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您的检索式：作者名="Nigel C.BENNETT"
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| 1 | Teasing apart socially-induced infertility in non-reproductive female Damaraland mole-rats, Fukomys damarensis (Rodentia:Bathyergidae)显示文摘The Damaraland mole-rat is a subterranean mammal exhibiting extreme reproductive skew with a single reproductive female in each colony responsible for procreation.Non-reproductive female colony members are physiologically suppressed while in the colony,exhibiting reduced concentrations of plasma luteinizing hormone(LH)and a decreased response of the pituitary,as measured by the release of bioactive LH,to an exogenous dose of gonadotrophin releasing hormone(GnRH).Removal of the reproductive female from the colony results in an elevation of LH and an enhanced response of the pituitary to a GnRH challenge in non-reproductive females comparable to reproductive females,implying control of reproduction in these individuals by the reproductive female.The Damaraland mole-rat is an ideal model for investigating the physiological and behavioral mechanisms that regulate the hypothalamo-pituitary-gonadal axis.In contrast,we know less about the control of reproduction at the level of the hypothalamus.The immunohistochemistry of the GnRH system of both reproductive and non-reproductive female Damaraland mole-rats has revealed no significant differences with respect to morphology,distribution or numbers of immunoreactive GnRH perikarya.We examined whether the endogenous opioid peptide beta-endorphin was responsible for the inhibition of the release of the GnRH from the neurons indirectly by measuring LH concentrations in these non-reproductive females following single,hourly and 8 hourly injections of the opioid antagonist naloxone.The results imply that the endogenous opioid peptide,beta-endorphin,is not responsible for the inhibition of GnRH release from the perikarya in non-reproductive females.Preliminary data examining the circulating levels of cortisol also do not support a role for circulating glucocorticoids.The possible role of kisspeptin is discussed. | Nigel C.BENNETT | 2011 | Integrative Zoology2011，6，4： | 0 |
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