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| 1 | 基于证据的质量改进方法降低极低出生体重儿入院低体温发生率的多中心研究方案显示文摘1项目负责人:山东大学附属省立医院于永慧主任医师,南京市妇幼保健院余章斌副主任医师作为项目的监理。2多中心协作组:山东省9个地(市)16家三级甲等医院的NICU参加基于证据的质量改进(EPIQ)项目。各参研单位NICU的科室主任负责研究设计、诊断标准和质量控制方案的讨论制定,医疗组长负责执行试验方案、收集病例资料、记录体温及核查各项措施的实施情况,护士长负责各个时间点的体温测量以及体温测量过程中的质量控制。 | 山东省多中心NICU早产儿入院低体温质量改进临床研究协作组 于永慧 | 2019 | 中国循证儿科杂志2019，14，2： | 24 |
| 2 | 江苏省13家医院极早产儿死亡危险因素分析显示文摘目的探讨影响极早产儿死亡的相关危险因素,为后续质量改进提供依据。方法回顾性分析2018年1月至2019年12月江苏省新生儿重症监护室(neonatal intensive care unit,NICU)母乳喂养质量改进临床研究协作组13家协作单位NICU收治的胎龄<32周极早产儿临床资料,根据患儿预后和死亡时间分为存活组、新生儿早期死亡组、新生儿晚期死亡组和新生儿期后死亡组,比较各组患儿临床资料,应用SPSS 26.0统计软件采用多因素Logistic回归分析影响早产儿死亡的危险因素。结果共纳入胎龄<32周极早产儿2467例,存活2127例(86.2%),死亡340例(13.8%),其中新生儿早期死亡251例(73.8%),新生儿晚期死亡62例(18.2%),新生儿期后死亡27例(7.9%)。Logistic多元回归分析显示,胎龄(OR=0.835,95%CI 0.751~0.929)、出生体重(OR=0.998,95%CI 0.997~0.998)、产前应用糖皮质激素(OR=0.481,95%CI 0.365~0.635)是极早产儿死亡的保护因素(P均<0.05);1 min Apgar≤3分(OR=2.459,95%CI 1.743~3.467)、使用有创机械通气(OR=2.308,95%CI 1.730~3.078)、肺出血(OR=3.888,95%CI 2.383~6.345)是新生儿早期死亡的危险因素(P均<0.05);使用有创机械通气(OR=3.598,95%CI 2.119~6.111)、Ⅲ~Ⅳ级脑室内出血或囊性脑室周围白质软化(OR=2.328,95%CI 1.266~4.280)、肺出血(OR=4.055,95%CI 1.990~8.261)、Ⅱ~Ⅲ期坏死性小肠结肠炎(OR=3.933,95%CI 2.157~7.174)是新生儿晚期和新生儿期后死亡的危险因素(P均<0.05)。结论胎龄、出生体重、产前应用糖皮质激素是极早产儿死亡的保护因素,使用有创机械通气、1 min Apgar≤3分、肺出血、Ⅲ~Ⅳ级脑室内出血或囊性脑室周围白质软化和Ⅱ~Ⅲ期坏死性小肠结肠炎是极早产儿死亡的危险因素。 | 江苏省NICU母乳喂养质量改进临床研究协作组 韩树萍 | 2021 | 中华新生儿科杂志(中英文)2021，36，5： | 6 |
| 3 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 4 | Content-Based Multimedia Information Retrieval: State of the art and Challenges 显示文摘 | MICHAEL S LEW NICU SEBE CHABANE DJERABA | 2006 | ACM Transactions on Multimedia Computing Communications and Applications2006，2，1： | 1 |
| 5 | Periodontitis is associated with platelet activation显示文摘 | Dimitris Papapanagiotou Elena A. Nicu Sergio Bizzarro Victor E.A. Gerdes Joost C. Meijers Rienk Nieuwland Ubele van der Velden Bruno G. Loos | 2008 | Atherosclerosis2008，，2： | 1 |
| 6 | Understanding solvent effects in vibrational circular dichroism spectra: 显示文摘 | Nicu VP Baerends EJ Polavarapu PL | 2012 | J Phys Chem A2012，116，32： | 1 |
| 7 | Hyper-reactive PMNs in FcgammaRIla 131 H/H genotype periodontitis patients显示文摘 | Nicu EA Van der Velden U Everts V | 2007 | J Clin Periodontol2007，34，11： | 1 |
| 8 | Severe retinopathy of prematurity in infants < 30 weeks' gestation in New South Wales and the Australian Capital Territory from 1992 to 2002显示文摘 | Todd DA Wright A Smith J NICUS Group | 2007 | Arch Dis Child Fetal Neonatal Ed2007，92，4： | 1 |
| 9 | Postharvest quality of apple predicted by NIR-spectroscopy: Study of the effect of biological variability on spectra and model performance显示文摘 | Els Bobelyn Anca-Sabina Serban Mihai Nicu Jeroen Lammertyn Bart M. Nicolai Wouter Saeys | 2009 | Postharvest Biology and Technology2009，，3： | 1 |
| 10 | Comparing salient point detectors显示文摘 | Nicu Sebe Michael S Lew | 2003 | Pattern Recognition Letters2003，24，13： | 1 |
| 11 | Elevated platelet and leukocyte response to oral bacteria in periodontitis 显示文摘 | Nicu EA Vander Velden U Nieuwland R | 2009 | J Thromb Haemost2009，7，1： | 1 |
| 12 | Perlodontitis is associated with platelet activation 显示文摘 | Papapanaqiotou D Nicu EA Bizzarro S | 2009 | Atherosclerosis2009，202，2： | 1 |
| 13 | Corruption and Decentralization in Local Public Administration显示文摘 | Nicu B | 2012 | Valahian Journal of Economic Studies2012，3，1： | 1 |
| 14 | Experimental and theoretical investigations on nonlinear resonances of composite buckled microbridges 显示文摘 | Nicu L Bergaud C | 1999 | Journal of Applied Physics1999，86，10： | 1 |
| 15 | Comparing salient point detectors显示文摘 | Nicu Sebe Michael S Lew | 2003 | Pattern Recognition Letters2003，24，13： | 1 |
| 16 | Research on the influence of water stress on photosynthetic parameters at some species of succulent flower plants显示文摘 | Cristescu M Anton D Nicu C Mandǎ M | | 0，，52： | 1 |
| 17 | Postharvest quality of apple predicted by NIR-spectroscopy: study of the effect of biological variability on spectra and model per- formance 显示文摘 | BOBELYN E SERBAN A-S NICU M | 2010 | Postharvest Biology and Technology2010，55，3： | 1 |
| 18 | Documenting the staff perceptions of open ward family room units显示文摘 | Domanico R Davis D K Coleman NICU design versus single 30 (5) : 34 dilemma: Parent and F Davis B O | 2010 | Journal of Perinatology2010，3351，： | 1 |
| 19 | Postharvest quality of apple predicted by NIR-spectroscopy: Study of the effect of biological variability on spectra and model performance显示文摘 | Els Bobelyn Anca-Sabina Serban Mihai Nicu Jeroen Lammertyn Bart M. Nicolai Wouter Saeys | 2009 | Postharvest Biology and Technology2009，，3： | 1 |
| 20 | Content Based Multimedia Information Retrieval: State of the Art and Challenges 显示文摘 | Michael S Lew Nicu Sebe Chabane Djeraba | 2006 | ACM Transactions on Muhimedia Computing Communications and Applications2006，2，1： | 1 |
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