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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 4 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 5 | C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study显示文摘 | Sohail Q. Khan Onkar S. Dhillon Russell J. O’Brien Joachim Struck Paulene A. Quinn Nils G. Morgenthaler Iain B. Squire Joan E. Davies Andreas Bergmann Leong L. Ng | 2007 | Circulation2007，，16： | 2 |
| 6 | An unusual case of incidental rupture of liver hemangioma during labor显示文摘Cavernous hemangiomas are the most common benign tumors of the liver and are found in about 2% of autopsy patients. 1,2 The vast majority of these tumors are small and asymptomatic; however, there have been a few reported cases in which these lesions led to spontaneous fatal hemorrhage. 1,2 Although liver hemangiomas occur in both sexes, most studies point to a female predominance; one study reported a ratio of female predominance of 4. 5: 1.3 It has been suggested that estrogen may be associated with the growth of liver hemangiomas, but the incidence of these lesions in pregnancy and the effect on them of the increased estrogen levels during pregnancy are unknown. 2 Symptomatic liver hemangiomas have been treated by steroids, radiation therapy, surgical resection and recently embolization, but surgeons may sometimes be confronted with intraabdominal hemorrhage originating from rupture of asymptomatic liver hemangiomas. This case describes an incidental intraabdominal hemorrhage originating from a liver hemangioma in a 36 weeks twin pregnancy being delivered emergently by Cesarean section due to fetal distress. | TayfunGüng(o|¨)r Hakan Aytan (O|¨)merLütfiTapisiz Sema Zergeroglu | 2004 | Chinese Medical Journal2004，17，2： | 2 |
| 7 | Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter 显示文摘 | Procko E Ferrin- O' Connell I Ng SL | 2006 | Mol Cell2006，24，1： | 1 |
| 8 | 显示文摘 | Ng S C Ma Y F Chan H S O | 1999 | Synth Met1999，100，： | 1 |
| 9 | Transoral robotic surgery: supraglottic laryngectomy in a canine model 显示文摘 | Weinstein GS O' Malley B J Hockstein NG | 2005 | Laryngoscope2005，115，7： | 1 |
| 10 | 18-FDG-PET as a prognostic indicator in the treatment of aggressive Non- Hodgkir s Lymphma-eomparison -ith CT显示文摘 | Mikhaee Timothy AR O' Doherty MJ | 2000 | Leuk Lympho- ma2000，39，56： | 1 |
| 11 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael MZ O'Connor SM van Holst Pellekaan NG | | 0，，12： | 1 |
| 12 | Procalcitonin as a prognostic biomarker of severe sepsis and septic shock 显示文摘 | Azevedo JR Torres O J Czeczko NG | 2012 | Rev Col Bras Cir2012，39，6： | 1 |
| 13 | Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck : a clinicopathologic study of five cases and review of the literature 显示文摘 | Nikitakis NG Salama AR O'Malley BW | 2003 | Head Neck2003，25，6： | 1 |
| 14 | Re- duced accumulation of specific microRNAs in colorectal neoplasia 显示文摘 | Michael MZ O'Connor SM van Holst Pellekaan NG | 2003 | nol Cancer Res2003，1，12： | 1 |
| 15 | Synthesis,characterization,and electronic and optical properties of donor-acceptor conjugated polymers based on alternating bis(3-alkylthiophene) and pyridine moieties显示文摘 | Lu Hong-Fang Chan Hardy S O Ng Siu-Choon | 2003 | Macromolecules2003，36，： | 1 |
| 16 | A lingin-sepcific peroxidase in tobacco whose antisense suppression leads to vascular tissue modification 显示文摘 | Blee KA Choi JW O’Connell AP Schuch W Lewis NG Bolwell GP | 2003 | Phytochemistry2003，64，1： | 1 |
| 17 | New product design using FDMS and FANP under fuzzy environment显示文摘 | GO ¨ NG O ¨ R Z KILIC E DELICE | | 0，，11： | 1 |
| 18 | Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction显示文摘 | Sohail QK Kelvin NG Dhillon O | 2009 | Eur Heart J2009，30，9： | 1 |
| 19 | Serum vascular endothelial growth factor predicts invasion hepatocellular carcinoma:a prospective study显示文摘 | Poon R T Ng I O Lau C | 2001 | Ann Surge2001，233，2： | 1 |
| 20 | A model for flow induced by steady air venting and air sparging显示文摘 | Mei C C Cheng Z Ng C O | 2002 | Applied Mathematical Modeling2002，26，7： | 1 |
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