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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | Anti-Mullerian hormone-a prognostic marker for metformin therapy efficiency in the treatment of women with infertility and polycystic ovary syndrome 显示文摘 | Neagu M Cristescu C | 2012 | J Med Life2012，5，： | 1 |
| 3 | Patented biomark- er panels in early detection of cancer 显示文摘 | Neagu M Constantin C Tanase C | 2011 | Recent Patents on Biomarkers2011，1，1： | 1 |
| 4 | Characterization of a planar microcoil for implantable microsystems显示文摘 | Neagu C R Jansen H V Smith A | 1997 | Sensors and Actuators Physical1997，207，123： | 1 |
| 5 | Patented biomarker panels in early detection of cancer显示文摘 | Neagu M Constantin C Tanase C | 2011 | Recent Patents on Biomark2011，1，1： | 1 |
| 6 | Fundamentals on face milling processing of straight shafts显示文摘 | Neagu C Gheorghe M Dumitrescu A | 2005 | Journal of Materials Processing Technology2005，166，3： | 1 |
| 7 | Trade in international maritime services: how much does policy matter?显示文摘 | Fink C Mat-too A Neagu I C | 2002 | The Worm Bank Economic Review2002，16，1： | 1 |
| 8 | Anti - Mtillerian hormone - a prognostic marker for mefformin therapy efficiency in the treatment of women with infertility and polycystic ovary syndrome 显示文摘 | Neagu M Cristescu C | 2012 | J Med Life2012，5，4： | 1 |
| 9 | Effect ofP,Ti+B and mixed metals on the microstructure and mechanical properties of the hypereutectic Al-Si alloy显示文摘 | GURGU C NEAGU C JULA G H POPA C SECANU V | 1996 | Mater Sci Forum1996，，： | 1 |
| 10 | Patented biomarker pan- els in early detection of cancer显示文摘 | Neagu M Constantin C Tanase C | 2011 | Recent Patents on Biomark- ers2011，1，1： | 1 |
| 11 | High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients显示文摘BACKGROUND Gastric cancer(GC)remains an aggressive malignancy with a high rate of mortality,being the third leading cause of cancer-related death.More than one million newly diagnosed cases and 782685 deaths due to GC were reported in 2018.GC is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these patients.The discovery of new biomarkers useful in the early diagnosis of GC is mandatory.AIM To evaluate the potential of COL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.METHODS Plasma and tissue obtained from 49 patients with gastric adenocarcinoma have been used in exploring the expression of COL10A1.Real-time PCR and western blot techniques were used to evaluate COL10A1 level in gastric tumor tissue compared to normal adjacent tissue.The circulating level of COL10A1 was also evaluated by ELISA in plasma of gastric adenocarcinoma patients.Survival analysis was made in order to evaluate the potential of COL10A1 as a biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.RESULTS Our results showed a significant increase in COL10A1 gene expression and protein levels in gastric tumor tissue compared to adjacent normal tissue(P<0.05).COL10A1 seems to show an elevated expression from the beginning of carcinogenesis,in the early stages,and its increased level remains elevated during cancer progression.A significant increase of COL10A1 plasma level in gastric adenocarcinoma patients was also identified.Moreover,increased COL10A1 plasma level was associated with poor survival of the patients.Plasma COL10A1 performed a diagnostic value in GC with area under the receiver operating characteristic curve(AUC)of 0.9171(P=0.0002),sensitivity of 87.76%,and specificity of 100.0%.Furthermore,this study demonstrated the potential role of plasma COL10A1 in the early detection of GC,as in the early stage,we obtained an AUC of 0.8789(P=0.0030),sensitivity of 81.25%,and specificity of 100.0%.CONCLUSION Circulating expression level of COL10A1 is significantly increased in gastric adenocarcinoma patients being associated with poor survival and is a potential biomarker for early detection of GC. | Laura Necula Lilia Matei Denisa Dragu Ioana Pitica Ana Iulia Neagu Coralia Bleotu Simona Dima Irinel Popescu Carmen C Diaconu Mihaela Chivu-Economescu | 2020 | World Journal of Gastroenterology2020，26，22： | 1 |
| 12 | Essential metals - case study on iron显示文摘 | Gurzau E S Neagu C Curzau A E | 2003 | Ecotoxicology and Environmental Safety2003，56，： | 1 |
| 13 | Anti-Mullerian hormon-aprognostic marker for metformin therapy efficiency in the treatment of women with infertility and polycystic ovary syndrome显示文摘 | Neagu M Cristescu C | 2012 | J Med Life2012，5，： | 1 |
| 14 | Dielectric spectra of natural cork and derivatives显示文摘 | LANCA M C BRANDT M NEAGU E R etal | 2010 | Journal of Non Crystalline Solids2010，356，1117： | 1 |
| 15 | Immune parameters in the prognosis and therapy monitoring of cutaneous melanoma patients: experience, role, and limitations 显示文摘 | Neagu M Constantin C Zurac S | 2013 | BioMed Research International2013，2013，10： | 1 |
| 16 | Ni-Ag thin films as strain-sensitive materials for piezoresisitive sensors显示文摘 | CHIRIAC H URSE M RUSU F HISON C NEAGU M | 1999 | Sensors and Autuators1999，76，13： | 1 |
| 17 | Anti-Muilerian hormone: a prognostic marker for metformin therapy efficiency in the treatment of women with infertility and polycystic ovary syndrome显示文摘 | Neagu M Cristescu C | 2012 | J Med Life2012，5，4： | 1 |
| 18 | Charge injection/extraction at a metal-dielectric interface:experimental validation显示文摘 | Neagu E R Dias C | 2009 | IEEE Electrical Insulation Magazine2009，25，1： | 1 |
| 19 | Postoperative pain management in elderly patients显示文摘 | Neagu S Tudor C | 2007 | Rev Med Chir Soc Med Nat Iasi2007，111，1： | 1 |
| 20 | Influence of wood-fibre hygroexpansion on the dimensional instability of fibre mats and composites 显示文摘 | Neagu R C Gamstedt E K Lindstrom M | 2005 | Composites Part A: Applied Science and Manufacturing2005，36，6： | 1 |
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