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| 1 | Analysis of TRPA1 antagonist,A-967079,in plasma using high-performance liquid chromatography tandem mass-spectrometry显示文摘The noxious effects from exposure to toxic inhalation hazards(TIHs,such as isocyanates,chlorine,etc.)are known to be triggered by the activation of transient receptor potential ankyrin 1(TRPA1)ion channel.Antagonists of TRPA1 have shown near complete attenuation of the noxious effects from TIH exposure.One of the TRPA1 antagonists,(1E,3E)-1-(4-fluorophenyl)-2-methyl-1-pentene-3-one oxime(A-967079),has shown impressive efficacy,high selectivity,high potency,and oral bioavailability.Although a vali-dated method to quantify A-967079 in biological matrices is vital for the further development of A-967079 as a therapeutic agent,no method for its analysis from any matrix is currently available.Hence,a rapid and simple HPLC-MS/MS method was developed and validated to quantify A-967079 in rabbit plasma.The method presented here features an excellent LOD of 25 nM and a wide linear range(0.05-200μM),with good accuracy and precision(100±10.5%and<14.2%relative standard deviation,respectively).The stability of A-967079 in plasma was excellent for most of the storage conditions evaluated.The method was successfully applied to determine A-967079 from treated animals and it may facilitate the development of this TRPA1 antagonist as a therapeutic agent against the noxious effects of TIH exposure. | Obed A.Gyamfi Nesta Bortey-Sam Abigail B.Donkor Carl W.White Brian A.Logue | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 2 |
| 2 | Tracking of multidimensional TDOA for multiple sources with distributed microphone pairs显示文摘 | BRUTTI A and NESTA F | 2013 | Computer Speech & Language2013，27，3： | 1 |
| 3 | University patenting and its effects on academic research : The emerging European evidence 显示文摘 | Geuna A Nesta L | 2006 | Research Policy2006，35，6： | 1 |
| 4 | University patenting and its effects on academic research: the emerging European evidence 显示文摘 | Aldo Giuna Lionel Nesta | 2006 | Research Policy2006，，35： | 1 |
| 5 | University patenting and its effects onacademic research : the emerging European evidence 显示文摘 | GeunaA Nesta L | 2006 | Research Policy2006，，6： | 1 |
| 6 | University patenting and its effects on tcademic: research: the emerging Europe- an evidence显示文摘 | ALDO GEUNA I IONEL J J NESTA | 2006 | Re search Policy2006，，6： | 1 |
| 7 | What kind of knowledge can a firm absorb? 显示文摘 | MANGEMATIN V NESTA L | 1999 | lnt J Technol Manage1999，18，34： | 1 |
| 8 | University patenting and its effects on academic research: the emerging European evidence显示文摘 | GEUNA A NESTA L | 2006 | Research Policy2006，35，6： | 1 |
| 9 | Convolutive BSS of short mixtures by ICA recursively regularized across fi'equencies显示文摘 | NESTA F SVAIZER P OMOLOGO M | 2010 | IEEE Transactions on Audio Speech and Language Processing2010，，99： | 1 |
| 10 | Product innovation and survival in a high- teeh industry显示文摘 | Fontana R Nesta L | 2009 | Review of Industrial Organiza-tion2009，34，4： | 1 |
| 11 | University patenting and its effects on academic research:the emerging European evidence 显示文摘 | Geuna A Nesta L | 2006 | Research Policy2006，35，6： | 1 |
| 12 | University patenting and its effects on academic research: The emerging European evidence 显示文摘 | Geuna A Nesta L | 2006 | Research Policy2006，35，6： | 1 |
| 13 | Technology strategy and know- ledge dynamics:The case of biotech显示文摘 | Nesta L Dibiaggio L | 2003 | Industry and Innovation2003，10，3： | 1 |
| 14 | Coherence of the knowledge base and the firm's innovative performance:Evidence from the US pharmaceutical industry显示文摘 | Nesta L Saviotti P P | 2005 | The Joumal of Industrial Economics2005，53，1： | 1 |
| 15 | University patenting and its effects on academic research: the emerging European evidence显示文摘 | Geuna A Nesta L | 2007 | International Journal of Management Reviews2007，，9： | 1 |
| 16 | Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization显示文摘 | Serino L Nesta B Leuzzi R | 2007 | Mol Microbiol2007，64，5： | 1 |
| 17 | Financial Constraints and Firm Export Behaviour显示文摘 | Bellone F Musso P Schiavo Nesta L | 2010 | World Economy2010，33，3： | 1 |
| 18 | Schumpeterian perspectives on innovation,competition and growth显示文摘 | Cantner U Gaffard J L Nesta L | | 0，，03： | 1 |
| 19 | Substitutability and complementarity of technological knowledge and the inventive performance of semiconductor compa- nies显示文摘 | Dibiaggio L Nasiriyar M Nesta L | 2014 | Research Policy2014，43，9： | 1 |
| 20 | Knowledge and productivity in the world's largest manufacturing corporations显示文摘 | Nesta L | 2008 | Joumal of Eco- nomic Behavior & Organization2008，67，3： | 1 |
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