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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Current role of minimally invasive approaches in the treatment of early gastric cancer显示文摘Despite declining incidence,gastric cancer remains one of the most common cancers worldwide.Early detection in population-based screening programs has increased the number of cases of early gastric cancer,representing approximately 50%of newly detected gastric cancer cases in Asian countries.Endoscopic mucosal resection and endoscopic submucosal dissection have become the preferred therapeutic techniques in Japan and Korea for the treatment of early gastric cancer patients with a very low risk of lymph node metastasis.Laparoscopic and robotic resections for early gastric cancer,including function-preserving resections,have propagated through advances in technology and surgeon experience.The aim of this paper is to discuss the recent advances in minimally invasive approaches in the treatment of early gastric cancer. | Abraham El-Sedfy Savtaj S Brar Natalie G Coburn | 2014 | World Journal of Gastroenterology2014，20，14： | 15 |
| 3 | 滋养细胞组织 GATA-3表达:445例免疫组化及其诊断应用分析显示文摘GATA-3主要表达在乳腺癌和尿路上皮癌,而在正常或病变滋养细胞组织中的表达报道甚少。作者选取445例正常/病变滋养细胞组织及其肿瘤进行 GATA-3免疫组化评估,根据着色强弱标记为(-~-),探讨GATA-3在下列组织中的表达意义。这些组织包括孕囊/中晚期妊娠胎盘/异位妊娠、葡萄胎、胎盘结节、正常/异常植入部位、绒毛膜癌、上皮样滋养细胞肿瘤、胎盘滋养细胞肿瘤、非典型平滑肌瘤(含平滑肌肉瘤)、子宫颈和肺的鳞状细胞癌。 | Natalie B Allen M G Ie-Ming S 许文静 余英豪 | 2015 | 临床与实验病理学杂志2015，31，9： | 11 |
| 4 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 5 | Thermal maturity of the Barnett Shale determined from well-log analysis 显示文摘 | Hank Z Natalie B G Brad C | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 6 | Metabolic syndrome: at the crossroads of cardiorenal risk显示文摘 | Natali A Pucci G Boldrini B | 2009 | J Nephrol2009，22，1： | 1 |
| 7 | Appraising eardiotoxi- city associated with liposomal doxorubicin by means of tissue Doppler echocardiography end-points: rationale and design of the LITE ( Liposomal doxorubicin-Investigational chemotherapy-Tissue Doppler imaging Evaluation) randomized pilot study 显示文摘 | Lotrionte M Palazzoni G Natali R | 2009 | Int J Cardiol2009，135，1： | 1 |
| 8 | Nuclear DNA variability within Pisum sativum (Leguminosae) :nucleotypic effects on plant growth显示文摘 | CAVALLINI A NATALI L CIONINI G | 1993 | Heredity1993，70，： | 1 |
| 9 | Electrochemical anticorrosion performance evaluation of A1203 coatings deposited by MOCVD on an industrial brass substrate 显示文摘 | GUIDI F MORETTI G CARTA G NATALI M ROSSETTO G PIER1NO Z SALMASO G RIGATO V | 2005 | Electrochimica Acta2005，50，： | 1 |
| 10 | Prevention of cardiac hypertrophy in mice by calcineurin inhibition显示文摘 | Mark AS Hae WL Natalie G | 1998 | Science1998，281，1： | 1 |
| 11 | Numerical analysis of tooth mobility: Formulation of a non-linear constitutive law for the periodontal ligament 显示文摘 | Natali A N Pavan P G Scarpa C | 2004 | Dental Materials2004，20，7： | 1 |
| 12 | Community pharmacists' opinions about having diagnostic data provided with prescriptions显示文摘 | EDWARD P ARMSTRONG NATALIE M G | 2003 | J Pharm Pract2003，16，5： | 1 |
| 13 | Experimental- numerical analysis of minipig's multi-rooted teeth 显示文摘 | Natali A N Camiel E L Pavan P G | 2007 | Journal of Biomechanies2007，40，8： | 1 |
| 14 | Isolation and characteriza- tion of rufoxin, a novel protein exhibiting neurotoxicity from venom of the psammophiine, Rhamphiophis oxyrhynehus ( Rufous beaked snake) 显示文摘 | Natalie G Lumsden Yajnavalka | 2007 | Neuropharmacology2007，52，4： | 1 |
| 15 | Improvements of atherosclerosis and hepatic oxidative stress are independent of exercise intensity in LDLr(-/-) mice 显示文摘 | Teodoro B G Natali A J Fernandes S A | 2012 | Atheroscler Thromb2012，19，10： | 1 |
| 16 | Epidemiological chronorisk of stroke显示文摘 | Pasqualetti P Natali G Casale R | 1990 | Aeta N eurol Stand1990，81，1： | 1 |
| 17 | Distribution and molecular characterization of a cell-surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies显示文摘 | Wilson B S Imai K Natali P G | 1981 | Int J Cancer1981，28，3： | 1 |
| 18 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 19 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 20 | Thermal maturity of the Barnett shale determined from well-log analysis 显示文摘 | Hank Zhao Natalie B G Brad Curtis | 2007 | AAPG Bulletin2007，91，4： | 1 |
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