabe H | 2011 | Cytokine2011，56，2： | 1 |
| 17 | Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto’s disease显示文摘 | Watanabe N Noh JY Narimatsu H | 2011 | Br J Haematol2011，153，2： | 1 |
| 18 | Human glycogene cloning: focus on 133- glycosyhransferase and β4-glycosyltransferase families 显示文摘 | Narimatsu H | 2006 | Curr Opin Struct Biol2006，16，5： | 1 |
| 19 | Effects of sepsis on the neuromuscular blocking actions of d-tubocurarine on rat 'adductor and abductor laryngeal muscles 显示文摘 | Nishikawa K Narimatsu E Igarashi M | 2009 | J Anesth2009，23，4： | 1 |
| 20 | Angiomyolipoma: imaging findings in lesions with minimal fat 显示文摘 | Jinzaki M Tanimoto A Narimatsu Y | 1997 | Radiolo~1997，205，2： | 1 |
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