|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Echocardiography in clinical prac- tice : the burden of arterial hypertension 显示文摘 | Cuspid C Negri F Giudici V | 2010 | J Hum Hypertens2010，24，6： | 1 |
| 3 | Echocardiography in clinical practice: the burden of medal hypertension显示文摘 | Cuspid C Negri F Giudici V | 2010 | J Hum Hypertens2010，24，3： | 1 |
| 4 | Echocardiography in clinical prac- tice : the burden of arterial hypertension 显示文摘 | Cuspid C Negri F Giudici V | 2010 | J Hum Hypertens2010，24，3： | 1 |
| 5 | Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies 显示文摘 | Negri E Tzonou A Beral V et a1 | 1999 | Inter J Cancer1999，80，6： | 1 |
| 6 | Risk indicators of organic diseases inuninvestigated dyspepsia: a one - week survey in 246 Italian endoscopyunits 显示文摘 | Stanghellini V Anti M Porro GB Corinaldesi R Gasbarrini G Giacosa A Fiocca R LaVecchia C Maconi G Negri E | 1999 | Eur J Gas- troenterol Hepatol1999，11，： | 1 |
| 7 | Slow-growth storage of single node shoots of apple genotypes显示文摘 | Negri V Tosti N Standardi A | 2000 | Plant Cell Tissue Organ Cult2000，62，： | 1 |
| 8 | Efficiency of three PCR-based markers in assessing genetic variation among cowpea (Vigna un- guiculata subsp, unguiculata) landraces显示文摘 | Tosti N Negri V | 2002 | Genome2002，45，2： | 1 |
| 9 | Effect of selection and temperature stress on the production of 2n gametes in Lotus tenuis显示文摘 | Negri V Lemmi G | 1998 | Plant Breeding1998，117，4： | 1 |
| 10 | Comparison of HER2 status in primary and paired metastatic sites of gastric earci- noma显示文摘 | Bozzetti C Negri F V Lagrasta C A | 2011 | Br J Cancer2011，104，9： | 1 |
| 11 | Hormonal therapy for menopause and ovarian cancer in a collaborative re-analysis of European studies 显示文摘 | Tzonou A Beral V | 1999 | Int J Cancer1999，80，6： | 1 |
| 12 | On-going on-farm microevolutionary processes in neighbouring cowpea landraces revealed by molecular markers 显示文摘 | Tosti N Negri V | 2005 | Theoretical and Applied Genetics2005，110，： | 1 |
| 13 | Improving cardiovascular risk stratification in essential hypertensive patients by indexing left ventricuIar mass to height2' 7 显示文摘 | Cuspidi C Giudici V Negri F | 2009 | J Hypertens2009，27，12： | 1 |
| 14 | p16INK4a is a useful marker for the diagnosis of adenocarcin of the cervix uteri and its precursors: an immunohistochemical study with immunocy to chernical correlations显示文摘 | Negri G Egarter V E Kasal A | 2003 | AM J Sury Pathol2003，27，2： | 1 |
| 15 | Thymidylate synthase,topoisomerase-1 and microsatellite instability:relationship with outcome in mucinous colorectal cancer treated with fluorouracil显示文摘 | Negri F V Azzoni C Bottarelli L | 2013 | Anticancer Res2013，33，10： | 1 |
| 16 | Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury 显示文摘 | Santos F B Nagato L K Boechem N M Negri E M Guimarhes A Capelozzi V L | 2006 | J Appl Physiol2006，100，： | 1 |
| 17 | Phaseolus genetic diversity maintained on-farm in central Italy 显示文摘 | Negri V Tosti N | 2002 | Genetic resources and crop evolution2002，49，5： | 1 |
| 18 | Anti-tumor effects of the proteasome inhibitor bortezomib in medullary and anaplastic thyroid carcinoma cells in vitro 显示文摘 | Mitsiades CS McMillin D Kotoula V Poulaki V McMullan C Negri J | 2006 | J Clin Endocrinol Metab2006，18，3： | 1 |
| 19 | Biochemical features of mtDNA T14484C (ND6/M64V) point mutation associated with Leber' s hereditary optic neuropathy显示文摘 | Carelli V Ghelli A Bucchi b Montagan P De Negri A Leuzzi V | | 0，，03： | 1 |
| 20 | Nocturnal nondipping and left ventricular hypertrophy in hypertension: an updated review显示文摘 | Cuspidi C Giudici V Negri F | 2010 | Expert Rev Cardiovasc Ther2010，8，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员