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| 1 | How can we harness quantitative genetic variation in crop root systems for agricultural improvement?显示文摘Root systems are a black box obscuring a comprehensive understanding of plant function,from the ecosystem scale down to the individual. In particular,a lack of knowledge about the genetic mechanisms and environmental effects that condition root system growth hinders our ability to develop the next generation of crop plants for improved agricultural productivity and sustainability. We discuss how the methods and metrics we use to quantify root systems can affect our ability to understand them,how we can bridge knowledge gaps and accelerate the derivation of structurefunction relationships for roots,and why a detailed mechanistic understanding of root growth and function will be important for future agricultural gains. | Christopher N.Topp Adam L.Bray Nathanael A.Ellis Zhengbin Liu | 2016 | Journal of Integrative Plant Biology2016，58，3： | 5 |
| 2 | When Kinases Meet PROTACs显示文摘 | Li Tan Nathanael S. Gray | 2018 | Chinese Journal of Chemistry2018，36，10： | 3 |
| 3 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 4 | DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival显示文摘 | Timothy R. Peterson Mathieu Laplante Carson C. Thoreen Yasemin Sancak Seong A. Kang W. Michael Kuehl Nathanael S. Gray David M. Sabatini | 2009 | Cell2009，，5： | 2 |
| 5 | A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction显示文摘早熟的出生的率是惊人的并且威胁社会和世界范围的保健系统。早产在超过 50% 盒子导致早熟的出生。Preterm 出生说明婴儿病态和死亡的 three-quarters。在 34 星期怀孕期前熬过出生的孩子经常面对终生的残疾。为劳动正在想要的 preterm 的当前的处理。没有处理被发现了通常有效,任何一个都系统地没在 48 h 以外被评估。preterm 劳动的处理的新途径绝望地被需要。从我们的实验室的最近的研究建议子宫的肌肉是有不同于另外的光滑的肌肉的子宫的松驰的规定的唯一的分隔空间。这里,我们讨论最近的证据机械地激活的 2 毛孔钾隧道, TREK-1,可以贡献在子宫的光滑的肌肉和变体与人的劳动联系了的那 TREK-1 基因发信号的收缩松驰, preterm 劳动可以导致 preterm 劳动和它的可能的预防的更好的理解。 | Iain L O BUXTON Nathanael HEYMAN Yi-ying WU Scott BARNETT Craig ULRICH | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 6 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 7 | Tandem amine propargylation-Sonogashira reactions: new threecomponent coupling leading to functionalized substituted propargylic amines 显示文摘 | Nathanael Olivi Philippe Spruyt Jean-Francois Peyrat | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 8 | Broad spectrum alkynyl inhibitors of T315I Bcr-Abl显示文摘 | Xianming Deng Sang Min Lim Jianming Zhang Nathanael S. Gray | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，14： | 1 |
| 9 | Evolving technologies for growing,imaging and analyzing 3D root system architecture of crop plants显示文摘A plant's ability to maintain or improve its yield under limiting conditions,such as nutrient de ficiency or drought,can be strongly in fluenced by root system architecture(RSA),the three-dimensional distribution of the different root types in the soil. The ability to image,track and quantify these root system attributes in a dynamic fashion is a useful tool in assessing desirable genetic and physiological root traits. Recent advances in imaging technology and phenotyping software have resulted in substantive progress in describing and quantifying RSA. We have designed a hydroponic growth system which retains the three-dimensional RSA of the plant root system,while allowing for aeration,solution replenishment and the imposition of nutrient treatments,as well as high-quality imaging of the root system. The simplicity and flexibility of the system allows for modi fications tailored to the RSA of different crop species and improved throughput. This paper details the recent improvements and innovations in our root growth and imaging system which allows for greater image sensitivity(detection of fine roots and other root details),higher ef ficiency,and a broad array of growing conditions for plants that more closely mimic those found under field conditions. | Miguel A.Pieros Brandon G.Larson Jon E.Shaff David J.Schneider Alexandre Xavier Falcao Lixing Yuan Randy T.Clark Eric J.Craft Tyler W.Davis Pierre-Luc Pradier Nathanael M.Shaw Ithipong Assaranurak Susan R.Mc Couch Craig Sturrock Malcolm Bennett Leon V.Kochian | 2016 | Journal of Integrative Plant Biology2016，58，3： | 1 |
| 10 | Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore显示文摘 | Nathanael Larochette Didier Decaudin Etienne Jacotot Catherine Brenner Isabel Marzo Santos A. Susin Naoufal Zamzami Zhihua Xie John Reed Guido Kroemer | 1999 | Experimental Cell Research1999，，： | 1 |
| 11 | Targeting cancer with small molecule kinase inhibitors显示文摘 | ZHANG JM PRISCILLA LY NATHANAEL SG | 2009 | Cancer2009，9，1： | 1 |
| 12 | Effect of ZnO nanoparticles mor- phology on UV blocking of poly(vinyl alcohol)/ZnO composite nanofibers显示文摘 | IM Young Min OH Tae Hwan NATHANAEL Joseph A | 2015 | Materials Letters2015，147，： | 1 |
| 13 | Stable isotope composition of walleye: ^15N accumulation with age and area-specific differences in δ^13 C 显示文摘 | NATHANAEL C O DONNA L P | 2001 | Can J Fish Aquat Sci2001，58，： | 1 |
| 14 | Muiti-dimen-sional sensing for impact load and damage evaluation ina carbon filament wound canister显示文摘 | Nathanael C Y Douglas E A Matt T | 2008 | Material Evalua-tion2008，，7： | 1 |
| 15 | Work Practices and Prescription: A Key Issue for Organizational Resilience显示文摘 | Nathanael D Man aaras N | 2008 | Ashgate Publishing2008，01，9： | 1 |
| 16 | Revealing the residual stress distribution in laser welded Eurofer97 steel by neutron diffraction and Bragg edge imaging显示文摘Eurofer97 steel is a primary structural material for applications in fusion reactors. Laser welding is a promising technique to join Eurofer97 plasma-facing components and overcome remote handling and maintenance challenges. The interaction of the induced residual stress and the heterogeneous microstructure degrades the mechanical performance of such fusion components. The present study investigates the distribution of residual stress in as-welded and post-heat treated Eurofer97 joints. The mechanistic connections between microstructure, material properties, and residual stress are also studied. Neutron diffraction is used to study the through-thickness residual stress distribution in three directions,and neutron Bragg edge imaging(NBEI) is applied to study the residual strain in high spatial resolution.The microstructures and micro-hardness are characterised by electron backscatter diffraction and nanoindentation, respectively. The M-shaped residual stress distribution through the thickness of the as-welded weldment is observed by neutron diffraction line scans over a region of 1.41 × 10 mm^(2). These profiles are cross-validated over a larger area(∼56 × 40 mm^(2)) with the higher spatial resolution by NBEI. The micro-hardness value in the fusion zone of the as-welded sample almost doubles from 2.75 ± 0.09 GPa to 5.06 ± 0.29 GPa due to a combination of residual stress and cooling-induced martensite. Conventional post weld heat treatment(PWHT) is shown to release ∼90% of the residual stress but not fully restore the microstructure. By comparing its hardness with that of stress-free samples, it is found that the microstructure is the primary contribution to the hardening. This study provides insight into the prediction of structural integrity for critical structural components of fusion reactors. | Bin Zhu Nathanael Leung Winfried Kockelmann Saurabh Kabra Andrew JLondon Michael Gorley Mark JWhiting Yiqiang Wang Tan Sui | 2022 | Journal of Materials Science & Technology2022，，19： | 1 |
| 17 | Chloramphenicol residues in albumen and yolk of hen′s eggs after experimental administration显示文摘 | Tsoukali-Papadopoulou H Nathanael B | 1998 | Archiv-fur-Geflugelkunde1998，62，2： | 1 |
| 18 | Investigations on the Mechanism of Action of the Novel Antitumor Agents 2‐Benzothiazolyl, 2‐Benzoxazolyl, and 2‐Benzimidazolyl Hydrazones Derived from 2‐Acetylpyridine显示文摘 | Nathanael J.Peaty Jennifer R.Henry JohnnyEasmon GottfriedHeinisch GerhardPürstinger | 1999 | Arch. Pharm. Pharm. Med. Chem1999，，4： | 1 |
| 19 | Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitor显示文摘 | ong-Tae Chang Nathanael S Gray | 1999 | Chemistry & Bioogy1999，6361，： | 1 |
| 20 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
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