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| 1 | Chronic hepatitis B in 2014: Great therapeutic progress, large diagnostic deficit显示文摘This review analyzes progress and limitations of diagnosis, screening, and therapy of patients with chronic hepatitis B infection. A literature review was carried out by framing the study questions. Vaccination in early childhood has been introduced in most countries and reduces the infection rate. Treatment of chronic hepatitis B can control viral replication in most patients today. It reduces risks for progression and may reverse liver fibrosis. The treatment effect on development of hepatocellular carcinoma is less pronounced when cirrhosis is already present. Despite the success of vaccination and therapy chronic hepatitis B remains a problem since many infected patients do not know of their disease. Although all guidelines recommend screening in high risk groups such as migrants, these suggestions have not been implemented. In addition, the performance of hepatocellular cancer surveillance under real-life conditions is poor. The majority of people with chronic hepatitis B live in resource-constrained settings where effective drugs are not available. Despite the success of vaccination and therapy chronic hepatitis B infection remains a major problem since many patients do not know of their disease. The problems in diagnosis andscreening may be overcome by raising awareness, promoting partnerships, and mobilizing resources. | Claus Niederau | 2014 | World Journal of Gastroenterology2014，20，33： | 13 |
| 2 | Trypsinogen activation and glutathione content are linked to pancreatic injury in models of biliary acute pancreatitis显示文摘 | Reinhard Lüthen James H. Grendell Claus Niederau Dieter H?ussinger | 1998 | International Journal of Pancreatology1998，，3： | 2 |
| 3 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Sterilization,toxicity,b iocompatibility and clinical applications of poly-lactic acid /polyglycolic acid copolymers显示文摘 | Athanasiou KA Niederauer GG Agrawal CM | | 0，，02： | 1 |
| 5 | Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin 显示文摘 | Niederau C Ferrell LD Grendell JH | 1985 | Gastroenterology1985，88，51： | 1 |
| 6 | Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double blind, placebo controlled trial显示文摘 | Niederau C Strohmeyer G Heintges T Peter K Gopfert E (Leich Study Group) | 1998 | Hepato-Gastroenterology1998，45，21： | 1 |
| 7 | 显示文摘 | Athanasiou K A Niederauer G G Agrawal C M | 1995 | Clin Podiatr Med Surg1995，12，3： | 1 |
| 8 | Cardiac troponin T in the diagnosis and follow up of suspected myocarditis 显示文摘 | Lauer B Niederau C Kuhl U | 1998 | Dtsch Med Wochenschr1998，，： | 1 |
| 9 | Long - term follow-up of HBeAg - positive patients treated with interferon alfafor chronic hepatitis B显示文摘 | Niederau C Heintges T Lange S | 1996 | N Engl J Med1996，334，22： | 1 |
| 10 | Iron over load and atherosclerosis显示文摘 | Niederau C | 2000 | Hepatology2000，32，3： | 1 |
| 11 | Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B显示文摘 | Niederau C Heintges T Lange S | 1996 | N Engl J Med1996，334，： | 1 |
| 12 | In vitro attachment of osteoblast-like cells to osteoceramic materials 显示文摘 | Keller JC Collins JG Niederauer GG | 1997 | Dent Mater1997，13，： | 1 |
| 13 | Cardiac troponin T in the diagnosis and follow up of suspected myocarditis显示文摘 | Lauer B Niederau C Kuhl U | 1998 | Dtsch Med Wochenschr1998，123，14： | 1 |
| 14 | Long-term followup of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B显示文摘 | Niederau C Heintges T Lange S | | New England Journal of Medicine0，，： | 1 |
| 15 | Long-term follow-up of HBeAg-positive patients treated with interferon alpha for chronic hepatitis B显示文摘 | Niederau C Heintges T Lange S | 1996 | N Engl J Med1996，334，22： | 1 |
| 16 | Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B显示文摘 | Niederau C Heintges T Lange S | 1996 | N Eng J Med1996，334，： | 1 |
| 17 | Long-term follow-up of HBeAg-positive patients treated with interferon-a for chronic hepatitis B显示文摘 | Niederau C Heintges T Lange S | 1996 | N Engl J Med1996，334，： | 1 |
| 18 | Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B显示文摘 | NIEDERAU C HEINTGES T LANGE S | 1996 | N Engl J Med1996，334，： | 1 |
| 19 | Iron overload and atherosclerosis显示文摘 | | 2000 | Hepatology2000，32，3： | 1 |
| 20 | Pancreatic exocrine secretion in acute experimental pancreatitis显示文摘 | Niederau C Niederau M Luthen R | 1990 | Gastroenterology1990，99，4： | 1 |
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