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	题名	作者	年代	出处	被引量
1	Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages显示文摘The nucleotide-binding domain,leucine-rich-repeat containing family,pyrin domain-containing 3(NLRP3)inflammasome is essential in inflammation and inflammatory disorders.Phosphorylation at various sites on NLRP3 differentially regulates inflammasome activation.The Ser725 phosphorylation site on NLRP3 is depicted in multiple inflammasome activation scenarios,but the importance and regulation of this site has not been clarified.The present study revealed that the phosphorylation of Ser725 was an essential step for the priming of the NLRP3 inflammasome in macrophages.We also showed that Ser725 was directly phosphorylated by misshapen(Msn)/NIK-related kinase 1(MINK1),depending on the direct interaction between MINK1 and the NLRP3 LRR domain.MINK1 deficiency reduced NLRP3 activation and suppressed inflammatory responses in mouse models of acute sepsis and peritonitis.Reactive oxygen species(ROS)upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.Eliminating ROS suppressed NLRP3 activation and reduced sepsis and peritonitis symptoms in a MINK1-dependent manner.Altogether,our study reveals a direct regulation of the NLRP3 inflammasome by Msn family kinase MINK1 and suggests that modulation of MINK1 activity is a potential intervention strategy for inflammasomerelated diseases.	Kaixiang Zhu Xuexiao Jin Zhexu Chi Sheng Chen Songquan Wu Richard D.Sloan Xuai Lin Dante Neculai Di Wang Hu Hu Linrong Lu	2021	Cellular & Molecular Immunology2021，18，10：	2
2	Comparison of Fenton and sono-fenton bisphenol A degradation 显示文摘	Ioan I Wilson S Lundanes E Neculai A	2007	Journal of Hazardous Materials2007，142，12：	1
3	Structure of LIMP- 2 provides functional insights with implications for SR-BI and CD36 显示文摘	Neculai D Sehwake M Ravichandran hi	2013	Nature2013，504，7478：	1
4	Partial purifica-tion and characterization of three ginsenoside-metabolizingP-glucosidases from Pythium irregular 显示文摘	Neculai M A Ivanov D Bernads M A	2009	Phytochemit-ry2009，70，1718：	1
5	Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing显示文摘	Lee K.P.K Dey M Neculai D Cao C Dever T.E and Sicheri F		0，，：	1
6	A Dai-Yuan conditions for unconstrained optimization显示文摘	NECULAI ANDREI	2008	Applied Mathematics letters2008，21，：	1
7	Structure of the dual enzyme IER1 reveals the basis for catalysis and regulation in nonconvertinal RNA splicing显示文摘	Lee KP Dey M Neculai D	2008	Cell2008，132，1：	1
8	Accelerated Scaled Memoryless BFGS Pre conditioned Conjugate Gradient Algorithm for Unconstrained Optimization显示文摘	Neculai Andrei	2010	European Journal of Operational Research2010，204，3：	1
9	Comparison of fenton and sono-Fenton bisphenol A degradation显示文摘	IOAN I WILSON S LUNDANES E NECULAI A	2007	J Hazard Mater2007，，142：	1
10	Another hybrid conjugate gradient algorithm for unconstrained optimization 显示文摘	Andrei Neculai	2008	Numerical Algorithms2008，47，：	1
11	Accelerated hybrid conjugate gradient algorithm with modified secant condition for un-constrained optimi- zation 显示文摘	Andrei Neculai	2010	Numer Algor2010，54，1：	1
12	Partial purification and characterization of three ginsenoside-metabolizing 13-glucosidases from Pythium irregulare显示文摘	Neculai M A Ivanov D Bernards M A	2009	Phytoehemistry2009，70，：	1
13	An unconstrained optimization test functions collection 显示文摘	Neculai Andrei	2008	Advanced modeling and optimization2008，10，1：	1
14	Synthesis and structure of monomeric and solcentfree LPrX2 compounds supported by a new β-diketiminato ligand 显示文摘	Dante Neculai Herbert W Roesky Ana Mirela Neculai	2002	Journal of Organometallic Chemistry2002，64，：	1
15	A Dai-Yuan conjugate gradient algorithm with sufficient descent and conjugacy conditions for unconstrained optimization显示文摘	NECULAI A	2008	Applied Mathematics Letters2008，21，：	1
16	Scavenger receptors in homeostasis and immunity 显示文摘	Canton J Neculai D Grinstein S	2013	Nat Rev Immunol2013，13，9：	1
17	Scavenger receptors in homeostasis and immunity显示文摘	CantonJ Neculai D Grinstein S	2013	Nat Rev Imrnunol2013，13，9：	1
18	Synthesis and structure of monomeric and solvent-free LPrX 2 compounds supported by a new β-diketiminato ligand [L=Et 2 NCH 2 CH 2 NC(Me)CHC(Me)NCH 2 CH 2 NEt 2 , X=Cl, Br, BH 4 ]显示文摘	Dante Neculai Herbert W. Roesky Ana Mirela Neculai J?rg Magull Hans-Georg Schmidt Mathias Noltemeyer	2002	Journal of Organometallic Chemistry2002，，：	1
19	A Dai--Yuan conjugate gradient algorithm with sufficient descent and conjugacy conditions for unconstrained optimization显示文摘	Neculai Andrei	2008	Applied Mathematics Letter2008，，21：	1
20	Structure of the dual enzyme Irel reveals the basis for catalysis and regulation in nonconventional RNA splicing显示文摘	LEE K P DEY M NECULAI D	2008	Cell2008，132，1：	1

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