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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | The value of the world’s ecosystemservices and natural capita1显示文摘 | Costanza R Arge R Groot R Farberk S Grasso M HannonB Limburg K Naeem S O’Neil R Paruelo J Raskin R Suttonkk P &Belt M | 1997 | Nature1997，387，： | 1 |
| 4 | Investigating equity sensitivity as a moderator of relations between self-efficacy and workplace attitudes 显示文摘 | O'Neil B S Mone M A | 1998 | Journal of Applied Psychology1998，83，5： | 1 |
| 5 | Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin 显示文摘 | Jouvenet N Neil S J Zhadina M | 2009 | J Virol2009，83，4： | 1 |
| 6 | Structural basis of a phololropinlight switch显示文摘 | Harper S M Neil L C Gardner K H | 2003 | Science2003，301，5639： | 1 |
| 7 | Inflammatory disorders and atherosclerosis:new therapeutic approaches显示文摘 | Charakida M O' Neil F Masi S | | 0，，37： | 1 |
| 8 | Visualization of the Brassica Self-Incompatibility S-locus on Identified Oilseed Rape Chromosomes显示文摘 | Kamisugi Y Nakayama S O'Neil C M | 1998 | Plant Molecular Biology1998，38，： | 1 |
| 9 | Requirement of borate cross-linking of cell wall rhamnogalacturonanⅡfor Arabidopsis growth 显示文摘 | O'Neil M A Eberhard S Albersheim P | 2001 | Science2001，294，5543： | 1 |
| 10 | Using bayesian belief networks to predict the reliability of military vehicles 显示文摘 | Neil M Fenton N Forey S | 2001 | Computing and Control Engineering Journal2001，12，1： | 1 |
| 11 | Gene expression: Total silencing by intron spliced hairpin RNAs显示文摘 | Neil A S Surinder P S Wang M B | 2000 | Nature2000，407，： | 1 |
| 12 | Under- standing the effects of sand and dust accumulation on pho- tovoltaic modules 显示文摘 | NEIL S B ROBERT S M CHARLSLEE C | 2012 | Renewable Energy2012，，48： | 1 |
| 13 | Web-based re- search: Methodological variables' effects on dropout and sample characteristics 显示文摘 | O' neil K M Penrod S D Bornstein B H | 2003 | Behavior Research Methods Instruments & Computers2003，35，2： | 1 |
| 14 | Using Bayesian belief networks to predict the reliability of military vehicles显示文摘 | Neil M Fenton N Forey S | 2001 | Computing and Control Engineering Journal2001，12，1： | 1 |
| 15 | Bacterial commu- nity structure and function change in association with coloni zer plants during early primary succession in a glacier forefield 显示文摘 | Knelman J E Legg T M O'Neil S P etal | 2012 | Soil Biology and Biochemistry2012，46，： | 1 |
| 16 | Postoperative analgesic effects of celecoxb or rofecoxib after spinal Iusion surgery显示文摘 | Scott S Reuben M D Neil R C | 2000 | Anelsth Analg2000，9，： | 1 |
| 17 | The DNA binding activity of TAL-1 is not required toinduce leukemia/lymphoma in mice显示文摘 | Neil J Billa M Oidemus S | 2001 | Oncogene2001，20，29： | 1 |
| 18 | Tracing the density impulse in rural settlement systems: A quantitative analysis of the factors underlying rural population density across south-eastem Australia, 1981 - 2001 显示文摘 | Neil M A Peter J S Trevor G | 2005 | Population and Environment2005，27，2： | 1 |
| 19 | An Fc receptor structurally related to MHC class I antigens显示文摘 | Neil E S Keith E M | 1989 | Nature1989，337，： | 1 |
| 20 | Stable expression of a functional homo-oligomeric drosophila GABA receptor in a drosophila cell line显示文摘 | NEIL S M STEVEN D B DAVID B S | 1994 | Proc Roy Soc Lond B: Biolog Sci1994，258，1353： | 1 |
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