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| 1 | Loss of Aβ-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis显示文摘The Merkel cell-neurite complex initiates the perception of touch and mediates Ab slowly adapting type I responses.Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation,whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa.To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex,healthy oral mucosal epithelium and lesional oral mucosal epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry(the avidin-biotin-peroxidase complex and double immunofluorescence methods)using pan cytokeratin,20(K20,a Merkel cell marker),and neurofilament 200(NF200,a myelinated Ab-and Ad-nerve fibre marker)antibodies.NF200-immunoreactive(ir)nerve fibres in healthy tissues and in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis were counted and statistically analysed.In the healthy oral mucosa,K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected.In the lesional oral mucosa of lichen planus and hyperkeratosis patients,extremely rare NF200-ir nerve fibres were detected only in the lamina propria.Compared with healthy tissues,lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium.Lichen planus and hyperkeratosis were associated with the absence of Ab-nerve endings in the oral mucosal epithelium.Thus,we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosal epithelium is impaired in lichen planus and hyperkeratosis. | Daniela Calderon Carrion Yiiksel Korkmaz Britta Cho Marion Kopp Wilhelm Bloch Klaus Addicks Wilhelm Niedermeier | 2016 | International Journal of Oral Science2016，8，1： | 2 |
| 2 | Isoformselective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia:a novel therapeutic approach显示文摘 | Niedermeier M Hennessy BT Knight ZA | 2009 | Blood2009，113，22： | 1 |
| 3 | A methodology to pre- dict the power consumption for data centres 显示文摘 | Basmadjian R Ali N Niedermeier F | 2011 | Proceedings of e- Energy2011，11，3： | 1 |
| 4 | Detection of coastlines in SAR images using wavelet methods显示文摘 | Edzard RomaneeBen Susanne Lehner | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，38，5： | 1 |
| 5 | Nano-structure blacks-a new carbonblack family designed to meet truck tire performance de-mands显示文摘 | Niedermeier Freund | 1999 | KGK1999，52，10： | 1 |
| 6 | Worstcase upper bounds for MAX-2- SAT with an application to MAXCUT 显示文摘 | GRAMM J HIRSCH E A NIEDERMEIER R | | Discrete Applied Mathematics0，2003，： | 1 |
| 7 | Detection of coast-line in SAR images using wavelet methods显示文摘 | Niedermeier A Romaneessen E Lehner S | | 0，，： | 1 |
| 8 | The effect of filler-filler and filler-elastomer interaction on rubber reinforcement 显示文摘 | Frohlich J Niedermeier W Luginsland H-D | 2005 | Composites Part A: Applied Science and Manufacturing2005，36，4： | 1 |
| 9 | Reinforcement mechanism in the rubbermatrix by active fillers显示文摘 | W Niedermeier | 2002 | KGK2002，55，78： | 1 |
| 10 | CD4 T cells control the differentiation of Grlt monocytes into fibrocytes显示文摘 | Niedermeier M Reich B Rodriguez Gomez M | 2009 | Proc Nat/Acad Sci USA2009，106，17： | 1 |
| 11 | Adjacent segment dis- ease显示文摘 | Virk SS Niedermeier S Yu E | 2014 | Orthopedics2014，37，8： | 1 |
| 12 | The effect of filler-filler and filler-elastomer interaction on rubber rein- foreement显示文摘 | Fr6hlich J Niedermeier W Luginsland H D | 2005 | Composites Part A2005，36，4： | 1 |
| 13 | Wounding enhances expression of AtSUC3,a sucrose transporter from Arabidopsis sieve elements and sink tissues显示文摘 | Meyer S Lauterbach C Niedermeier M | 2004 | Plant Physiology2004，134，2： | 1 |
| 14 | An ABA -responsive element in the AtSUC1 promoter is in- volved in the regulation of AtSUC1 expression显示文摘 | Hoth S Niedermeier M Feuerstein A | 2010 | Plan- ta2010，232，： | 1 |
| 15 | Monitoring Big Riv- er Estuaries Using SAR Images 显示文摘 | NIEDERMEIER A LEHNERS SANDER J | 2001 | Geoscience and Remote Sensing Symposium2001，，4： | 1 |
| 16 | Systemic contact dermatitis elicited by oral intake of Balsam of Peru 显示文摘 | Pfutzner W Thomas P Niedermeier A | 2003 | Acta Derm Venereol2003，83，4： | 1 |
| 17 | Direct current electrical fields induce apoptosis in oral mucosa cancer cells by NADPH oxidase-derived reactive oxygen species 显示文摘 | Wartenberg M Wirtz N Grob A Niedermeier W Hescheler J Peters SC | 2008 | Bioelectromagnetics2008，29，1： | 1 |
| 18 | Overexpression of the CXCR5 chemokine receptor,and its ligand,CXCL13 in Bcell chronic lymphocytic leukemia显示文摘 | Burkle A Niedermeier M Schmitt-Graff A | 2007 | Blood2007，110，9： | 1 |
| 19 | Adjacent segment dis- ease显示文摘 | Virk SS Niedermeier S Yu E | 2014 | Orthopedics2014，37，8： | 1 |
| 20 | ntroducing a novel Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) in pemphigus显示文摘 | Pftitze M Niedermeier A Hertl M | 2007 | European Journal of Dermatology2007，17，1： | 1 |
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