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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C显示文摘AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to IFN.METHODS:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively determined.RESULTS: Twenty-five patients completed IFN therapy.Eight patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy subjects.In vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C. | Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki | 2004 | World Journal of Gastroenterology2004，10，5： | 12 |
| 3 | Clinicopathological features of small T1 colorectal cancers显示文摘BACKGROUND Although small colorectal neoplasms(<10 mm)are often easily resected endoscopically and are considered to have less malignant potential compared with large neoplasms(≥10 mm),some are invasive to the submucosa.AIM To clarify the clinicopathological features of small T1 colorectal cancers.METHODS Of 32025 colorectal lesions between April 2001 and March 2018,a total of 1152 T1 colorectal cancers resected endoscopically or surgically were included in this study and were divided into two groups by tumor size:a small group(<10 mm)and a large group(≥10 mm).We compared clinicopathological factors including lymph node metastasis(LNM)between the two groups.RESULTS The incidence of small T1 cancers was 10.1%(116/1152).The percentage of initial endoscopic treatment in small group was significantly higher than in large group(<10 mm 74.1%vs≥10 mm 60.2%,P<0.01).In the surgical resection cohort(n=798),the rate of LNM did not significantly differ between the two groups(small 12.3%vs large 10.9%,P=0.70).In addition,there were also no significant differences between the two groups in pathological factors such as histological grade,vascular invasion,or lymphatic invasion.CONCLUSION Because there was no significant difference in the rate of LNM between small and large T1 colorectal cancers,the requirement for additional surgical resection should be determined according to pathological findings,regardless of tumor size. | Yuki Takashina Shin-Ei Kudo Katsuro Ichimasa Yuta Kouyama Kenichi Mochizuki Yoshika Akimoto Yasuharu Maeda Yuichi Mori Masashi Misawa Noriyuki Ogata Toyoki Kudo Tomokazu Hisayuki Takemasa Hayashi Kunihiko Wakamura Naruhiko Sawada Toshiyuki Baba Fumio Ishida Kazunori Yokoyama Mitsuru Daita Tetsuo Nemoto Hideyuki Miyachi | 2021 | World Journal of Clinical Cases2021，9，33： | 1 |
| 4 | In vivo evidence of CHIP up-regulation attenuating tau aggregation显示文摘 | Naruhiko S Miyuki M Tatsuya M | 2005 | J Neruochem2005，94，： | 1 |
| 5 | Efficient sensitization of nanocrystalline TiO2 films with high molar extinction coefficient ruthenium complex显示文摘 | Ke-Jian Jiang Jiang-bin Xia Naruhiko Masaki | 2008 | Inorganica Chimica2008，361，： | 1 |
| 6 | Aluminum Induces Tau Aggregation in vitro but not in vivo显示文摘 | Tatsuya Mizoroki Shunsuke Meshitsuka Sumihiro Maeda Miyuki Murayama Naruhiko Sahara Akihiko Takashima | 2007 | Journal of Alzheimer’s Disease2007，，： | 1 |
| 7 | Retardation of crack initiation and growth in austenitic stainless steels by laser peening without protective coating 显示文摘 | Yuji Sano Minoru Obata Tatsuya Kubo Naruhiko Mukaia Masaki Yoda Kiyotaka Masaki Yasuo Ochi | 2006 | Materials Science and Engineering A2006，，417： | 1 |
| 8 | Fabrication and characterization of thin Nb2O5 blocking layers for ionic liquid-based dye-sensitized solar cells显示文摘 | Xia J B Naruhiko M Jiang K J | 2007 | J Photochem Photobiol A: Chem2007，188，： | 1 |
| 9 | Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets显示文摘AIM: To investigate the effects of taurolithocholate (TLC)on the canalicular motility in isolated rat hepatocyte cou-plets (IRHC).METHODS: TLC was added to IRHC at concentrationsof 10 and 50 μmol/L, respectively. In each group, fi vetime-lapse movies containing 3 representative bile cana-liculi were taken under phase-contrast microscopy for12 h. The number of bile canalicular contractions andthe intervals between consecutive canalicular contrac-tions were calculated. Furthermore, the effects of TLC onIRHC were examined by transmission electron micros-copy.RESULTS: The bile canalicular contractions were spon-taneous and forceful in the controls. Active vesicularmovement was observed in the pericanalicular region.Immediately after the addition of TLC, the bile canaliculiwere deformed, and canalicular bile was incorporatedinto the vacuoles. The canaliculi were gradually dilated,and canalicular contractions were markedly inhibited byTLC. The vesicular movements became extremely slowin the pericanalicular region. The number of canalicularcontractions significantly decreased in the TLC-treatedgroups, as compared with that in the controls. The timeintervals were prolonged, as the TLC dosage increased,indicating that bile secretion into the canaliculi wasimpaired with TLC. Transmission electron microscopyrevealed the lamellar transformation of the canalicularmembranes in IRHC treated with TLC.CONCLUSION: TLC impairs both the bile canalicularcontractions and the canalicular bile secretion, possiblyby acting directly on the canalicular membranes in TLC-induced cholestasis. | Norihito Watanabe Tatehiro Kagawa Sei-ichiro Kojima Shinji Takashimizu Naruhiko Nagata Yasuhiro Nishizaki Tetsuya Mine | 2006 | World Journal of Gastroenterology2006，12，33： | 1 |
| 10 | Dissociation of Vasoreactivity to Acetazolamide and Hypercapnia:Comparative Study in Patients With Chronic Occlusive Major Cerebral Artery Disease显示文摘 | Tanaka Naruhiko Ishikawa Tatsuya | 1996 | Stroke1996，27，： | 1 |
| 11 | Contamination by persistent organochlorines in small cetaceans from HongKong coastal waters显示文摘 | MINH T B WATANABE M NARUHIKO H | 1999 | Mar Pollut Bull1999，39，4： | 1 |
| 12 | Familial occurrence of moyamoya disease显示文摘 | Kiyohiro Houkin Naruhiko Tanaka Akihiro Takahashi Hiroyasu Kamiyama Hiroshi Abe Naofumi Kajii | 1994 | Child’s Nervous System1994，，7： | 1 |
| 13 | Cellular Models for Tau Filament Assembly显示文摘 | Liwen Ko Michael Deture Naruhiko Sahara | 2002 | Journal of Molecular Neuroscience2002，19，： | 1 |
| 14 | Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease显示文摘 | Alix de Calignon Manuela Polydoro Marc Suárez-Calvet Christopher William David H. Adamowicz Kathy J. Kopeikina Rose Pitstick Naruhiko Sahara Karen H. Ashe George A. Carlson Tara L. Spires-Jones Bradley T. Hyman | 2012 | Neuron2012，，4： | 1 |
| 15 | Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP显示文摘 | Hiroo Nakajima Naruhiko Mizuta Koichi Sakaguchi Ikuya Fujiwara Atsushi Yoshimori Junji Magae Sei-ichi Tanuma | 2010 | Journal of Bioscience and Bioengineering2010，，2： | 1 |
| 16 | Retardation of crack initiation and growth in austenitic stainless steels by laser peening without protective coating显示文摘 | Yuji Sano Minoru Obata Tatsuya Kubo Naruhiko Mukai Masaki Yoda Kiyotaka Masaki Yasuo Ochi | 2005 | Materials Science & Engineering A2005，，1： | 1 |
| 17 | A high incidence of apolipoprotein E ε4 allele in middle-aged non-demented subjects with cerebral amyloid β protein deposits显示文摘 | T. Arai Kenji Ikeda Haruhiko Akiyama Chie Haga Mihoko Usami Naruhiko Sahara Shuji Iritani Hiroshi Mori | 1999 | Acta Neuropathologica1999，，1： | 1 |
| 18 | Current Status of Seismic Isolation and Technology of Elastomeric Isolators in Japan显示文摘This article introduces about the seismic isolation (SI) and technology of the elastomeric isolator in Japan. At first, the performance of SI buildings during Tohoku District-Off the Pacific Ocean Earthquake 2011 is briefly summarized. Then, the principle of seismic isolation, and technology of elastomeric seismic protection isolators are introduced. Finally, the future direction of the technology is described focusing on the development of specifications for elastomeric isolators. | Toshio Nishi Naruhiko Mashita Nobuo Murota | 2012 | 中国橡胶2012，28，4： | 0 |
| 19 | Multifocal intraportal invasion of breast carcinoma diagnosed by laparoscopy-assisted liver biopsy显示文摘Hepar lobatum carcinomatosum (HLC) is defined as an acquired hepatic deformity consisting of an irregularly lobulated hepatic contour caused by intravascular infiltration of metastatic carcinoma. To date, only nine cases of HLC have been reported in the literature. We report a case of a 68-year-old woman showing hepatic metastasis of breast carcinoma in radiologically unidentified form. Initially, she received left partial mastectomy for breast cancer but solid hepatic metastases were identified in S2 and S6, 9 mo after surgery. Then, they responded to chemotherapy and radiologically disappeared. After radiological disappearance of the liver tumors, the patient's blood chemistry showed abnormal liver function. A CT scan demonstrated heterogeneous enhancement effect in the liver in the late phase,suggesting uneven hepatic blood supply. Hepatic deformity was not obvious. Laparoscopy revealed a slightly deformed liver surface with multiple indentations and shallow linear depressions. Furthermore, a wide scar was observed on the surface of S2 possibly at the site where the metastatic tumor existed before chemotherapy. Liver biopsy from the wide scar lesion showed intraportal tumor thrombi with desmoplastic change. Because of its similarity to the histology of the original breast cancer, we concluded that the hepatic functional abnormalities and slightly deformed liver surface were derived from the circulatory disturbance caused by microscopic tumor thrombi. Besides, since the wide scar was located at the site of the pre-existing tumor,it is probable that chemotherapy was an important cause of fibrous scarring as a result of tumor regression. These morphologic findings are compatible with those of HLC.Laparoscopy-assisted liver biopsy was useful to make definite diagnosis, even though the hepatic deformity was radiologically undetectable. | Tomoki Nakajima Satoru Sekoguchi Taichirou Nishikawa Hidetaka Takashima Tadashi Watanabe Masahito Minami Yoshito Itoh Naruhiko Mizuta Hiroo Nakajima Takeshi Mazaki Akio Yanagisawa Takeshi Okanoue | 2005 | World Journal of Gastroenterology2005，11，15： | 0 |
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