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| 1 | Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts显示文摘TGF-β并且 myostatin 是肌肉生长的二个很重要的管理者。两个生长因素被显示了通过一条 Smad3 依赖的小径发信号。不管多么迄今为止,在肌肉生长和区别的 Smad3 的角色没被调查。这里,我们证明 Smad3 空的老鼠减少了肌肉质量和显著骨胳的肌肉萎缩。与这一致,我们也在从 Smad3 空的老鼠孤立的肌肉织物发现增加的蛋白质 ubiquitination 和 ubiquitin E3 ligase 的提高的层次 MuRF1。Smad3 的损失也导致了有缺点的卫星房间(SC ) 功能。Smad3 空的 SC 为自强显示出减少的倾向,它可以导致 SC 数字的进步损失。确实,减少了 SC 数字从显示出严重肌肉浪费的症状的 Smad3 空的老鼠在骨胳的肌肉被观察。进一步,在主要 myoblast 的 vitro 分析,文化鉴别那 Smad3 空的 myoblasts 展览损害了增长,区别和熔化,导致萎缩的 myotubes 的形成。为分子的机制的搜索表明 Smad3 的损失在 Smad3 空的肌肉和 myoblasts 导致增加的 myostatin 表示。给那 myostatin 是一个否定管理者,我们假设增加那 myostatin 层次为在 Smad3 空的老鼠的衰退显型负责。与这个理论一致,在 Smad3 空的老鼠的 myostatin 的 inactivation 救肌肉萎缩显型。 | XiaojiaGe CraigMcFarlane AnuradhaVajjala SudarsanareddyLokireddy Zhi HuiNg Chek KunTan Nguan SoonTan WalterWahli MridulaSharma RaviKambadur | 2011 | Cell Research2011，21，11： | 5 |
| 2 | Matricellular Proteins: A Sticky Affair with Cancers显示文摘 | Han Chung Chong Chek Kun Tan Royston-Luke Huang Nguan Soon Tan Dominic Fan | 2012 | Journal of Oncology2012，，： | 2 |
| 3 | Halofuginone suppresses T cell proliferation by blocking proline uptake and inducing cell apoptosis显示文摘 | Tony L.H. Chu Qiunong Guan Christopher Y.C. Nguan Caigan Du | 2013 | International Immunopharmacology2013，，4： | 2 |
| 4 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 5 | Intraoperative laparoscopic renal ultrasonography:use in advanced laparoscopic renal surgery显示文摘 | Fazio LM Downey D Nguan CY | | 0，，04： | 1 |
| 6 | Laparoscopic manage-ment of advanced renal cell carcinoma with level I renal veinthrombus显示文摘 | Kapoor A Nguan C Al-Shaiji TF | 2006 | Urology2006，68，： | 1 |
| 7 | Prospective Comparison of Magnetic Resonance Angiography with Selective Renal Angiography for Living Kidney Donor Assessment显示文摘 | Christopher Neville Andrew A. House Christopher Y. Nguan Kenneth A. Beasley David Peck Lisa M.F. Thain Richard Rankin Vivian C. McAlister Alison R. Spouge Patrick P.W. Luke | 2008 | Urology2008，，3： | 1 |
| 8 | Intraoperative laparo- scopic renal ultrasonography: use in advanced laparoseopic renal surgery 显示文摘 | Fazio LM Downey D Nguan CY | 2006 | Urology2006，68，4： | 1 |
| 9 | Intraopera- rive laparoscopic renal ultrasonography: use in ad- vanced laparoscopic renal surgery显示文摘 | Fazio L M Downey D Nguan C Y etal | 2006 | Urology2006，68，： | 1 |
| 10 | Antithrombotic actions of selective inhibitors of blood coagulation factor Xa in rat models of thrombosis显示文摘 | Wong P C Crain E J Nguan O | 1996 | Thromb Res1996，83，： | 1 |
| 11 | Room- temperature luminescence of excitons in ZnO/MgZnO multiple quantum wells on lattice- matched substrates 显示文摘 | Chia C H Nguan | 2000 | Appl Phys Lett2000，77，7： | 1 |
| 12 | Intraoperative laparoscopic renal ultrasonography: use in advanced laparoscopic renal surgery显示文摘 | FAZIO LM DOWNEY D NGUAN CY | 2006 | Urology2006，68，4： | 1 |
| 13 | Molecular epidemiology of enterovirus outbreaks in Canada during 1991-1992:identification of echovirus 30 and coxsackievirus B1 strains by amplicon sequencing显示文摘 | Drebot MA Nguan CY Campbell JJ | 1994 | J Med Virol1994，44，4： | 1 |
| 14 | Renal tubular epithelial cells as immunoregulatory cells in renal allograft rejection显示文摘 | Nguan CY Du C | | 0，，03： | 1 |
| 15 | Renal artery pseudoaneurysm of infectious etiology: a life-threatening complication after renal transplantation 显示文摘 | Nguan CY Luke PP | 2006 | Urology2006，68，3： | 1 |
| 16 | High therapeutic index of factor C Sushi peptides:Potent antimicrobials against Pseudomonas aeruginosa显示文摘 | Yin HY Bow H Nguan ST | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 17 | Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes显示文摘 | Nguan ST Liliane M Beatrice D | 2005 | J Steroid biochem Mol Biol2005，93，： | 1 |
| 18 | The Biotechnology Industry and Strategies of Biodiversity Conservation:the Influence of Managerial Interpretations and Risk Propensity显示文摘 | Sharma S Nguan O | 1999 | Business Strategy of Environment1999，，8： | 1 |
| 19 | Intraoperative laparoscopic renal uhrasonography:use in advanced laparoscopic renal sur- gery显示文摘 | Fazio LM Downey D Nguan CY | 2006 | Urology2006，68，4： | 1 |
| 20 | Molecular epidemiol ogy of enterovirus outbreaks in Canada during 1991--1992: iden tification of echovirus 30 and coxsackievirus B1 strains by ampli con sequencing显示文摘 | Drebot MA Nguan CY Campbell JJ | 1994 | J Med Virol1994，44，4： | 1 |
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