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| 1 | Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B显示文摘瞄准:由严峻的 TH1 和 TH2 承诺和规章的 T 房间学习 HBV 特定的 CD4+ T 房间的 hyporesponsiveness 的机制。方法:有长期的肝炎 B 的九个病人被注册。外部血单音的原子房间与 HBcAg 或 HBsAg 被刺激评估他们的潜力承诺 TH1 和 TH2 区别。规章的 T 房间的 HBcAg 特定的活动被与抗体染色到 CD4, CD25, CTLA-4 和 interleukin-10 评估。规章的 T 房间的角色被治疗进一步与 anti-interleukin-10 抗体和 CD4+CD25+ 房间的弄空估计。结果:为 T 赌注, IL-12R beta2 和 IL-4 的 mRNAs 的水平比在有 HBcAg 刺激的健康题目在病人是显著地更低的。尽管 CD4+CD25highCTLA-4+ T 房间的人口不在病人和健康题目之间是不同的, IL-10 secreting 房间响应 HBcAg 在病人在 CD4+ 房间和 CD4+CD25+ 房间被发现,并且他们没在与 HBsAg 被刺激的房间被发现。anti-IL-10 抗体的增加与控制抗体相比恢复了 HBcAg 特定的 TH1 抗体的数量(P <
0.01, 0.34%+/-0.12% 对 0.15%+/-0.04%) 。当时, CD4+CD25+ T 房间的删除增加了 HBcAg 特定的 TH1 抗体的数量与淋巴细胞相比使用规章的 T 房间重新组成(P <
0.01, 0.03%+/-0.02% 对 0.18%+/-0.05%) 。结论:结果显示到 HBcAg 的 T 房间 hyporesponsiveness 的机制响应 HBsAg 与承诺 TH2 的房间的增加相对照包括导致 HBcAg 的规章的 T 房间的激活。 | Yasuteru Kondo Koju Kobayashi Yoshiyuki Ueno Masaaki Shiina Hirofumi Niitsuma Noriatsu Kanno Tomoo Kobayashi Tooru Shimosegawa | 2006 | World Journal of Gastroenterology2006，12，27： | 16 |
| 2 | Effect of Graft Yield on the Thermo-Responsive Permeability Through Porous Membranes with Plasma-Grafted Poly(N-isopropylacrylamide)Gates显示文摘The effect of graft yield on both the thermo-responsive hydraulic permeability and the thermo-respousive diffusional permeability through porous membranes with plasma-grafted poly(N-isopropylacrylamide) (PNIPAM)gates was investigated. Both thermo-respousive flat membranes and core-shell microcapsule membranes with a wide range of graft yield of PNIPAM were prepared using a plasma-graft pore-filling polymerization method. The grafted PNIPAM was formed homogeneously throughout the entire thickness of both the fiat polyethylene membranes andthe microcapsule polyamide membranes. Both the hydraulic permeability and the diffusional permeability were heavily dependent on the PNIPAM graft yield. With increasing the graft yield, the hydraulic permeability (water flux) decreases rapidly at 25℃ because of the decrease of the pore size; however, the water flux at 40℃ increases firstly to a peak because of the increase of hydrophobicity of the pore surface, and then decreases and finally tends to zero because of the pore size becoming smaller and smaller. For the diffusional permeability, the temperature shows different effects on the diffusional permeability coefficients of solutes across the membranes. When the graft yield was low, the diffusional coefficient of solute across the membrane was higher at temperature above the lower critical solution temperature (LCST) than that below the LCST; however, when the graft yield was high, the diffusional coefficient was lower at temperature above the LCST than that below the LCST. It is very important to choose or design a proper graft yield of PNIPAM for obtaining a desired thermo-respousive 'on/off' hydraulic or ditfusional permeability. | 褚良银 朱家骅 陈文梅 NIITSUMA Takuya YAMAGUCHI Takeo NAKAO Shin-ichi | 2003 | Chinese Journal of Chemical Engineering2003，11，3： | 6 |
| 3 | Antimi- crobial susceptibility of Pseudomonas aeruginosa isolated in Fukushima prefecture 显示文摘 | NIITSUMA K SAITOH M KOJIMABARA M | 2001 | JPN J Antibiot2001，54，2： | 1 |
| 4 | Antimicrobial suscieptibility of Pseudomonas aeruginosa isolated in Fukushim a Prefecture 显示文摘 | Niitsuma K Saitoh M Kojimabara M | 2001 | Jpn J Antibiot2001，54，2： | 1 |
| 5 | Antimicrobial suscieptibility of Pseudomonas aeruginosa isolated in Fukushima Prefecture显示文摘 | Niitsuma K Saitoh M Kojimabara M | | 0，，02： | 1 |
| 6 | Cathodoluminescence Characterization of ZnO Nanotubes Grown by MOCVD on Sapphire Substrate 显示文摘 | Yuan X L Zhang B P Niitsuma J | 2006 | Materials Science in Semiconductor Processing2006，9，： | 1 |
| 7 | Experimental study of decubitus ulcer formation in the rabbit ear lobe显示文摘 | Niitsuma J Yano H Togawa T | 2003 | J Rehabil Res Dev2003，40，1： | 1 |
| 8 | Microseismicity and permeability enhancement of hydrogeologic structures during massive fluid injections into granite at 3 km depth at the Soultz HDR site显示文摘 | Evans K F Moriya H Niitsuma H et aI | 2005 | GeophysicalJournal International2005，160，38： | 1 |
| 9 | Detailed Fracture System of the Soultz-sous-Forêts HDR Field Evaluated Using Microseismic Multiplet Analysis显示文摘 | H. Moriya K. Nakazato H. Niitsuma R. Baria | 2002 | Pure and Applied Geophysics (-)2002，，1： | 1 |
| 10 | Experimental study of deeubitus ulcer formation in the rabbit ear lobe显示文摘 | Niitsuma J Yano H Togawa T | 2003 | J Rehabil Res Dev2003，40，1： | 1 |
| 11 | Interferon-gamma inhibits the growth of human bronchial epithelial cells independently of transforming growth factor-beta-1 and nitric oxide(NO)显示文摘 | Niitsuma T Hayshi T | 1998 | Biochem Biop-hys Res Commun1998，244，3： | 1 |
| 12 | Stress estimated using microseismic clusters and its relationship to the fracture system of the Hijiori hot dry rock reservoir显示文摘 | TEZUKA K NIITSUMA H | 2000 | Engineering Geology2000，56，12： | 1 |
| 13 | Precise detection of a P-wave in low S/N signal by using Time-Frequency representations of a triaxial hodogram显示文摘 | Hirokazu Moriya Hiroaki Niitsuma | 1996 | Geophysics1996，61，5： | 1 |
| 14 | Interferon gamma inhibits the growth of human bronchial epithelial cells independently of transforming growth factor beta-1 and nitric oxide (NO)显示文摘 | Kobayashi M Niitsuma T Hayshi T | 1998 | Biochem Biop-hys Res Commun1998，244，3： | 1 |
| 15 | Experimental study of decubitus ulcer formation in the rabbit ear lobe显示文摘 | Niitsuma J Yano H Togawa T | | 0，，01： | 1 |
| 16 | Sonic hedgehog isa critical mediator of erythropoietin -induced cardiacprotection in mice显示文摘 | Ueda K Takano H Niitsuma Y | 2010 | J Clin Invest2010，120，6： | 1 |
| 17 | The high incidence of the emergence of entecavir - resistant mutants among patients infected with lamivudinc - resistant hepatitis B virus 显示文摘 | Nagasaki F Niitsuma H Ueno Y | 2007 | Tohoku J Exp Med2007，213，2： | 1 |
| 18 | Antinierobial Suscepotibility of Pseudomonas aerufinosa isolated in Fukushina Prefecture显示文摘 | Niitsuma K Saitoh M Kojmabara M | 2003 | Pn Antibiotic2003，54，2： | 1 |
| 19 | Cathodoluminescence characterization of ZnO nanotubes grown by MOCVD on sap- phire substrate 显示文摘 | Yuan X L Zhang B P Niitsuma J | 2006 | Mater Sci Semicond Process2006，9，123： | 1 |
| 20 | The high incidence of the emergence of entecavir-resistant mutants among patients infected with lamivudine-resistant hepatitis B virus显示文摘 | Nagasaki F Niitsuma H Ueno Y | 2007 | Tohoku J Exp Med2007，213，1： | 1 |
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