|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of necrotizing pancreatitis显示文摘Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding. | John Slavin Paula Ghaneh Robert Sutton Mark Hartley Peter Rowlands Conall Garvey Mark Hughes John Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 21 |
| 2 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005，，1： | 9 |
| 3 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005，，1： | 6 |
| 4 | Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression显示文摘AIM: To establish stable tetracycline-inducible pancreatic cancer cell lines. METHODS: Suit-2, MiaPaca-2, and Panc-1 cells were transfected with a second generation reverse tetracycline-controlled transactivator protein (rtTA2S-M2), under the control of either a cytomegalovirus (CMV) or a chicken β-actin promoter, and the resulting clones were characterised.RESULTS: Use of the chicken (β-actin) promoter proved superior for both the production and maintenance of doxycycline-inducible cell lines. The system proved versatile, enabling transient inducible expression of a variety of genes, including GST-P, CYP2E1, S100A6, and the actin capping protein, CapG. To determine the physiological utility of this system in pancreatic cancer cells, stable inducible CapG expressors were established. Overexpressed CapG was localised to the cytoplasm and the nuclear membrane, but was not observed in the nucleus. High CapG levels were associated with enhanced motility, but not with changes to the cell cycle, or cellular proliferation. In CapG-overexpressing cells, the levels and phosphorylation status of other actin-moduating proteins (Cofilin and Ezrin/Radixin) were not altered. However, preliminary analyses suggest that the levels of other cellular proteins, such as ornithine aminotransferase and enolase, are altered upon CapG induction. CONCLUSION: We have generated pancreatic-cancer derived cell lines in which gene expression is fully controllable. | Sarah Tonack Sabina Patel Mehdi Jalali Taoufik Nedjadi Rosalind E Jenkins Christopher Goldring John Neoptolemos Eithne Costello | 2011 | World Journal of Gastroenterology2011，17，15： | 4 |
| 5 | Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)显示文摘 | Moritz N. Wente Claudio Bassi Christos Dervenis Abe Fingerhut Dirk J. Gouma Jakob R. Izbicki John P. Neoptolemos Robert T. Padbury Michael G. Sarr L. William Traverso Charles J. Yeo Markus W. Büchler | 2007 | Surgery2007，，5： | 4 |
| 6 | Adjuvant therapy in pancreatic cancer显示文摘The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic csncer, leading to a drsmatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone.The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients. | Paula Ghaneh John Slavin Robert Sutton Mark Hartley John P Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 3 |
| 7 | Postpancreatectomy hemorrhage (PPH)–An International Study Group of Pancreatic Surgery (ISGPS) definition显示文摘 | Moritz N. Wente Johannes A. Veit Claudio Bassi Christos Dervenis Abe Fingerhut Dirk J. Gouma Jakob R. Izbicki John P. Neoptolemos Robert T. Padbury Michael G. Sarr Charles J. Yeo Markus W. Büchler | 2007 | Surgery2007，，1： | 2 |
| 8 | Early and late complications after pancreatic necrosectomy显示文摘 | S. Connor N. Alexakis M.G.T. Raraty P. Ghaneh J. Evans M. Hughes C.J. Garvey R. Sutton J.P. Neoptolemos | 2005 | Surgery2005，，5： | 2 |
| 9 | Acute pancreatitis and organ failure: Pathophysiology, natural history, and management strategies显示文摘 | Michael G. T. Raraty FRCS PhD Saxon Connor FRACS David N. Criddle PhD Robert Sutton DPhil FRCS John P. Neoptolemos MA MD FRCS | 2004 | Current Gastroenterology Reports2004，，2： | 2 |
| 10 | Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells显示文摘 | David M. Booth John A. Murphy Rajarshi Mukherjee Muhammad Awais John P. Neoptolemos Oleg V. Gerasimenko Alexei V. Tepikin Ole H. Petersen Robert Sutton David N. Criddle | 2011 | Gastroenterology2011，，7： | 2 |
| 11 | Low mortality following resection for pancreatic and periampullary tumours in 1026 patients:UK survey of specialist pancreatic units显示文摘 | Neoptolemos JP Russel RC Bramhall S | 1997 | Br J Surg1997，84，： | 2 |
| 12 | Minimal Access Retroperitoneal Pancreatic Necrosectomy: Improvement in Morbidity and Mortality With a Less Invasive Approach显示文摘 | Michael G. T. Raraty Christopher M. Halloran Susanna Dodd Paula Ghaneh Saxon Connor Jonathan Evans Robert Sutton John P. Neoptolemos | 2010 | Annals of Surgery2010，，5： | 2 |
| 13 | Endoscopic sphincterotomy in acute gallstone pancreatitis显示文摘 | Neoptolemos JP | 1993 | Br J Surg1993，80，5： | 1 |
| 14 | Early prediction of severity in acute pancreafitis by urinary trypsinogen activation peptide: a multicentre study显示文摘 | Neoptolemos Jp Kemppainen EA Mayer JM | 2000 | Lancet2000，355，3： | 1 |
| 15 | Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones显示文摘 | Neoptolemos JP Carr-Locke DL London NJ | 1988 | Lancet1988，2，8618： | 1 |
| 16 | Low mortality following resection for pancreatic and periampuUary turnouts in 1026 patients: UK survey of pancreatic specialist units显示文摘 | Neoptolemos JP Russell RCG Bramhall S | 1997 | Br J Surg1997，84，： | 1 |
| 17 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005，，1： | 1 |
| 18 | Controlled trial of urgent endoscopic retrograde eholangiopancreatography and endoscopic sphineterotomy versus conservative treatment for acute panereatitis due to gallstones 显示文摘 | Neoptolemos JP Cart-Locke DL London NJ | 1988 | Lancet1988，2，8618： | 1 |
| 19 | Pancre- atic cancer bENT1 expression and survival from gem- citabine in patients from the ESPAC-3 trial显示文摘 | GreenhalfW Ghaneh P Neoptolemos JP | 2014 | JNatl Can- cer Inst2014，106，1： | 1 |
| 20 | Inflammatory mediators as therapeutic targets in acute pancreatits 显示文摘 | Bhatia M Neoptolemos JP Slavin J | 2001 | Curr Opin investing Drugs2001，2，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员