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| 1 | Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis显示文摘AIM To characterize natural history of cryptogenic cirrhosis(CC) and compare its clinical features and outcomes to those of hepatitis C virus(HCV)-related cirrhosis.METHODS A prospective cohort of 102 consecutive patients at their first diagnosis of CC were enrolled in this study. The clinical data and outcomes were compared to an ageand Child-pugh class-matched cohort of 110 patients with HCV-related cirrhosis. Diagnosis of cirrhosis was based on compatible clinical and laboratory parameters, ultrasound/endoscopic parameters and, whenever possible, on histological grounds and transient elastography. All cases of cirrhosis without a definite etiology were enrolled in the CC group. The parameters assessed were:(1) severity of liver disease at the time of first diagnosis;(2) liver decompensation during follow-up;(3) hepatocellular carcinoma(HCC);(4) orthotopic liver transplantation; and(5) death. The independent associated factors were evaluated by multiple logistic regression analysis, and survival and its determinants by the Kaplan-Meier model, log-rank test and Cox regression.RESULTS At the first observation, median age was 66 and 65 years and male gender was 36% and 58% for CC and HCV cirrhosis, respectively. CC showed Child-pugh class A/B/C of 47%/31%/22%, respectively. Compared to HCV cirrhosis, CC exhibited a significantly higher prevalence of metabolic syndrome(12% vs 54%, respectively), overweight/obesity, high BMI, impaired glucose tolerance, high blood pressure, dyslipidemia, hyperuricemia, cardiovascular diseases, extrahepatic cancer, and gallstones. Over a median period of 42 mo of follow-up, liver decompensation, HCC development and death for CC and HCV-related cirrhosis were 60.8%, and 54.4%, 16.7% and 17.2%, 39.2% and 30%, respectively. The median survival was 60 mo for CC. Independent predictors of death were age and Childpugh class at diagnosis. CC showed an approximately twofold higher incidence of HCC in Child-pugh class A.CONCLUSION Undiagnosed nonalcoholic fatty liver disease has an etiologic role in CC that is associated with a poor prognosis, early HCC development, high risk of cardiovascular disease and extrahepatic cancer. | Luca Rinaldi Fabio Nascimbeni Mauro Giordano Chiara Masetti Barbara Guerrera Annalisa Amelia Maria Chiara Fascione Stefano Ballestri Dante Romagnoli Rosa Zampino Riccardo Nevola Enrica Baldelli Natalina Iuliano Valerio Rosato Amedeo Lonardo Luigi Elio Adinolfi | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 2 | Vesical dysfunctions after radical hysterectomy for cervical cancer: a critical review显示文摘 | Marzio Angelo Zullo Natalina Manci Roberto Angioli Ludovico Muzii Pierluigi Benedetti Panici | 2003 | Critical Reviews in Oncology and Hematology2003，，3： | 4 |
| 3 | Solitary gastric recur- rence from ovarian carcinoma:A case report and literature review 显示文摘 | Milena P Natalina M Claudia M | 2006 | Surg Oncol2006，15，： | 1 |
| 4 | Knowledge, attitude and practice in primary and secondary cervical cancer prevention among young adult Italian women显示文摘 | Serena Donati Cristina Giambi Silvia Declich Stefania Salmaso Antonietta Filia Marta Luisa Ciofi degli Atti Maria Pia Alibrandi Silvia Brezzi Francesca Carozzi Natalina Collina Daniela Franchi Amedeo Lattanzi Margherita Meda Maria Carmela Minna Roberto Na | 2012 | Vaccine2012，，： | 1 |
| 5 | Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury显示文摘 | Baoyuan Bi Natalina S Mila K | | 0，，： | 1 |
| 6 | An update in neoadjuvant chemotherapy in cervical cancer显示文摘 | Pieluigi Benedetti Panici Filippo Bellati Maria Pastore Natalina Manci Angela Musella Simona Pauselli Michela Angelucci Ludovico Muzii Roberto Angioli | 2007 | Gynecologic Oncology2007，，1： | 1 |
| 7 | Neoadjuvant Chemotherapy Followed by Radical Surgery in Patients Affected by FIGO Stage IVA Cervical Cancer显示文摘 | Pierluigi Benedetti Panici Filippo Bellati Natalina Manci Milena Pernice Francesco Plotti Violante Di Donato Marco Calcagno Marzio Angelo Zullo Ludovico Muzii Roberto Angioli | 2007 | Annals of Surgical Oncology2007，，9： | 1 |
| 8 | Test-based exclusion diets in gastro-esophageal reflux disease patients:A randomized controlled pilot trial显示文摘AIM:To investigate the clinical response of gastroesophageal reflux disease(GERD)symptoms to exclusion diets based on food intolerance tests.METHODS:A double blind,randomized,controlled pilot trial was performed in 38 GERD patients partially or completely non-responders to proton pump inhibitors(PPI)treatment.Fasting blood samples from each patients were obtained;leukocytotoxic test was performed by incubating the blood with a panel of 60food items to be tested.The reaction of leukocytes(rounding,vacuolization,lack of movement,flattening,fragmentation or disintegration of cell wall)was then evaluated by optical microscopy and rated as follows:level 0=negative,level 1=slightly positive,level 2=moderately positive,and level 3=highly positive.A'true'diet excluding food items inducing moderatesevere reactions,and a'control'diet including them was developed for each patient.Then,twenty patients received the'true'diet and 18 the'control'diet;after one month(T1)symptoms severity was scored by the GERD impact scale(GIS).Hence,patients in the'control'group were switched to the'true'diet,and symptom severity was re-assessed after three months(T2).RESULTS:At baseline(T0)the mean GIS global score was 6.68(range:5-12)with no difference between'true'and control group(6.6±1.19 vs 6.7±1.7).All patients reacted moderately/severely to at least 1 food(range:5-19),with a significantly greater number of food substances inducing reaction in controls compared with the'true'diet group(11.6 vs 7.0,P<0.001).Food items more frequently involved were milk,lettuce,brewer’s yeast,pork,coffee,rice,sole asparagus,and tuna,followed by eggs,tomato,grain,shrimps,and chemical yeast.At T1 both groups displayed a reduction of GIS score('true'group 3.3±1.7,-50%,P=0.001;control group 4.9±2.8,-26.9%,P=0.02),although the GIS score was significantly lower in'true'vs'control'group(P=0.04).At T2,after the diet switch,the'control'group showed a further reduction in GIS score(2.7±1.9,-44.9%,P=0.01),while the'true'group did not(2.6±1.8,-21.3%,P=0.19),so that the GIS scores didn’t differ between the two groups.CONCLUSION:Our results suggest that food intolerance may play a role in GERD symptoms development,and leucocytotoxic test-based exclusion diets may be a possible therapeutic approach when PPI are not effective or indicated. | Michele Caselli Giovanni Zuliani Francesca Cassol Nadia Fusetti Elena Zeni Natalina Lo Cascio Cecilia Soavi Sergio Gullini | 2014 | World Journal of Gastroenterology2014，20，45： | 1 |
| 9 | Neoadjuvant Chemotherapy Followed by Radical Surgery in Patients Affected by FIGO Stage IVA Cervical Cancer显示文摘 | Pierluigi Benedetti Panici MD Filippo Bellati MD Natalina Manci MD Milena Pernice MD Francesco Plotti MD Violante Di Donato MD Marco Calcagno MD Marzio Angelo Zullo MD Ludovico Muzii MD Roberto Angioli MD | 2007 | Annals of Surgical Oncology2007，，9： | 1 |
| 10 | Solitary gastric re- currence from ovarian carcinoma:A report and literature re- view 显示文摘 | Milena P Natalina M Claudia M | 2006 | Surg Oncol2006，15，4： | 1 |
| 11 | Identification of chemical clusters discriminatiors of the roast dgree in Arabica and Robusta coffee beans显示文摘 | NATALINA C B ANTONIO E L JOSE Cochicho Ramalho | | 0，，02： | 1 |
| 12 | Phytosterol-Enriched Yogurt Increases LDL Affinity and Reduces CD36 Expression in Polygenic Hypercholesterolemia显示文摘 | Gianluca Ruiu Silvia Pinach Fabrizio Veglia Roberto Gambino Saverio Marena Barbara Uberti Natalina Alemanno Davina Burt Gianfranco Pagano Maurizio Cassader | 2009 | Lipids2009，，2： | 1 |
| 13 | Neoadjuvant Chemotherapy Followed by Radical Surgery in Patients Affected by FIGO Stage IVA Cervical Cancer显示文摘 | Pierluigi Benedetti Panici MD Filippo Bellati MD Natalina Manci MD Milena Pernice MD Francesco Plotti MD Violante Di Donato MD Marco Calcagno MD Marzio Angelo Zullo MD Ludovico Muzii MD Roberto Angioli MD | 2007 | Annals of Surgical Oncology2007，，9： | 1 |
| 14 | Designing Locally Relevant Instructional Material for Indonesian EFL Classroom显示文摘Meaningful teaching and learning can be achieved when the materials are closely related to the learners’real life.This research focuses on language and culture for the materials suitable for the first semester students of EFL class at the University of Palangka Raya.The design-based research was applied to provide sources consisting of environmental linguistic expres-sions within the eco-linguistic perspective and using a text-based or gen-re-based approach by selecting suitable texts for the level.The Product of Instructional Material shows at least two benefits:(1)as the source of the main module of Intensive Course in writing skill for the first-year students of English Education in Central Kalimantan,and(2)the solution for en-couraging the teachers to modify the provided material which can cover the national standard(KKNI)as well as promoting the local values to strength-en local cultures to have meaningful teaching and learning process. | Natalina Asi Maria A.Luardini Merilyn Simbolon | 2022 | Journal of Linguistics and Education Research2022，5，1： | 0 |
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