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| 1 | Challenging rescue of a 4 years old boy with H1N1 infection by extracorporeal membrane oxygenator: A case report显示文摘Introduction: World Health Organization announced on April 2009 a public health emergency of international concern caused by swine-origin influenza A(H1N1) virus. Acute respiratory distress syndrome(ARDS) has been reported to be the most devastating complications of this pathogen. Extracorporeal membrane oxygenator(ECMO) therapy for patients with H1N1 related ARDS has been described once all other therapeutic options have been exhausted. Here, we report the case of a child(German, male) with H1N1-associated fulminate respiratory and secondary hemodynamic deterioration who was rescued by initial emergent ECMO established through a dialysis catheter and subsequent switch to central cannulation following median sternotomy. This report highlights several important issues. First, it describes a successful use of a dialysis catheter for the establishment of a veno-venous ECMO in an emergency case by child. Second, it highlights the importance of a closely monitoring of clotting parameters during ECMOtherapy and third, if severe respiratory failure is complicated by cardiogenic shock, veno-atrial ECMO support via median sternotomy should be considered as a viable treatment option without further delay. | Nestoras Papadopoulos Sven Martens Harald Keller Ali El-Sayed Ahmad Anton Moritz Andreas Zierer | 2014 | World Journal of Clinical Cases2014，2，10： | 1 |
| 2 | Long-Term Results After Surgical Repair of Postinfarction Ventricular Septal Rupture by Infarct Exclusion Technique显示文摘 | Nestoras Papadopoulos Anton Moritz Omer Dzemali Andreas Zierer Amin Rouhollapour Hanns Ackermann Farhad Bakhtiary | 2009 | The Annals of Thoracic Surgery2009，，5： | 1 |
| 3 | A monte carlo approach for maximum power estimation based on extreme value theory显示文摘 | Nestoras E Evmorfopoulos | 2002 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems2002，21，4： | 1 |
| 4 | Selective antegrade cerebral perfusion and mild (28°C-30°C) systemic hypothermic circulatory arrest for aortic arch replacement: Results from 1002 patients显示文摘 | Andreas Zierer Ali El-Sayed Ahmad Nestoras Papadopoulos Anton Moritz Anno Diegeler Paul P. Urbanski | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，5： | 1 |
| 5 | Percutaneous coronary intervention in octogenarians:10-year experience from a primary percutaneous coronary intervention centre with off-site cardiothoracic support显示文摘OBJECTIVE To examine the trends in patient characteristics and clinical outcomes over a ten-year period and to analyse the predictors of mortality in octogenarians undergoing percutaneous coronary intervention(PCI)in our centre.METHODS A total of 782 consecutive octogenarians(aged 80 and above)were identified from a prospectively collected PCI database within our non-surgical,medium volume centre between 1st January 2007 and 31st December 2016.This represented 10.9%of all PCI procedures performed in our centre during this period.We evaluated the demographic and procedural character-istics of the cohort with respect to clinical outcomes(all-cause in-hospital and 1-year mortality,in-hospital complication rates,duration of hospital admission,coronary disease angiographic complexity and major co-morbidities).The cohort was further stratified into three chronological tertiles(January 2007 to July 2012,261 cases;August 2012 to May 2015,261 cases;June 2015 to December 2016,260 cases)to assess for differences over time.Predictors of mortality were identified through a multivariate re-gression analysis.RESULTS The number of octogenarians undergoing PCI increased nearly ten-fold over the studied period.Despite this,there were no significant differences in clinical outcomes or patient characteristics,except for the increased use of trans-radial vascular access[11.9%in first tertile vs.73.2%in third tertile(P<0.0001)].The all-cause in-hospital(5.8%vs.4.6%vs.3.8%,P=0.578)and 1-year mortality(12.4%vs.12.5%vs.14.4%,P=0.746)remained constant in all three tertiles respectively.Six independent predict-ors of mortality were identified-increasing age[HR=1.12(1.03−1.22),P=0.008],cardiogenic shock[HR=16.40(4.04-66.65),P<0.0001],severe left ventricular impairment[HR=3.52(1.69−7.33),P=0.001],peripheral vascular disease[HR=2.73(1.22−6.13),P=0.015],diabetes[HR=2.59(1.30−5.17),P=0.007]and low creatinine clearance[HR=0.98(0.96−1.00),P=0.031].CONCLUSION This contemporary observational study provides a useful insight into the real-world practice of PCI in octogen-arians. | Joanna Abramik Amardeep Dastidar Nestoras Kontogiannis Victoria North Gopendu Patri Nicholas Weight Tushar Raina George Kassimis | 2022 | Journal of Geriatric Cardiology2022，19，3： | 0 |
| 6 | Prognostic value of ΔSYNTAX% score in octogenarians undergoing percutaneous coronary intervention显示文摘OBJECTIVES To verify whether incomplete revascularisation(IR),quantified using the rSYNTAX(Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery)score andΔSYNTAX%score,could predict short-(in-hospital mortality)and long-term outcomes(12-month mortality)in octogenarians undergoing percutaneous coronary intervention(PCI).METHODS&RESULTS A retrospective analysis of 665 consecutive octogenarian patients presenting for PCI to a UK centre was performed.The baseline SYNTAX and rSYNTAX scores were assessed from angiographic images.ΔSYNTAX%score was calculated(ΔSYNTAX%=((SYNTAX-rSYNTAX)/SYNTAX)×100%))to measure the relative completeness of revascularisation.Kaplan-Meier analysis assessed survival at 12 months by tertiles of rSYNTAX andΔSYNTAX%scores.IncreasingΔSYNTAX%score was associated with reduced in-hospital mortality(P=0.017),and improved survival benefit(log rank 14.8,P=0.001)at 12 months.CONCLUSIONS Enhancing the completeness of revascularisation in octogenarians selected to undergo PCI is associated with a lower in-hospital mortality and a survival benefit at 12 months. | Joanna Abramik Nestoras Kontogiannis Roberto Scarsini Giovanni Luigi De Maria Tushar Raina Nikolaos Fragakis George Kassimis | 2023 | Journal of Geriatric Cardiology2023，20，7： | 0 |
| 7 | Inner jet kinematics and the viewing angle towards the γ-ray narrow-line Seyfert 1 galaxy 1H 0323+342显示文摘Near-Eddington accretion rates onto low-mass black holes are thought to be a prime driver of the multi-wavelength properties of the narrow-line Seyfert 1(NLS1) population of active galactic nuclei(AGNs). Orientation effects have repeatedly been considered as another important factor involved, but detailed studies have been hampered by the lack of measured viewing angles towards this type of AGN. Here we present multi-epoch, 15 GHz VLBA images(MOJAVE program) of the radio-loud and Fermi/LATdetected NLS1 galaxy 1H 0323+342. These are combined with single-dish, multi-frequency radio monitoring of the source's variability, obtained with the Effelsberg 100-m and IRAM 30-m telescopes, in the course of the F-GAMMA program. The VLBA images reveal six components with apparent speeds of^1- 7 c, and one quasi-stationary feature. Combining the obtained apparent jet speed(β_(app)) and variability Doppler factor(D_(var)) estimates together with other methods, we constrain the viewing angle θ towards1 H 0323+342 to θ≤ 4°–13°. Using literature values of βapp and D_(var), we also deduce a viewing angle of≤8°–9°towards another radio- and γ-ray-loud NLS1, namely SBS 0846+513. | Lars Fuhrmann Vassilis Karamanavis Stefanie Komossa Emmanouil Angelakis Thomas E Krichbaum Robert Schulz Annika Kreikenbohm Matthias Kadler Ioannis Myserlis Eduardo Ros Ioannis Nestoras J. Anton Zensus | 2016 | Research in Astronomy and Astrophysics2016，16，11： | 0 |
| 8 | 基于大语言模型的糖尿病管理:潜力与展望显示文摘The increasing prevalence of diabetes has become a global public health concern in the 21st century.In 2021,it was estimated that 537 million people had diabetes,and this number is projected to reach 643 million by 2030,and 783 million by 2045[1].Such a huge burden of diabetes brings great challenges in its prevention and management,including early diagnosis,timely interventions,and regular monitoring of risk factor control and complications screening.Continuous self-care support and patient empowerment can enhance clinical and psychobehavioural outcomes[2],although these require additional resources including manpower,infrastructure(hard and technology),and finances.The emergence of digital health technologies(DHTs),especially artificial intelligence(AI),may help address these obstacles and alleviate the burden of diabetes[3].Large language models(LLMs),a generative AI that can accept image and text inputs and produce text outputs,have shown promise in various aspects of medical care. | 盛斌 管洲榆 Lee-Ling Lim 江泽铧 Nestoras Mathioudakis 李佳佳 刘茹涵 包玉倩 Yong Mong Bee 王亚星 郑颖丰 Gavin Siew Wei Tan 纪宏伟 Josip Car 王海波 David C.Klonoff 李华婷 覃宇宗 黄天荫 贾伟平 | 2024 | Science Bulletin2024，69，5： | 0 |
| 9 | Steerable microcatheters for complex percutaneous coronary interventions in octogenarians: from Venture to Swift Ninja显示文摘0ctogenarians represent the fastest growing group of patients undergoing percutaneous coronary intervention(PCI),now constituting more than one in five patients treated with PCI in real-world practice.[1,2]Comparing coronary lesion characteristics of patients aged<≥80 years to those≥80 years undergoing PCI,the octogenarians have a higher prevalence of calcified and ostial lesions,tortuous coronary anatomy,multi-vessel disease and left main stem(LMS)stenosis.⑶Furthermore,they often have greater ischemic burden than their younger counterparts,suggesting an even greater benefit following revascularization. | George Kassimis Nestoras Kontogiannis Tushar Raina | 2019 | Journal of Geriatric Cardiology2019，16，1： | 0 |
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