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| 1 | Retroperitoneal fibrosis associated with immunoglobulin G4-related disease显示文摘Retroperitoneal fibrosis is a rare disease characterized by the development of inflammation and fibrosis in the soft tissues of the retroperitoneum and other abdominal organs.Retroperitoneal fibrosis can be of 2 types:idiopathic and secondary.The recently advocated concept and diagnostic criteria of immunoglobulin G4(IgG4)-related disease,derived from research on autoimmune pancreatitis(AIP),has led to widespread recognition of retroperitoneal fibrosis as a condition caused by IgG4-related disease.We now know that previously diagnosed idiopathic retroperitoneal fibrosis includes IgG4-related disease;however,the actual prevalence is unclear.Conversely,some reports on AIP suggest that retroperitoneal fibrosis is concurrently found in about 10% of IgG4-related disease.Because retroperitoneal fibrosis has no specific symptoms,diagnosis is primarily based on diagnostic imaging(computed tomography and magnetic resonance imaging),which is also useful in evaluating the effect of therapy.Idiopathic retroperitoneal fibrosis can occur at different times with other lesions of IgG4-related disease including AIP.Thus,the IgG4 assay is recommended to diagnose idiopathic retroperitoneal fibrosis.High serum IgG4 levels should be treated and monitored as a symptom of IgG4-related disease.The first line of treatment for retroperitoneal fibrosis is steroid therapy regardless of its cause.For patients with concurrent AIP,i.e.,IgG4-related retroperitoneal fibrosis,the starting dose of steroid is usually 30-40 mg/d.The response to steroid therapy is generally favorable.In most cases,the pancreatic lesion and retroperitoneal fibrosis improve after the initial treatment.However,the epidemiology,treatment for recurring retroperitoneal fibrosis,and long-term prognosis are still largely unknown.Further analysis of such cases and research are necessary. | Nao Fujimori Tetsuhide Ito Hisato Igarashi Takamasa Oono Taichi Nakamura Yusuke Niina Masayuki Hijioka Lingaku Lee Masahiko Uchida Ryoichi Takayanagi | 2013 | World Journal of Gastroenterology2013，19，1： | 14 |
| 2 | Promising biological therapies for ulcerative colitis: A review of the literature显示文摘Ulcerative colitis(UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants(including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor(TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab(anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab(another anti-TNF-α agent), tofacitinib(a Janus kinase inhibitor), and vedolizumab and etrolizumab(integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC. | Hirotada Akiho Azusa Yokoyama Shuichi Abe Yuichi Nakazono Masatoshi Murakami Yoshihiro Otsuka Kyoko Fukawa Mitsuru Esaki Yusuke Niina Haruei Ogino | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 3 | Endoscopic approach through the minor papilla for the management of pancreatic diseases显示文摘AIM:To clarify the efficacy and safety of an endoscopic approach through the minor papilla for the management of pancreatic diseases.METHODS:This study included 44 endoscopic retrograde cholangiopancreatography(ERCP) procedures performed in 34 patients using a minor papilla approach between April 2007 and March 2012.We retrospectively evaluated the clinical profiles of the patients,the endoscopic interventions,short-term outcomes,and complications.RESULTS:Of 44 ERCPs,26 were diagnostic ERCP,and 18 were therapeutic ERCP.The most common cause of difficult access to the main pancreatic duct through the major papilla was pancreas divisum followed by distortion of Wirsung's duct.The overall success rate of minor papilla cannulation was 80%(35/44),which was significantly improved by wire-guided cannulation(P = 0.04).Endoscopic minor papillotomy(EMP) was performed in 17 of 34 patients(50%) using a needle-knife(13/17) or a pull-type papillotome(4/17).EMP with pancreatic stent placement,which was the main therapeutic option for patients with chronic pancreatitis,recurrent acute pancreatitis,and pancreatic pseudocyst,resulted in short-term clinical improvement in 83% of patients.Mild post-ERCP pancreatitis occurred as an early complication in 2 cases(4.5%).CONCLUSION:The endoscopic minor papilla approach is technically feasible,safe,and effective when the procedure is performed in a high-volume referral center by experienced endoscopists. | Nao Fujimori Hisato Igarashi Akira Asou Ken Kawabe Lingaku Lee Takamasa Oono Taichi Nakamura Yusuke Niina Masayuki Hijioka Masahiko Uchida Kazuhiro Kotoh Kazuhiko Nakamura Tetsuhide Ito Ryoichi Takayanagi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 6 |
| 4 | Landfill leachate treatment with sequencing batch reactor and membrane bioreactor显示文摘 | Niina Laitinen Antero Luonsi Jari Vilen | | 0，，1： | 1 |
| 5 | EDDS-enhanced electrokinetic remediation of heavy metal-contaminated clay soils under neutral p H conditions显示文摘 | SUZUKI T NIINAE M KOGA T | 2014 | Colloids and Surfaces a-Physicochemical and Engineering Aspects2014，440，： | 1 |
| 6 | Management o{ pain in chronic pancreatitis with home elemental diet ingestion显示文摘 | Ito T Igarashi H Niina Y etal | 2010 | JOP2010，11，6： | 1 |
| 7 | Community stakeholders' knowledge in landscape assessments-Mapping indicators for landscape services显示文摘 | NORA FAGERHOLMA NIINA KYHKOA FESTO NDUMBAROB | 2012 | Ecological Indicators2012，18，： | 1 |
| 8 | Past,Present and Future of Mobile Payments Research:A literature Review显示文摘 | Tomi Dahlberg Niina Mallat Jan Ondms Agnieszka Zmijewska | 2008 | Hecteonic Commerce Resrarch and applications2008，7，2： | 1 |
| 9 | Development and validation for high selective quantitative determination of mefformin in human plasma by cation exchanging with normalphase LC/MS/MS 显示文摘 | Nozomu Koseki Hiroto Kawashita Miyuki Niina | 2005 | J Pharm Biomed Anal2005，36，： | 1 |
| 10 | Effect of-linolenic acid rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects显示文摘 | Henna M Karvonen Antti Aro Niina S Tapola | 2002 | Metabolism2002，51，10： | 1 |
| 11 | Engineering properties of improved soil obtained by stabilizing alluvial clay from various regions with cement slurry显示文摘 | Niina A S Saitoh R Babasaki T | 1981 | Takenaka Technical Research Report1981，25，： | 1 |
| 12 | Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection显示文摘 | Akinori Nakashima Christoph Saxer Miyuki Niina Naoki Masuda Kazuhide Iwasaki Kotaro Furukawa | 2001 | Journal of Chromatography B: Biomedical Sciences and Applications2001，760，： | 1 |
| 13 | Adiponectin-induced antiangiogenesis and antitumor activity involve caspasemediated endothelial cell apoptosis显示文摘 | Ebba B Niina V Renhai C | 2004 | PNAS2004，104，8： | 1 |
| 14 | Ortho-azo substituted phenylboronic acids for colorimetric sugar sensors显示文摘 | EGAWA Y Y GOTOH R NIINA S | 2007 | Bioorg Med Chem Lett2007，17，： | 1 |
| 15 | Exploring Merchant Adoption of Mobile PaymentSystems:A n Empi r ica l St udy显示文摘 | Mallat Niina Tuunainen Virpi Kristiina | 2007 | The Jou r na l ofStrategic Information Systems2007，16，4： | 1 |
| 16 | Past, present and future of mobile payments research: A literature review显示文摘 | Tomi Dahlberg Niina Mallat Jan Ondrus Agnieszka Zmijewska | 2007 | Electronic Commerce Research and Applications2007，，2： | 1 |
| 17 | Argument interpretations in the ditransitive construction 显示文摘 | Zhang Niina Ning | 1998 | Nordic Journal of Linguistics1998，，21： | 1 |
| 18 | Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection显示文摘 | NAKASHIMA A SAXER C NIINA M | 2001 | J Chromatogr B Biomed Sci Appl2001，760，1： | 1 |
| 19 | Ca^2+-dependent cosecretion of adrenomedullin and catechol amines mediated by nicotinic receptors in bovine cultured adrenalmedullary cells 显示文摘 | Katoh F Niina H Kitamura K | 1994 | FEBS Lett1994，348，： | 1 |
| 20 | 查看详情显示文摘 | Suzuki T Oyama Y Moribe M Niinae M | | 0，，： | 1 |
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