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23篇 您的检索式：作者名="Nazli J"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Epithelia under metabolic stress perceive commensal bacteria as a threat显示文摘	NAZLI A YANG Pingchang JURY J	2004	The American Journal of Pathology2004，164，3：	1
3	A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the north west frontier province -Pakistan 显示文摘	JAN MR NAZLI R SHAH J	2012	Hypertens Pregnancy2012，31，2：	1
4	HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium 显示文摘	Nazli A Kafka J K Ferreira V H	2013	J Immnnol2013，191，8：	1
5	Epithelia under metabolic stress perceive commensal bacteria as a threat显示文摘	Nazli A Yang PC Jury J	2004	Am J Pathol2004，164，3：	1
6	HIV-1 gpl20 induces TLR2- and TLR4- mediated innate immune activation in human female genital epithelium显示文摘	Nazli A Kafka J K Ferreira V H Anipindi V Muel- ler K Osborne B J Dizzell S Chauvin S Mian M F Ouellet M Tremblay M J Mossman K L Ashkar A A Kovacs C Bowdish D M Snider D P Kaul R Kaushic C	2013	J Immunol2013，191，8：	1
7	Cerebral vasoepasm after subarachnoid hemorrhage显示文摘	Nazli J Mayer S	2003	CurrOpen Crit Care2003，9，2：	1
8	Cerebral vasospasm after subarachnoid hemorrhage显示文摘	Nazli J Mayer SA	2003	Curt Opin Crit Care2003，9，2：	1
9	A study of lipoproteins in nor-mal and pregnancy induced hypertensive women in tertiary carehospitals of the north west frontier province-Pakistan 显示文摘	Jan M R Nazli R Shah J	2012	Hyper-tens Pregnancy2012，31，2：	1
10	Cerebral vasospasm after subaracnoid hemorrhage 显示文摘	Nazli J Mayer S	2003	Cur Opin Crit Care2003，9，：	1
11	Cerebral vasospasm after subarachnoid hemorrhage显示文摘	Nazli J Mayer S	2003	CurrOpen Crit Care2003，9，2：	1
12	Cerebral vasospasm after subarachnoid hemorrhage显示文摘	Mayer S	2003	Curr Opin Cfit Care2003，9，2：	1
13	Predictors and impact of aneurysm rebleeding after subarachnoid hemorrhage 显示文摘	Andrew M Naidech Nazli J	2005	Arch Neuro2005，62，4：	1
14	Cerebral vasospasm after subaracnoid hemorrhage显示文摘	Nazli J Mayer S	2003	Curr Opin Crit Care2003，9，2：	1
15	Predictors and impact of aneurysm rebleeding after subarachnoid hemorrhage显示文摘	Nazli J Kurt TK	2005	Arch Neurol2005，62，：	1
16	Cerebral vasospasm after subarachnoid hemorrhage 显示文摘	Nazli J Mayer S	2003	Curr Opin Crit Care2003，9，：	1
17	A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the North West Frontier Province-Pakistan 显示文摘	Jan MR Nazli R Shah J	2012	Hypertens Pregnancy2012，31，2：	1
18	Inherited thrombophilia: diagnosis and anticoagulation treatment in pregnancy显示文摘	Nazli Hossain Michael J Paidas	2013	Clinics in Laboratory Medicine2013，33，2：	1
19	Epithelia under metabolic stress perceive commensal bacteria as a threat 显示文摘	Nazli A Yang PC Jury J	2004	Am J Pathol2004，164，3：	1
20	Cerebral vasospasm after subarachnoid hem-orrhage显示文摘	Nazli J Mayer S	2003	Curropen Crit Care2003，9，2：	1

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