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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 4 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 5 | A novel genetic algorithm for solving production and transportation scheduling in a two - stage sup- ply chain显示文摘 | Zegordi S Abadi I Nia M | 2010 | Computers & Industrial Engineering2010，58，3： | 1 |
| 6 | PVAc microspheres viasemicontinuous emulsion polymerization: synthesis,characterization, kinetic, and surface morphology studies 显示文摘 | Mohsen -nia M Doulabi F S M | 2011 | The Journal of Adhesion2011，87，10： | 1 |
| 7 | Removal of Cu^2+ and Ni^2+ from wastewater with a chelating agent and reverse osmosis processes显示文摘 | MOHSEN NIA M MONTAZERI P MODARRESS H | 2007 | Desalination2007，217，1： | 1 |
| 8 | Analysis of resistance of concrete target penetration of eroding long rod projectile regarding flow field around the projectile tip显示文摘 | Alavi Nia A Zolfaghari M Mahmoudi A H Nili M | 2013 | International Journal of Impact Engineering2013，57，： | 1 |
| 9 | Pathogenic T cells in cerebral malaria显示文摘 | Rénia L Potter SM Mauduit M | 2006 | Int J Parasitol2006，36，5： | 1 |
| 10 | Germline transformation of the butterfly Bicyclus anynana 显示文摘 | MARCUS J M RAMOS D M ANTO'NIA MONTEIRO | 2004 | The Royal Society2004，271，： | 1 |
| 11 | Transponder calibration of the Envisat RA-2 altimeter Ku band sigma naught显示文摘 | N. Pierdicca C. Bignami M. Roca P. Féménias M. Fascetti M. Mazzetta C.N. Loddo A. Martini S. Pinori | 2012 | Advances in Space Research2012，，： | 1 |
| 12 | The Global Monitoring for Environment and Security (GMES) Sentinel-3 mission显示文摘 | C. Donlon B. Berruti A. Buongiorno M.-H. Ferreira P. Féménias J. Frerick P. Goryl U. Klein H. Laur C. Mavrocordatos J. Nieke H. Rebhan B. Seitz J. Stroede R. Sciarra | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 13 | A multi-population genetic algorithm for transportation scheduling显示文摘 | Zegordi S H Beheshti Nia M A | 2009 | Transportation Research Part E2009，45，6： | 1 |
| 14 | Properties of Baked Foams Based on Cassa- va Starch, Sugarcane Bagasse Fibers and Montmorillonite 显示文摘 | VERCELHEZE A E S FAKHOURI F M DALL'ANTO- NIA L H | 2012 | Carbohydrate Polymers2012，87，： | 1 |
| 15 | Adsorption of Ag(Ⅰ) on glycidyl methacrylate/ N,N'-methylene bis-acrylamide chelating resins with embedded iron oxide显示文摘 | ATIA A DO)NIA A M EL-BORAEY H A | 2006 | Separation and Purification Technology2006，48，3： | 1 |
| 16 | Carbon nitrogen and antioxidant znzyme responses of Potamogeton crispus to both low light and high nutrient stresses显示文摘 | ZHANG M CAO T NIA L | 2010 | Environmental and Experimental botany2010，68，1： | 1 |
| 17 | A generalized ABFT technique using a fault tolerant neural network 显示文摘 | Nia A M Mohammadi K | 2007 | Jour- nal of circuits systems and computers2007，16，3： | 1 |
| 18 | Cardiac troponin I release in heart transplantation显示文摘 | Hossein- Nia M Hott DW Anderson JR | 1996 | Ann Thorac Surg1996，61，： | 1 |
| 19 | Synchronization of mammalian cells with respect to the mitotic cycle显示文摘 | NIAS A FOX M | 1971 | Cell Tissue Kinet1971，4，4： | 1 |
| 20 | Association of Changes in Bone Remodeling and Coronary Calcification in Hemodialysis Patients: A Prospective Study显示文摘 | Daniela Veit Barreto Fellype de Carvalho Barreto Aluízio Barbosa de Carvalho Lilian Cuppari Sérgio Antonio Draibe Maria Aparecida Dalboni Rosa Maria Affonso Moyses Kátia Rodrigues Neves Vanda Jorgetti Márcio Miname Raul D. Santos Maria Eugênia F. Canziani | 2008 | American Journal of Kidney Diseases2008，，6： | 1 |
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