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| 1 | Synchronous isolated splenic metastasis from colon carcinoma and concomitant splenic abscess:A case report and review of the literature显示文摘This study aimed to describe a case in which an isolated splenic metastasis was synchronous with the colonic primary and a concomitant splenic abscess was associated. A wide review of the literature was also performed. A 54-year-old woman with abdominal pain and fever was admitted to our department. Abdominal CT revealed two low-density areas in the spleen and wall-thickening of the left colonic flexure,which was indistinguishable from the spleen parenchyma. The patient underwent emergency celiotomy,with the presumptive diagnosis of obstructing colon carcinoma of the splenic flexure,and concomitant splenic abscess. Subtotal colectomy and splenectomy were performed. Pathological findings were consistent with mucinous colonic carcinoma,synchronous isolated splenic metastasis and concomitant splenic abscess. This paper is also a review of the existing literature on the association between colorectal cancer and splenic metastasis. Only 41 cases of isolated splenic metastasis from colon carcinoma have been reported in the literature. This report is the third described case of synchronous isolated splenic metastasis from colon carcinoma. Only one case with concomitant splenic abscess has been previously reported. When obstructing left-sided colorectal cancer is suspected,careful CT examination can allow early diagnosis of splenic involvement by the tumor. The literature review suggests that there might be a significant improvement in survival following splenectomy for a metachronous isolated splenic metastasis from colon carcinoma. Prognosis for synchronous splenic metastasis seems to be related to the advanced stage of the disease. Nevertheless,no definitive conclusions can be drawn because of the small number of cases. | Adolfo Pisanu Alberto Ravarino Riccardo Nieddu Alessandro Uccheddu | 2007 | World Journal of Gastroenterology2007，13，41： | 9 |
| 2 | Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report显示文摘BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare.Polycythemia is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and obesity.Here we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated polycythemia.CASE SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous uterus.She suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several months.Laboratory analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of polycythemia.Arterial blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 mmHg.Abdominal computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 cm.To reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic hysterectomy.The uterus weighed 5400 g and the histology confirmed a diagnosis of leiomyoma.We did not find increased erythropoietin levels in the supernatant of the myomatous uterine tissue.There were no complications.On postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,respectively.Arterial blood gas analysis after surgery showed a pO2 of 144.7 mmHg.These results suggested the diagnosis of myomatous erythrocytosis syndrome.The patient was discharged on the second postoperative day in very good condition with no symptoms.CONCLUSION We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and obesity.Multiple VTE risk factors warranted a laparoscopic approach. | Antonio Macciò Giacomo Chiappe Fabrizio Lavra Elisabetta Sanna Romualdo Nieddu Clelia Madeddu | 2019 | World Journal of Clinical Cases2019，7，19： | 5 |
| 3 | Synthesis of Substituted Benzofurans via Microwave- Enhanced Catch and Release Strategy显示文摘 | Luca L D Giaeomelli G Nieddu G | 2008 | J Comb Chem2008，10，： | 1 |
| 4 | Finite mixture models for mapping spatially dependent disease counts显示文摘 | ALFO M NIEDDU L VICARI D | 2009 | Biometrical Journal2009，51，1： | 1 |
| 5 | A Facile Approach to the Synthesis of Chiral 2 - Substituted Benzofurans 显示文摘 | Luca L D Giacomelli G Nieddu G | 2007 | J Org Chem2007，72，： | 1 |
| 6 | Preparation and biodegradation of clay composites of PLA 显示文摘 | Nieddu E Mazzucco L Gentile P Benko T Balbo V Mandrile R Cia- rdelli G | 2009 | Reactive & Functional Polymers2009，69，： | 1 |
| 7 | Ileocecal valve imaging on computed tomographic colonography 显示文摘 | Regge D Gallo T Nieddu G | 2005 | Abdom Imaging2005，30，1： | 1 |
| 8 | Isolation of helicobacter pylori from sheep—implications for transmission to humans显示文摘 | Maria P Dore Antonia R Sepulveda Hala El-Zimaity Yoshio Yamaoka Michael S Osato Kato Mototsugu Antonio M Nieddu Giuseppe Realdi David Y Graham | 2001 | The American Journal of Gastroenterology2001，，5： | 1 |
| 9 | Acid and base degraded products of ketorolac显示文摘 | Salaris M Nieddu M Rubattu N | | 0，，02： | 1 |
| 10 | Enantiomeric Separation by HPLC of 1,4-Dihydropyridines with Vancomycin as Chiral Selector显示文摘 | Boatto G Nieddu M Faedda M V | 2003 | Chirality2003，15，6： | 1 |
| 11 | A kernel k means procedure for classification显示文摘 | Cifarelli C Nieddu L Seref O | 2007 | Computers Operations Research2007，34，24： | 1 |
| 12 | Preparation and Biodegradation of Clay Composites of PLA显示文摘 | Nieddu E Mazzucco L Gentile P | 2009 | React Funct Polym2009，69，： | 1 |
| 13 | Electron micros-copy and composition of raw acom starch in relation to in vivostarch digestibility显示文摘 | CAPPAI M G ALESSO G A NIEDDU G | 2013 | Food Funct2013，4，6： | 1 |
| 14 | Highly active catalysts for the telomerization of crude glycerol with 1,3-butadiene显示文摘 | Palkovits R Nieddu I Gebbink R | 2008 | Chemsuschem2008，1，3： | 1 |
| 15 | Cross-reactivilies of 41 new amphetamine designer drugs to EMIT immunoassays 显示文摘 | Maria Nieddu Claudia Trignano Lucia Burrai | 2013 | Forensic Toxicology2013，31，1： | 1 |
| 16 | Cytogenetic investigation on 30 bladder carcinomas显示文摘 | Vanni R Scarpa RM Nieddu M | 1988 | Cancer Genet Cytogenet1988，30，1： | 1 |
| 17 | Palladium-Based Telomerization of 1,3-Butadiene with Glycerol Using Methoxy-Functionalized Triphenylphosphine Ligands显示文摘 | Palkovits R Nieddu I Kruithof C A | 2008 | Chemistry-a European Journal2008，14，29： | 1 |
| 18 | LC - MS analysis of trimethoxyampbetamine designer drugs ( TMA series) from urine samples显示文摘 | Nieddu M Boatto G Pirisi MA | 2008 | J Chromatogr B Analyt Teehnol Biomed Life Sei2008，867，1： | 1 |
| 19 | A comparative analysis of European and American eel ( AnguiUa anguilla and Anguil- la rostrata ) genomic DNA: 5S rDNA polymorphism permits the distinction between the two populations 显示文摘 | Nieddu M Pichiri G Coni P | 1998 | Genome1998，41，5： | 1 |
| 20 | Synthe- sis of substituted benzofurans via catch and release strategy 显示文摘 | Luca L D Giampaolo Giacomelli Nieddu G | 2008 | J Comb Chem2008，10，： | 1 |
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