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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Predictors of outcome following hip fracture. Admission time predicts length of stay and in-hospital mortality显示文摘 | John E Clague Elaine Craddock Glynn Andrew Michael A Horan Neil Pendleton | 2002 | Injury2002，，1： | 2 |
| 4 | N-acyl homoserine lactone binding to the CarR receptor determines quorumsensing specificity in Erwinia 显示文摘 | Martin W Daniel E T Neil A | 2000 | EMBO J2000，1999，4： | 1 |
| 5 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotroph Appl显示文摘 | ROBERTSON L A VAN NEIL E W J TORREMANS R A M | 1988 | Environ Mcrobiol1988，54，11： | 1 |
| 6 | Effects of microbial activity on theδ18O of dissolved inorganic phosphate and textural features of synthetic apatite显示文摘 | Blake R E O'Neil J R Garacia G A | 1998 | American Mineralogist1998，83，11122： | 1 |
| 7 | Replacing 100%fruit juice with whole fruit results in a trade-off of only two nutrients in the diets of children显示文摘 | T A Nicklas C E O'Neil V L Fulgoni | 2014 | Journal of the Academy of Nutrition and dietetics2014，114，9： | 1 |
| 8 | Constructive sludge manage- ment: biobrick显示文摘 | James E Alleman Neil A Berman | 1984 | Journal of Environmental Engineering1984，110，2： | 1 |
| 9 | Biogeochemical cycling of phosphorus:insights from oxygen isotope effects of phosphoenzymes显示文摘 | Blake R E O'Neil J R Surkov A | 2005 | American Journal of Science2005，305，68： | 1 |
| 10 | Prevalence of ischemic nephropathy in patients with renal insufficiency显示文摘 | O'Neil E A Hansen K J Canzanello V J | 1992 | Am Surg1992，58，： | 1 |
| 11 | Gastrointestinal symptoms in patients with end-stage renal disease undergoing treatment by hemodialysis or peritoneal dialysis 显示文摘 | Cano A E Neil A K Kang J Y Barnabas A Eastwood J B Nelson S R | 2007 | Am J Gastroenterol2007，102，： | 1 |
| 12 | Type of Vascular Access and Survival among Incident Hemodialysis Patients: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study显示文摘 | Brad C A Joseph A E Neil R P | 2005 | J Am Soc Nephrol2005，16，5： | 1 |
| 13 | Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47) 显示文摘 | Adler A I Neil H A Manley S E | 1999 | Am Heart J1999，138，51： | 1 |
| 14 | Simultaneous Nitrification and Denitrification in Aerobic Chemostat Cultures Cultures of Thiosphaera Pantotroph显示文摘 | ROBERTSON L A VAN NEIL E W J TORREMANS R A M | 1988 | Appl Environ Mcrobiol1988，54，11： | 1 |
| 15 | Geodynamics of the Tarim Basin and the Tian Shan in central Asia显示文摘 | E A Neil G Houseman | 1997 | tectonics1997，16，4： | 1 |
| 16 | Simultaneous nitrification and denitrification aerobic chemostat cultures of thiosphaera pantotropha显示文摘 | Robertsno L A Van Neil E W J | 1988 | Applied Environmental Microbiology1988，54，1： | 1 |
| 17 | Cytokine therap-y:a natural alternative for disease control显示文摘 | Lowental J W O'Neil T E David A | 1999 | Vet Immunol Immunopathol1999，72，： | 1 |
| 18 | Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial显示文摘 | Hagop M Kantarjian Andreas Hochhaus Giuseppe Saglio Carmino De Souza Ian W Flinn Leif Stenke Yeow-Tee Goh Gianantonio Rosti Hirohisa Nakamae Neil J Gallagher Albert Hoenekopp Rick E Blakesley Richard A Larson Timothy P Hughes | 2011 | Lancet Oncology2011，，9： | 1 |
| 19 | Geodynamics of the Tarim basin and Tianshan in central Asian显示文摘 | Neil E A Houseman G A | 1997 | Tectonics1997，16，4： | 1 |
| 20 | The effect of an additional phosphite stabilizer on the properties ef radiation cross-linked vitamin E blends of UHMWPE显示文摘 | Oral E Neils A Yabannavar P | 2014 | Journal ef Orthopaedic Research2014，32，6： | 1 |
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