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| 1 | In search of the Chinese self:An fMRI study显示文摘Cultural influences on the concept of self is a very important topic for social cognitive neuroscientific exploration, as yet, little if anything is known about this topic at the neural level. The present study investigates this problem by looking at the Chinese culture’s influence on the concept of self, in which the self includes mother. In Western cultures, self-referential processing leads to a memory performance advantage over other forms of semantic processing including mother-referential, other-referential and general semantic processing, and an advantage that is potentially localizable to the medial prefrontal cortex (MPFC). In Chinese culture, however, the behavioral study showed that mother-referential processing was comparable with self-referential processing in both memory per-formance and autonoetic awareness. The present study attempts to address whether similar neural correlates (e.g. MPFC) are acting to facilitate both types of referencing. Participants judged trait ad-jectives under three reference conditions of self, other and semantic processing in Experiment I, and a mother-reference condition replaced the other-reference condition in Experiment II. The results showed that when compared to other, self-referential processing yielded activations of MPFC and cingulate areas. However, when compared to mother, the activation of MPFC disappeared in self-referential processing, which suggests that mother and self may have a common brain region in the MPFC and that the Chinese idea of self includes mother. | ZHANG Li1,4, ZHOU Tiangang2, ZHANG Jian1, LIU Zuxiang1,2, FAN Jin3 & ZHU Ying11. Department of Psychology, Peking University, Beijing 100871, China 2. Key Laboratory of Cognitive Science, Graduate School and Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 3. Laboratory of Neuroimaging, Department of Psychiatry, Mount Sinai School of Medicine, NY 10029, USA 4. Department of Psychology, Capital Normal University, Beijing 100089, China | 2006 | Science China(Life Sciences)2006，49，1： | 7 |
| 2 | Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease显示文摘Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,respectively.Phosphorylated tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for AD.However,it is unknown whether these biomarkers have similar or complementary information in AD.Methods:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to AD.Analysis of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,respectively.Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD groups.VILIP-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal analyses.YKL-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at baseline.Conclusions:CSF levels of p-tau,VILIP-1,and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD.Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration.These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD. | Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge Gauthier the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 3 | MR影像体素形态学的阿尔茨海默病自动分类方法显示文摘为了确定轻度认知功能障碍(MCI)与阿尔茨海默病(AD)患者发生萎缩的重要脑区,实现正常老年人(NC)对照组、MCI与AD三组人群的分类,选择了178名被试的脑部MR影像,利用体素形态学与方差分析方法,考察NC,MCI与AD三组人群的MR影像中灰质体积差异;然后,采用递归特征消去法对特征进行降维;最后,利用线性支持向量机对这3种人群进行分类.实验结果表明,MCI组与NC组、MCI组与AD组、AD组与NC组的平均分类准确率分别为(90.2±1.3)%,(74.7±0.9)%,100%.对分类产生重要影响的脑区包括海马、海马旁回、杏仁核、梭状回和嗅皮层等.所提方法不仅能有效揭示NC,MCI,AD三组人群的脑灰质差异,阐明MCI患者与AD患者脑区发生萎缩的过程与特性,而且能准确区分这3组人群,具有显著的临床应用价值. | 郭圣文 池敏越 岑桂英 匡翠立 牛传筱 赖春任 吴效明 The Alzheimer's Disease Neuroimaging Initiative (ADNI) | 2015 | 东南大学学报(自然科学版)2015，45，2： | 4 |
| 4 | Alzheimer's disease progression model based on integrated biomarkers and clinical measures显示文摘 | Yue QIU Liang LI Tian-yan ZHOU Wei LU Alzheimer's Disease Neuroimaging Initiative | 2014 | Acta Pharmacologica Sinica2014，35，9： | 2 |
| 5 | Aberrant functional connectivity network in subjective memory complaint individuals relates to pathological biomarkers显示文摘Background:Individuals with subjective memory complaints(SMC)feature a higher risk of cognitive decline and clinical progression of Alzheimer’s disease(AD).However,the pathological mechanism underlying SMC remains unclear.We aimed to assess the intrinsic connectivity network and its relationship with AD-related pathologies in SMC individuals.Methods:We included 44 SMC individuals and 40 normal controls who underwent both resting-state functional MRI and positron emission tomography(PET).Based on graph theory approaches,we detected local and global functional connectivity across the whole brain by using degree centrality(DC)and eigenvector centrality(EC)respectively.Additionally,we analyzed amyloid deposition and tauopathy via florbetapir-PET imaging and cerebrospinal fluid(CSF)data.The voxel-wise two-sample T-test analysis was used to examine between-group differences in the intrinsic functional network and cerebral amyloid deposition.Then,we correlated these network metrics with pathological results.Results:The SMC individuals showed higher DC in the bilateral hippocampus(HP)and left fusiform gyrus and lower DC in the inferior parietal region than controls.Across all subjects,the DC of the bilateral HP and left fusiform gyrus was positively associated with total tau and phosphorylated tau181.However,no significant between-group difference existed in EC and cerebral amyloid deposition.Conclusion:We found impaired local,but not global,intrinsic connectivity networks in SMC individuals.Given the relationships between DC value and tau level,we hypothesized that functional changes in SMC individuals might relate to pathological biomarkers. | Kaicheng Li Xiao Luo Qingze Zeng Yeerfan Jiaerken Xiaojun Xu Peiyu Huang Zhujing Shen Jingjing Xu Chao Wang Jiong Zhou Min-Ming Zhang the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 2 |
| 6 | Neuroimaging standards for research into small vessel disease and its contreution to ageing and neurodegeneration显示文摘 | Wardlaw JM Smith EE Biessels GJ STandards for Reporting Vascular changes on nEuroimaging (STRIVE vl ) | 2013 | Lancet Neurol2013，12，： | 1 |
| 7 | Systematic review 显示文摘 | HULL AM Neuroimaging findings in post-traumatic stress disorder | 2002 | Br J Psychiatry2002，181，8： | 1 |
| 8 | MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults 显示文摘 | Dickerson BC Wolk DA Alzheimer' s Disease Neuroimaging Initiative | 2012 | Neurology2012，78，2： | 1 |
| 9 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration 显示文摘 | Wardlaw JM Smith EE Biessels GJ STandards for Reporting Vascular changes on nEuroimaging ( STRIVE vl ) | 2013 | Lancet Neurol2013，12，： | 1 |
| 10 | Pituitary volume and clinical trajectory in young relatives at risk for schizophrenia显示文摘 | Advances in neuroimaging research Shanghai Archives of Psychiatry Shah JL Tandon N Howard ER | 2015 | Psychologi- cal Medicine2015，45，13： | 1 |
| 11 | Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment显示文摘Grey matter(GM)alterations may contribute to cognitive decline in individuals with white matter hyperintensities(WMH)but no consensus has yet emerged.Here,we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment(WMH-MCI),43 WMH patients without cognitive impairment,and 55 healthy controls.Both WMH groups showed GM atrophy in the bilateral thalamus,fronto-insular cortices,and several parietal-temporal regions,and the WMH-MCI group showed more extensive and severe GM atrophy.The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients.Furthermore,the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control analyses.These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment. | Wenhao Zhu Hao Huang Shiqi Yang Xiang Luo Wenzhen Zhu Shabei Xu Qi Meng Chengchao Zuo Yong Liu Wei Wang Alzheimer’s Disease Neuroimaging Initiative | 2021 | Neuroscience Bulletin2021，37，6： | 1 |
| 12 | Fractionating verbal episodic memory in Alzheimer's disease显示文摘 | Wolk DA Dickerson BC Alzheimer's Disease Neuroimaging Initiative | | 0，，02： | 1 |
| 13 | w fi'om stroke 显示文摘 | Rossini PM Ahamura C Ferreri F et ah Neuroimaging ex- perimental studies on brain plasticity in reeovel | 2007 | Eura Medicophys2007，43，2： | 1 |
| 14 | Neuroimaging standards for research into small vessel disease and its contrution to ageing and neurodegeneration显示文摘 | Wardlaw JM Smith EE Biessels GJ STandards for Reporting Vascular changes on nEuroimaging (STRIVE vl ) | 2013 | Lancet Neurol2013，12，： | 1 |
| 15 | Focal hemosiderin deposits and β-amyloid load in the ADNI cohort显示文摘 | KantarciK GunterJL TosakulwongN Alzheimer's Disease Neuroimaging Initiative | 2013 | Alzheimers Dement2013，9，11： | 1 |
| 16 | Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease显示文摘 | Wolk DA Dickerson BC Alzheimer's Disease Neuroimaging Initiative | 2010 | Proc Natl Acad Sci U S A2010，107，10： | 1 |
| 17 | Genetic profiles of familial late-onset Alzheimer’s disease in China:The Shanghai FLOAD study显示文摘Compared with early-onset familial AD(FAD),the heritability of most familial lateonset Alzheimer’s disease(FLOAD)cases still remains unclear.However,there are few reported genetic profiles of FLOAD to date.In the present study,targeted sequencing of selected candidate genes was conducted for each of 90 probands with FLOAD and 101 unrelated matched normal controls among Chinese Han population.Results show a significantly lower rate of mutation in APP and PSENs,and APOE e4 genetic risk is higher for FLOAD.Among the Chinese FLOAD population,the most frequent variant was CR1 rs116806486[5.6%,95%CI(1.8%,12.5%)],followed by coding variants of TREM2(4.4%,95%CI(1.2%,10.9%))and novel mutations of ACE[3.3%,95%CI(0.7%,9.4%)].Next,we found that novel pathogenic mutations in ACE including frame-shift and nonsense mutations were in association with FLOAD regardless of APOE e4 status.Evidence from the Alzheimer’s disease Neuroimaging Initiative(ADNI)database also supported this finding in different ethnicities.Results of in vitro analysis suggest that frame-shift and nonsense mutations in ACE may be involved in LOAD through decreased ACE protein levels without affecting direct processing of APP. | Xin-Yi Xie Qian-Hua Zhao Qiang Huang a Eric Dammer Sheng-di Chen Ru-Jing Ren Gang Wang the Alzheimer’s Disease Neuroimaging Initiative | 2022 | Genes & Diseases2022，9，6： | 1 |
| 18 | Valence- specific regulation effects in a working memory task with emotional context 显示文摘 | Erk S Kleezar A Neuroimage H W | 2007 | Neuroimage2007，，37： | 1 |
| 19 | Hippocampal subregions are differentially affected in the progression to Alzheimer's disease显示文摘 | Greene S J Killiany RJ Alzheimer's Disease Neuroimaging Initiative | 2012 | Anatl Rec(Hoboken)2012，295，1： | 1 |
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