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| 1 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 2 | Aboul-Enein c,Effects of the vasoactive intestinal peptide on stress-induced mucosalulcers and modulation of methylation of histamine in gastric tissue of the rats显示文摘 | Nese Tunc el a Muzaffer Tunc el b Hassan Y | 2003 | Received I1 Farmaco2003，58，： | 1 |
| 3 | The Circuit Point of View of the Temperature Dependent Open Circuit Voltage Decay of the Solar Cell 显示文摘 | Sertap Kavasoglu A Nese Kavasoglu Sener Oktik | 2009 | Solar Energy2009，83，9： | 1 |
| 4 | Anodic bonding of silicon to silicon wafers coated with aluminum, silicon oxide,polysilicon or silicon nitride 显示文摘 | Nese M Hanneborg A | 1993 | sensors and Actuators1993，3738，： | 1 |
| 5 | Use of Phototherapy for Neonatal Hyperbilirubinemia Affects Cytokine Production and Lymphocyte Subsets显示文摘 | Kurt Abdullah Aygun A Denizmen Kurt A Nese Citak Godekmerdan Ahmet Akarsu Saadet Yilmaz Erdal | 2009 | Neonatology2009，，3： | 1 |
| 6 | Human Milk Fat Substitutes Containing Omega-3 Fatty Acids显示文摘 | NESE ? CASIMIR C A ARTEMS K | 2006 | Journal of Agricultural and Food Chemistry2006，54，37： | 1 |
| 7 | Enzymatic Production of Human Milk Fat Substitutes Containing g-Linolenic Acid: Optimiza tion of Reactions 显示文摘 | NESE S CASIMIR C A ARTEMIS K | 2005 | Joumal of the American Oil Chemists' Society2005，82，8： | 1 |
| 8 | Butyrylcholinesterase: Structure and Physiological Importance显示文摘 | Nese Cokugras A | 2003 | Turkish Journal of Biochemistry- Turk J Biochem2003，28，2： | 1 |
| 9 | Anti-Arrhenius cleavage of covalent bonds in bottlebrush macromolecules on substrate 显示文摘 | Lebedeva N V Nese A Sun F C Matyjaszewski K Sheiko S S | 2012 | Proceedings of the National Academy of Sciences of the United States of America2012，109，24： | 1 |
| 10 | 显示文摘 | Nese A Sen S Tasdelen M A | 2006 | Macromolecular Chemistry and Physics2006，207，9： | 1 |
| 11 | Enzymatic production of human milk fat substitutes containing γ-linolenic acid:optimization of reactions by response surface methodology显示文摘 | Nese S Casimir C A Artemis K | 2005 | J Am Oil Chem Soc2005，82，： | 1 |
| 12 | Enzymatic production of human milk fat substitutes containing γ-linolenic acid:optimization of reactions by response surface methodology显示文摘 | NESE S CASIMIR C A ARTEMIS K | 2005 | J Am Oil Chem Soc2005，82，： | 1 |
| 13 | Boron etch-stop in TMAH solu- tions显示文摘 | Steinsland E Nese M Hanneborg A Bernstein R W Sandmo H Kittilsland G | 1996 | Sensors and Actuators A-Physical1996，54，： | 1 |
| 14 | Anodic bonding of silicon to silicon wafers coated with aluminum, silicon oxide, polysilicon or silicon nitride显示文摘 | Nese M Hanneborg A | 1993 | Sensors & Actuators A1993，3738，： | 1 |
| 15 | pH-Responsive fluorescent molecular bottlebrushes prepared by atom transfer radical polymerization显示文摘 | Nese A Lebedeva N V Sherwood G | 2011 | Macromolecules2011，44，15： | 1 |
| 16 | Syntheis of amphiphilic poly( N-vinylpyrrolidone ) -b-poly ( vinyl acetate ) molecu- lar botdcbrushes显示文摘 | Nese A Li Y C Averick S | 2012 | ACS Macro Lett2012，1，1： | 1 |
| 17 | Effects of dietary supplementation with organic acids and Zinc bacitracin on ideal microflora,p H and performance in b roilers显示文摘 | Mujdat A Nese K Recep K | 1999 | Tr J of Veterinary and Animal Sciences1999，23，： | 1 |
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