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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Improving the linenrity of piezoelectric ceramic actuators显示文摘 | NEWCOMB C V FLINN I | 1982 | Electron Lett1982，18，11： | 1 |
| 3 | Optimal treatment of hepatic abscess 显示文摘 | Hope W W Vrochides D V Newcomb W L | 2008 | Am Surg2008，74，2： | 1 |
| 4 | Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF dependent manner 显示文摘 | GILL Z P PERKS C M NEWCOMB P V | 1997 | J Biol Chem1997，272，25： | 1 |
| 5 | Effect modification by population dietary folate on theassociation between MTHFR genotype,homocysteine,and st-roke risk : a meta-analysis of genetic studies and randomisedtrials显示文摘 | Michael V Holmes Paul Newcombe Jaroslav A Hubacek | 2011 | The Lancet2011，378，9791： | 1 |
| 6 | Improving the Linearity of piezoelectric ceramic actuators显示文摘 | Flinn I | 1982 | Elecrtronws Letters1982，18，11： | 1 |
| 7 | Contribution of protein frac- tionation to depth of analysis of the serum and plasma proteomes显示文摘 | Faca V SJ Pitteri L Newcomb | 2007 | J Proteome Res2007，6，9： | 1 |
| 8 | Incorporation of Reliability into Mechanistic-empirical Pavement Design显示文摘 | Timm D H Newcomb D E Galambos T V | 2000 | Journal of the Transportation Research Board2000，1730，： | 1 |
| 9 | Leptin concentrations,leptin receptor polymorphisms,and coloreetal adenoma risk显示文摘 | Chia V M Newcomb P A Lampe J W | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，12： | 1 |
| 10 | Improving the linearity of piezoelectric ceramic actuators显示文摘 | Newcomb C V Flinn I | 1982 | Electronics Letters1982，18，11： | 1 |
| 11 | Improving the linearity of piezoelectric ceramic actuators 显示文摘 | Newcomb C V Flinn I | 1982 | Electronics Letters1982，18，11： | 1 |
| 12 | Magnetic resonance imaging changes in the pituitary gland following acute traumatic brain injury显示文摘 | Maiya B Newcombe V Nortje J | 2008 | Intensive Care Med2008，34，3： | 1 |
| 13 | Characterization of natural organic matter using high performance size exclusion chromatography显示文摘 | Pelekani C Newcombe G Snoeyink V | 1999 | Environmental Science and Technology1999，33，： | 1 |
| 14 | Improving the linearity of piezoelectric ceramic actuators显示文摘 | NEWCOMB C V FLINN I | 1982 | Electronics Letters1982，18，11： | 1 |
| 15 | Magnetic resonance imagingchanges in the pituitary gland following acute traumatic braininjury显示文摘 | Maiya B Newcombe V Nortje J | 2008 | Intensive Care Med2008，34，3： | 1 |
| 16 | Cadmium ex- posure and cancer mortality in the third national health and nutrition examination survey cohort 显示文摘 | Adams S V Passarelli M N Newcomb P A | 2012 | Occupational and Environmental Medicine2012，69，2： | 1 |
| 17 | Detailed analysis of mechanical properties ofSeBiLOYs I and II 显示文摘 | WHITING L V SAHOO M NEWCOMBE P D ZAVADIL R PETERS D T | 1999 | AFS Transactions1999，182，： | 1 |
| 18 | Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials 显示文摘 | Holmes M V Newcombe P Hubacek J A Sofat R Rieketts S L Cooper J | 2011 | Lancet2011，378，： | 1 |
| 19 | Optimal treat- ment of hepatic abscess显示文摘 | Hope W W Vrochides D V Newcomb W L | 2008 | Am Surg2008，74，2： | 1 |
| 20 | Amplification of cyclin D 1 and MDM-2 in oesophageal carcinoma显示文摘 | Morgan R J Newcomb P V Hardwick R H | 1999 | Eur J Surg One- ol1999，25，4： | 1 |
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