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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | Cytomorphologic study of Hashimoto/s thyroiditis and its serologic correlation: a study of 150 cases显示文摘 | Singh N Kumar S Negi VS | 2009 | Aeta2009，53，5： | 1 |
| 3 | Effect of microwave cooking on the starch and protein digestibility of some newly released moth bean ( Phaseolus aconitifolius Jacq ) cultivars 显示文摘 | Negi A Boora P Khetarpaul N | 2001 | Journal of Food Composition and Analysis2001，14，： | 1 |
| 4 | The effect of tocopherylphos- phates on atherosclerosis progression in rabbits fed with a higheholesterol diet显示文摘 | Negis Y Aytan N Ozer N | 2006 | Arch Physiol Biochem2006，，450： | 1 |
| 5 | Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclervsis:role of vitamin E显示文摘 | Kartal ON Negis Y Aytan N | 2003 | Biofactors2003，19，122： | 1 |
| 6 | Ethnic identity,self - esteem, and ethnocentrism : a study ofsocial identity versus mul- ticultural theory of development 显示文摘 | Negy C Shreve T L Jensen B Uddin N | 2003 | Cultural Diversity and Eth- nic Minority Psychology2003，9，4： | 1 |
| 7 | Isolation and characterization of androgen-dependent non-histone chromosomal protein from dorsolateral prostate of rats显示文摘 | MATUO Y NISHI N NEGI T | 1982 | Biochem Biophys Res Commun1982，109，2： | 1 |
| 8 | Preparation of high performance composites based on aluminum nitride/poly(ether-ether-ketone) and their properties显示文摘 | Goyal R K Negi Y S Tiwari A N | 2005 | European Polymer Journal2005，41，9： | 1 |
| 9 | Effect of aluminum nitride on thermomechanical properties of high performance PEEK Composites:Part A显示文摘 | Goyal R K Tiwari A N Mulik U P Negi Y S | 2007 | Applied Science and Man ufacturing2007，38，2： | 1 |
| 10 | Lactation dependent expression of an mRNA splice variant with an exon for a multi- ply O-glycosylated domain of mouse milk fat globule glycoprotein MFG-E8 显示文摘 | Oshima K Aoki N Negi M | 1999 | Biochem Biophys Res Commun1999，254，3： | 1 |
| 11 | Molecular cloning and sequence analysis of cDNA Encoding Human cholesterol 7α-hydroxylase显示文摘 | Noshiro M Tanaka N Negi V | 1990 | FEBSLett1990，268，2： | 1 |
| 12 | Preparation of high performance composites based on aluminum nitride/poly (ether-etherketone) and their properties显示文摘 | Goyal R K Negi Y S Tiwari A N | 2005 | Eur Polym Journal2005，41，9： | 1 |
| 13 | Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits 显示文摘 | Ozer NK Negis Y Aytan N | 2006 | Atherosclerosis2006，184，1： | 1 |
| 14 | Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: role of vitamin E 显示文摘 | Kartal Ozer N Negis Y Aytan N | 2003 | Biofactors2003，19，12： | 1 |
| 15 | Hepatic CT perfusion measurements: a feasibility study for radiation dose reduction using new image reconstruction method 显示文摘 | NEGI N YOSHIKAWA T OHNO Y | 2012 | Eur J Radiol2012，81，11： | 1 |
| 16 | The effect of tocopheryl phos- phates on atheroscleresis progression in rabbits fed with a high cholesterol diet 显示文摘 | Negis Y Aytan N Ozer N | 2006 | Arch Physiol Biochem2006，450，1： | 1 |
| 17 | Effectiveness of estrogen in the prevention of intrauterine adhesions after hysteroscopic septal resection: A prospective, randomized study显示文摘 | Roy KK Negi N Subbaiah M | | The0，，： | 1 |
| 18 | A cross-domain role mapping and authorization framework for RBAC in grid systems 显示文摘 | GEETHAKUMARI G NEGI A SASTRY V N | 2009 | International Journal of Computer Science & Applications2009，6，1： | 1 |
| 19 | Effectiveness of estrogen in the prevention of intrauterine adhesions after hysteroscopic septal resection:a prospective,randomized study显示文摘 | Roy K K Negi N Subbaiah M | 2014 | J Obstet Gynaecol Res2014，40，4： | 1 |
| 20 | Screening interspecific hybrids of Populus (Populus ciliata×maximowiczii) using AFLP markers显示文摘 | Chauhan N Negi MS Sabharwal V 2004 | 2004 | Theor Appl Genet2004，108，： | 1 |
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