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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis显示文摘We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions. | Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos Konstantinos P Economopoulos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 27 |
| 3 | Shear strength of rockfill显示文摘 | Nick B Bjorn K | 1981 | JournalGeotechnical Engineers Division American SocietyCivil of Engineering1981，，7： | 2 |
| 4 | Manual aspiration thrombectomy in acute ST elevation myocardial infarction:New gold standard?显示文摘Percutaneous coronary intervention(PCI) is the preferred method to treat ST segment myocardial infarction(STEMI).The use of thrombus aspiration(TA) may be particularly helpful as part of the PCI process,insofar as the presence of thrombus is essentially a universal component of the STEMI process.This article reviews evidence favoring the routine use of TA,and the limitations of these data.Based on current evidence,we consider TA to be an important maneuver during STEMI PCI,even in the absence of visible angiographic thrombus,and recommend it whenever the presence of thrombus is likely. | Brent Rochon Youssef Chami Rajesh Sachdeva Joe K Bissett Nick Willis Barry F Uretsky | 2011 | World Journal of Cardiology2011，3，2： | 2 |
| 5 | Shear strength of rockfill显示文摘 | NICK B BJORN K | 1981 | Journal of the Geotechnical Engineering Division ASCE1981，107，7： | 1 |
| 6 | Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Aetlvin and Inhibin 显示文摘 | NICKS K M PERRIEN D S AKEL N S | 2009 | Mol Cell Endocrinol2009，310，12： | 1 |
| 7 | Selective activation and functional significance of p38a mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils显示文摘 | NICK J A AVDI N J YOUNG S K | 1999 | J Clin Invest1999，103，6： | 1 |
| 8 | The effects oftime-of-exposure of alginate-coated rat embryos to calciumchloride on in vitro development and pregnancy maintenance inewes with alginate-coated 4-or 8-cell embryos显示文摘 | MEREDITH S NICKS D K KIESLING D O | 1990 | Theriog-enology1990，33，： | 1 |
| 9 | Digital watermarking using complex wavelets显示文摘 | PATRICK L NICK K | 2000 | IEEE Transactions on Signal Processing2000，2，3： | 1 |
| 10 | Motion estimation using a complex-valued wavelet transform显示文摘 | JULIAN M NICK K | 1998 | IEEE Transactions on Signal Processing1998，46，4： | 1 |
| 11 | Towards the development of a chemical kinetic model for the homogeneous oxidation of mercury by chlorine species显示文摘 | REBECCA N S JOHN C K NICK M M | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 12 | A novel micromachined pump based on thick-film piezoelectric actuation 显示文摘 | MICHAEL K NICK H ALAN G R | 1998 | Sens Actuators A1998，70，： | 1 |
| 13 | Land zoning and local discretion in the Korean planning system显示文摘 | Nick G Kwang S K | 2001 | Land Use Policy2001，18，3： | 1 |
| 14 | Risk ofthromboembolic disease in patients undergoing laparoscopic gyne-cologic surgery显示文摘 | NICK A M SCHMELER K M FRUMOVITZ MM | 2010 | Obstet Gynecol2010，116，4： | 1 |
| 15 | Synthesis, structural characterization and in vitro cytotoxicity of organotin (IV) : Derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2- mercaptobenzothiazole and 2-mercapto-nicotinic acid 显示文摘 | Xanthopoulou M N Hadjikakou S K Nick H | 2003 | Inorganic and Analytical Chemistry2003，96，23： | 1 |
| 16 | Artificial activation of porcine oocytes matured in vitro显示文摘 | PRATHER R S EICHEN P A NICKS D K | 1991 | Molecular Reproduction Development1991，28，： | 1 |
| 17 | Nomore blind dates with calcite: Fluid-flow vs. fault-slip along the Očkov thrust, Prague Basin显示文摘Dating of fracture-filling calcitewith U-Pb geochronology is becoming a rapidly adopted technique for determining the absolute timing of brittle deformation in the upper crust.Slickenfibre calcite is a desirable target,as it precipitates between individual fault slip displacement events,and provides additional kinematic information.Here we present a case study of slickenfibres formed on the Očkov thrust in the Lower Palaezoic Prague Basin,Bohemian Massif,utilising a combination of petrographic and in situ methods.We demonstrate that slickenfibre external textures can be preserved,whilst internally primary textures are removed by fluid infiltration and recrystallization,leading to variable U and Pb mobilisation.One slickenfibre yielded a date of ca.250 Ma,which we interpret as recording fault slip along the Očkov thrust.Another cross-cutting slickenfibre yielded more scattered U-Pb data,with an imprecise apparent age around ca.95 Ma.This slickenfibre is recrystallised,destroying the primary textures,and exhibits element mobility.The meaning of this younger apparent age is therefore questionable;whereas it likely reflects Cretaceous U and Pb mobility assisted by fluid-flow along the fault plane,it may not reflect a period of fault slip.Our results demonstrate that slickenfibre-based U-Pb dates do not unequivocally relate to fault motion,and that petrographic and elemental analyses are important requirements for interpreting calcite U-Pb data. | Nick M.W.Roberts JiříŽák František Vacek JiříSláma | 2021 | Geoscience Frontiers2021，12，4： | 1 |
| 18 | The macrophage scavenger receptor type A is expressed by activated macrophage and protects the host against lethal endotoxic shock 显示文摘 | Richard H Nick P Satish K | 1997 | J Exp Med1997，186，10： | 1 |
| 19 | Validity of SF-12 summary scores in a Greek general population显示文摘 | Nick K Evelina P Dimitris N | 2007 | Health and Quality of Life Outcomes2007，，5： | 1 |
| 20 | A novel micromachined pump based on thick-film piezoelectric actuation显示文摘 | MICHAEL K NICK H EVANS G | 1998 | Sensors and Actuctors1998，70，12： | 1 |
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