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| 1 | Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma显示文摘AIM: To characterise expression of known E-cadherin repressors; Snail, Slug and Twist in the development of esophageal adenocarcinoma. METHODS: E-cadherin, Slug, Snail and Twist mRNA expression in Barrett's metaplasia and esophageal adenocarcinoma specimens was examined by real-time reverse transcription-polymerase chain reaction (RT-PCR). Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein levels. The effect of Slug on epithelial mesenchymal transition (EMT) markers was examined by transfection of Slug into an adenocarcinoma line OE33.RESULTS: Cellular localisation of Slug in Barrett's metaplasia was largely cytoplasmic whilst in adenocarcinoma it was nuclear. Semi-quantitative analysis indicated that Slug was more abundant in adenocarcinoma compared to matched Barrett's metaplastic specimens. Snail and Twist were expressed in adenocarcinoma but were cytoplasmic in location and not induced compared to Barrett's mucosa. These observations were supported by mRNA studies where only Slug mRNA was shown to be over-expressed in adenocarcinoma and inversely correlated to E-cadherin expression. Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin.CONCLUSION: Progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing. | Paras Jethwa Mushal Naqvi Robert G Hardy Neil A Hotchin Sally Roberts Robert Spychal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，7： | 24 |
| 2 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Biorefining of softwoods using ethanol organosolv pulping:Preliminary evaluation of process streams for manufacture of fuel-grade ethanol and co-products 显示文摘 | PAN Xue-jun CLAUDIO A NEIL G | 2005 | Biotechnology and Bioengineering2005，90，4： | 1 |
| 5 | Effects of microbial activity on theδ18O of dissolved inorganic phosphate and textural features of synthetic apatite显示文摘 | Blake R E O'Neil J R Garacia G A | 1998 | American Mineralogist1998，83，11122： | 1 |
| 6 | Nanoindentation assessment of aluminium metallisation; the effect of creep and pile-up显示文摘 | Soare S Bull S J O'Neil A G | 2004 | Surface and Coatings Technology2004，，177178： | 1 |
| 7 | A Tutorial on Particle Filters for Online Nonlinear/Non-Gaussian Bayesian Tracking显示文摘 | Sanjeev A M Simon M Neil G | 2002 | IEEE Trans on Signal Processing2002，50，2： | 1 |
| 8 | A tutorial on particle filters for on-line non-linear/non-Gaussian Bayesian traeking 显示文摘 | Sanjeev A Simon M Neil G | 2002 | IEEE Transactions on Signal Processing2002，50，2： | 1 |
| 9 | Fatty acid synthase effect on bovine adipose fat and milk fat 显示文摘 | Chris A M Neil G C Belinda C G | 2007 | Mammalian Ge- nome2007，18，1： | 1 |
| 10 | Geodynamics of the Tarim Basin and the Tian Shan in central Asia显示文摘 | E A Neil G Houseman | 1997 | tectonics1997，16，4： | 1 |
| 11 | Tracing the density impulse in rural settlement systems: A quantitative analysis of the factors underlying rural population density across south-eastem Australia, 1981 - 2001 显示文摘 | Neil M A Peter J S Trevor G | 2005 | Population and Environment2005，27，2： | 1 |
| 12 | Calcium signaling in cell volume regulation显示文摘 | McCarty N A O'Neil R G | 1992 | Physiological Reviews1992，72，： | 1 |
| 13 | Geodynamics of the Tarim basin and Tianshan in central Asian显示文摘 | Neil E A Houseman G A | 1997 | Tectonics1997，16，4： | 1 |
| 14 | The comet assay to determine the mode of cell death for the ultrasonic de- livery of doxorubicin to human leukemia (HL260 Cells) from Pluronic P105 cells 显示文摘 | Hussein G A O'Neil K L Pitt W G | 2005 | Technology in Cancer Re- search Treat2005，4，6： | 1 |
| 15 | Modeling the impact of patient and lesion characteristics on the cost-effectiveness of drug-eluting stents 显示文摘 | GREENBER G D BAKHAI A NEIL N | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 16 | A Tutorial on particle filters for online nonlinear/non gaussian bayesian tracking显示文摘 | SANJEEV A M SIMON M NEIL G | 2002 | IEEE Transactions on Signal Processing2002，50，2： | 1 |
| 17 | Long-Term Wireless Structual Health Monitoring of the Ferriby Road Bridge显示文摘 | Neil A Hoult Paul R A Fidler Peter G Hill | 2010 | Journal of Bridge Engineering2010，15，2： | 1 |
| 18 | Multidimensional computerized adaptive testing of the EORTC QLQ-C30:Basic developments and evaluations显示文摘 | Morten P Mogens G Neil A | | 0，，03： | 1 |
| 19 | Multidimensional computerized adaptive testing of the EORTC QLQ-C30:Basic developments and evaluations显示文摘 | Morten P Mogens G Neil A | | 0，，03： | 1 |
| 20 | A tutorial on particle filters for on-line no-linear/non-Gaussian Bayesian tracking显示文摘 | Sanjeev A Simon M Neil G | 2002 | IEEE Trans on Signal Processing2002，50，2： | 1 |
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