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| 1 | Dimensions of hepatocellular carcinoma phenotypic diversity显示文摘Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying 'clinically-friendly' molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the remaining challenges to translate our cognitive corpus into patient diagnosis and allocation to therapeutic options. | Romain Désert Natalia Nieto Orlando Musso | 2018 | World Journal of Gastroenterology2018，24，40： | 3 |
| 2 | On a Shallow Water Model for the Simulation of Turbidity Currents显示文摘We present a model for hyperpycnal plumes or turbidity currents that takes into account the interaction between the turbidity current and the bottom,considering deposition and erosion effects as well as solid transport of particles at the bed load due to the current.Water entrainment from the ambient water in which the turbidity current plunges is also considered.Motion of ambient water is neglected and the rigid lid assumption is considered.The model is obtained as a depth-average system of equations under the shallow water hypothesis describing the balance of fluid mass,sediment mass and mean flow.The character of the system is analyzed and numerical simulations are carried out using finite volume schemes and path-conservative Roe schemes. | T.Morales de Luna M.J.Castro Dıaz C.Pares Madronal E.D.Fernandez Nieto | 2009 | Communications in Computational Physics2009，6，9： | 2 |
| 3 | Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study显示文摘 | Nieto F J Young TB Lind BK Shahar E Samet JM Redline S D’ Agostino RB Newman AB Lebowitz MD Picketing TG | 2000 | JAMA2000，283，： | 1 |
| 4 | Mass wasting triggered by the 5 March 1987 Ecuador earthquakes显示文摘 | Schuster R L Nieto A S O'Rourke T D | 1996 | Engineering Geology1996，42，1： | 1 |
| 5 | A generalization of the monotone method for second order periodic boundary value problem with impulses at fixed points显示文摘 | Cabada A Nieto J J Franco D | 2000 | Dynam Contin Discrete Impuls Sys2000，7，2： | 1 |
| 6 | Influence of sex and terminal sire line on performance and carcass and meat quality of Iberian pigs reared under intensive production systems 显示文摘 | Serrano M P Valencia D G Nieto M | 2008 | Meat Science2008，，78： | 1 |
| 7 | Non-linear Analysis of Cable Networks by FEM and Experimental Validation 显示文摘 | DEL COZ DIAZ J J GARCIA NIETO P J CASTRO FRESNO D | 2009 | International Journal of Computer Mathematics2009，86，2： | 1 |
| 8 | An adaptive link assignment algorithm for dynamically changing topologies 显示文摘 | Noakes M D Cain J B Nieto J W | 1993 | IEEE Transactions on Communication1993，41，5： | 1 |
| 9 | Knee joint torques: a comparison between women and men during barefoot walking 显示文摘 | Kerrigan D C Riley P O Nieto T J | 2000 | Arch Phys Med Rehabil2000，81，： | 1 |
| 10 | Variational approach to impulsive differential equations显示文摘 | Nieto J J O'Regan D | | 0，，： | 1 |
| 11 | Serum Uric Acid and Risk of Coronary Heart Disease显示文摘 | Joseph T Moriarity Aaron R Folsom Carlos Iribarren F.Javier Nieto Wayne D Rosamond | 2000 | Annals of Epidemiology2000，，3： | 1 |
| 12 | Uric acid and serum antioxidantcapacity:a reaction to athemsclerosis 显示文摘 | Nieto F J Iribarren C Gross M D | 2000 | Atherosclemsis2000，148，1： | 1 |
| 13 | Sludge minimisation technologies显示文摘 | PEREZ-ELVIRA S I NIETO D P FDZ-POLANCO F | 2006 | Reviews in Environmental Science and Biotechnology2006，5，4： | 1 |
| 14 | Linear first-order fuzzy differential equation显示文摘 | Nieto J J Rodriguez-Lopez R Franco D | 2006 | International Journal of Uncertainty Fuzziness Knowledge-Based Systems2006，14，： | 1 |
| 15 | Structural changes in apple tissue during glucose and sucrose osmotic dehydration: shrinkage, porosity, density and microscopic features 显示文摘 | Nieto A B Salvatori D M | 2004 | Journal of Food Engineering2004，61，： | 1 |
| 16 | Correlation of Snail expression with histological grade and lymph node status in breast carcinomas显示文摘 | Blanco MJ Moreno-Bueno G Sarrio D Locascio A Cano A Palacios J Nieto MA | | 0，，20： | 1 |
| 17 | Association of usual sleep duration with hypertension: the sleep heart health study显示文摘 | Gottlieb D J Redline S Nieto FJ | 2006 | Sleep2006，29，8： | 1 |
| 18 | first-order differential equations显示文摘 | Chen Y Q Nieto J J O’Regan D Anti-periodic solutions for fully nonlinear | 2007 | Math Computer Modelling2007，46，911： | 1 |
| 19 | Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts显示文摘 | WILKINSON D G NIETO M A | 1993 | Methods Enzymol1993，225，1： | 1 |
| 20 | Dynamics of Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2) DNA loads in serum of healthy and postweaning multisystemic wasting syndrome (PMWS) affected pigs显示文摘 | Nieto D Aramouni M Grau-Roma L | 2011 | Veterinary Microbiology2011，152，34： | 1 |
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