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| 1 | IgG western blot as a confirmatory test in early syphilis显示文摘 | Marangoni A Sambri V Olmo A D'Antuono A Negosanti M Cevenini R | | 0，，： | 1 |
| 2 | VAC therapy for wound man- agement in patients with contraindications to surgical treatment 显示文摘 | Negosanti L Sgarzani R Nejad P | 2012 | Dermatol Ther2012，25，3： | 1 |
| 3 | Patient satisfaction and quality of life in DIEAP flap versus implant breast reconstruction 显示文摘 | Sgarzani R Negosanti L Morselli PG | 2015 | Surg Res Pract2015，2015，40： | 1 |
| 4 | Clinical evidences, personal experiences, recent applications显示文摘Management of difficult wounds can be a complex,challenging and expensive task,especially for wounds showing a slow healing process.Topical negative pressure(TNP)therapy has greatly improved difficult wounds treatment.It allows to treat patient on an outpatient management,to reduce the complication rate with shorter hospital stay,to avoid frequent dressings with expensive advanced materials and allow a lower commitment of health professionals.Vacuum Assisted Closure(VAC)system is a therapeutic device based on the administration of a controlled TNP introduced by Morykwas and Argenta in 1997.It is indicated in different kinds of wound,but clinical evidences are present only for few of them.In this work we summarize indications and recommendations for VAC therapy and we analyze the actual better choice of treatment based on evidences and personal experience in order to stimulate further studies.Finally we introduce recent applications of VAC system such as Prevena,VAC Instill and VAC Via Prevena is a system based on TNP indicated in the management of closed wounds that present risk factors for dehiscence.VAC Instill is a system that allows to associate TNP and topical administration of solutions,such as antibiotics or disinfectants,to treat specific type of wounds.VAC Via is a device based on TNP,characterized by little dimen-sion and a preset system that allow the treatment of little wounds for 7 d,with no impairment for the patient.The aim of our paper is to describe a report of VAC therapy use in order to stimulate further studies and to define the level of evidence of VAC therapy. | Luca Negosanti Valentina Pinto Rossella Sgarzani | 2012 | World Journal of Dermatology2012，1，3： | 0 |
| 5 | Photodynamic therapy with topical aminolevulinic acid显示文摘Photodynamic therapy(PDT) is a relatively new therapy in dermatology that uses the topical application of a porphyrin derivative to selectively destroy a cutaneous target. The action is implemented by the application of a specific light frequency. The ability of porphyrin to selectively target tumor tissue has been known since the 1960 s. In the late 1970 s, the underlying mechanism was defined, and Dougherty's discovery of the first chromophore led to the production and commercialization of Photofrin. Many other chromophores that can act as photosensitizers have been studied since then, with aminolevulinic acid currently the most commonly used chromophore in clinical practice. PDT is simple, minimally invasive and can be administered on an outpatient basis. The efficacy of PDT has been proven for actinic keratosis, Bowen's disease and basal cell carcinoma; another of its well-known applications is the treatment of photoaging. Indications for its use are continuously increasing, and promising results are reported for various skin diseases. In this paper we report the mechanism of action of PDT with aminolevulinic acid, the literature concerning the most common diseases treated with PDT and the subsequent level of evidence. | Luca Negosanti Valentina Pinto Rossella Sgarzani Francesca Negosanti Guido Zannetti Riccardo Cipriani | 2014 | World Journal of Dermatology2014，3，2： | 0 |
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